Metabolic syndrome and the benefit of a physical activity intervention on lower-extremity function: Results from a randomized clinical trial
In older adults, increases in physical activity may prevent decline in lower-extremity function, but whether the benefit differs according to metabolic syndrome (MetS) status is uncertain. We aim to investigate whether structured physical activity is associated with less decline in lower-extremity f...
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| Veröffentlicht in: | Experimental gerontology 2021-07, Vol.150, p.111343-111343, Article 111343 |
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| creator | Botoseneanu, Anda Chen, Haiying Ambrosius, Walter T. Allore, Heather G. Anton, Stephen Folta, Sara C. King, Abby C. Nicklas, Barbara J. Spring, Bonnie Strotmeyer, Elsa S. Gill, Thomas M. |
| description | In older adults, increases in physical activity may prevent decline in lower-extremity function, but whether the benefit differs according to metabolic syndrome (MetS) status is uncertain. We aim to investigate whether structured physical activity is associated with less decline in lower-extremity function among older adults with versus without MetS.
We used data from the multicenter Lifestyle Interventions and Independence for Elders (LIFE) study to analyze 1535 sedentary functionally-vulnerable women and men, aged 70 to 89 years old, assessed every 6 months (February 2010–December 2013) for an average of 2.7 years. Participants were randomized to a structured, moderate-intensity physical activity intervention (PA; n = 766) or health education program (HE; n = 769). MetS was defined according to the 2009 multi-agency harmonized criteria. Lower-extremity function was assessed by 400-m walking speed and the Short Physical Performance Battery (SPPB) score.
763 (49.7%) participants met criteria for MetS at baseline. Relative to HE, PA was associated with faster 400-m walking speed among participants with MetS (P |
| doi_str_mv | 10.1016/j.exger.2021.111343 |
| format | Article |
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We used data from the multicenter Lifestyle Interventions and Independence for Elders (LIFE) study to analyze 1535 sedentary functionally-vulnerable women and men, aged 70 to 89 years old, assessed every 6 months (February 2010–December 2013) for an average of 2.7 years. Participants were randomized to a structured, moderate-intensity physical activity intervention (PA; n = 766) or health education program (HE; n = 769). MetS was defined according to the 2009 multi-agency harmonized criteria. Lower-extremity function was assessed by 400-m walking speed and the Short Physical Performance Battery (SPPB) score.
763 (49.7%) participants met criteria for MetS at baseline. Relative to HE, PA was associated with faster 400-m walking speed among participants with MetS (P < 0.001) but not among those without MetS (P = 0.91), although the test for statistical interaction was marginally non-significant (P = 0.07). In contrast, no benefit of PA versus HE was observed on the SPPB score in either MetS subgroup.
Among older adults at high risk for mobility disability, moderate-intensity physical activity conveys significant benefits in 400-m walking speed but not SPPB in those with, but not without, MetS. The LIFE physical activity program may be an effective strategy for maintaining or improving walking speed among vulnerable older adults with MetS.
clinicaltrials.gov Identifier: NCT01072500
•50% of older adults at high-risk for mobility disability met the criteria for metabolic syndrome (MetS)•Physical activity (PA) intervention improved 400-meter walking speed in vulnerable older adults with MetS but not in those without MetS•PA did not improve SPPB scores in older adults with or without MetS•Exercise may be an effective strategy for maintaining mobility among older adults with MetS•Other strategies need to be identified for maintaining mobility among metabolically-healthy older adults</description><identifier>ISSN: 0531-5565</identifier><identifier>EISSN: 1873-6815</identifier><identifier>DOI: 10.1016/j.exger.2021.111343</identifier><identifier>PMID: 33848565</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Exercise ; Exercise Therapy ; Female ; Humans ; Lower Extremity ; Male ; Metabolic syndrome ; Metabolic Syndrome - therapy ; Mobility Limitation ; Physical activity intervention ; Randomized clinical trial ; Sedentary Behavior ; Short physical performance battery ; Walking speed</subject><ispartof>Experimental gerontology, 2021-07, Vol.150, p.111343-111343, Article 111343</ispartof><rights>2021 Elsevier Inc.</rights><rights>Copyright © 2021 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-478b3a4fe70dc8f84f2d6b48ea38f8507572e5fb60de790cbfb6657b281a2d123</citedby><cites>FETCH-LOGICAL-c459t-478b3a4fe70dc8f84f2d6b48ea38f8507572e5fb60de790cbfb6657b281a2d123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0531556521001182$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33848565$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Botoseneanu, Anda</creatorcontrib><creatorcontrib>Chen, Haiying</creatorcontrib><creatorcontrib>Ambrosius, Walter T.</creatorcontrib><creatorcontrib>Allore, Heather G.</creatorcontrib><creatorcontrib>Anton, Stephen</creatorcontrib><creatorcontrib>Folta, Sara C.</creatorcontrib><creatorcontrib>King, Abby C.</creatorcontrib><creatorcontrib>Nicklas, Barbara J.</creatorcontrib><creatorcontrib>Spring, Bonnie</creatorcontrib><creatorcontrib>Strotmeyer, Elsa S.</creatorcontrib><creatorcontrib>Gill, Thomas M.</creatorcontrib><title>Metabolic syndrome and the benefit of a physical activity intervention on lower-extremity function: Results from a randomized clinical trial</title><title>Experimental gerontology</title><addtitle>Exp Gerontol</addtitle><description>In older adults, increases in physical activity may prevent decline in lower-extremity function, but whether the benefit differs according to metabolic syndrome (MetS) status is uncertain. We aim to investigate whether structured physical activity is associated with less decline in lower-extremity function among older adults with versus without MetS.
We used data from the multicenter Lifestyle Interventions and Independence for Elders (LIFE) study to analyze 1535 sedentary functionally-vulnerable women and men, aged 70 to 89 years old, assessed every 6 months (February 2010–December 2013) for an average of 2.7 years. Participants were randomized to a structured, moderate-intensity physical activity intervention (PA; n = 766) or health education program (HE; n = 769). MetS was defined according to the 2009 multi-agency harmonized criteria. Lower-extremity function was assessed by 400-m walking speed and the Short Physical Performance Battery (SPPB) score.
763 (49.7%) participants met criteria for MetS at baseline. Relative to HE, PA was associated with faster 400-m walking speed among participants with MetS (P < 0.001) but not among those without MetS (P = 0.91), although the test for statistical interaction was marginally non-significant (P = 0.07). In contrast, no benefit of PA versus HE was observed on the SPPB score in either MetS subgroup.
Among older adults at high risk for mobility disability, moderate-intensity physical activity conveys significant benefits in 400-m walking speed but not SPPB in those with, but not without, MetS. The LIFE physical activity program may be an effective strategy for maintaining or improving walking speed among vulnerable older adults with MetS.
clinicaltrials.gov Identifier: NCT01072500
•50% of older adults at high-risk for mobility disability met the criteria for metabolic syndrome (MetS)•Physical activity (PA) intervention improved 400-meter walking speed in vulnerable older adults with MetS but not in those without MetS•PA did not improve SPPB scores in older adults with or without MetS•Exercise may be an effective strategy for maintaining mobility among older adults with MetS•Other strategies need to be identified for maintaining mobility among metabolically-healthy older adults</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Exercise</subject><subject>Exercise Therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Lower Extremity</subject><subject>Male</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - therapy</subject><subject>Mobility Limitation</subject><subject>Physical activity intervention</subject><subject>Randomized clinical trial</subject><subject>Sedentary Behavior</subject><subject>Short physical performance battery</subject><subject>Walking speed</subject><issn>0531-5565</issn><issn>1873-6815</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Ud1qFDEUDqLYbfUJBMmlN7PmZzKTCgpSrAoVQfQ6ZJKTbpZMsibZtesz-NBmu7XojRBITr6fk5wPoWeULCmhw8v1Em6uIS8ZYXRJKeU9f4AWVI68GyQVD9GCCE47IQZxgk5LWRNCBsbpY3TCuexlu1-gX5-g6ikFb3DZR5vTDFhHi-sK8AQRnK84OazxZrUv3uiAtal-5-se-1gh7yBWnyJuK6QfkDu4qRnmA-620RywV_gLlG2oBbtm36xya5Bm_xMsNsHHW9eavQ5P0COnQ4Gnd_sZ-nb57uvFh-7q8_uPF2-vOtOL89r1o5y47h2MxBrpZO-YHaZeguatEmQUIwPhpoFYGM-JmdpxEOPEJNXMUsbP0Juj72Y7zWBN-0PWQW2yn3Xeq6S9-heJfqWu005JLqVkohm8uDPI6fsWSlWzLwZC0BHStigmKBvbkAlpVH6kmpxKyeDu21CiDjmqtbrNUR1yVMccm-r53y-81_wJrhFeHwnQ5rTzTV6Mh2jA-gymKpv8fxv8BmlEtI8</recordid><startdate>20210715</startdate><enddate>20210715</enddate><creator>Botoseneanu, Anda</creator><creator>Chen, Haiying</creator><creator>Ambrosius, Walter T.</creator><creator>Allore, Heather G.</creator><creator>Anton, Stephen</creator><creator>Folta, Sara C.</creator><creator>King, Abby C.</creator><creator>Nicklas, Barbara J.</creator><creator>Spring, Bonnie</creator><creator>Strotmeyer, Elsa S.</creator><creator>Gill, Thomas M.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210715</creationdate><title>Metabolic syndrome and the benefit of a physical activity intervention on lower-extremity function: Results from a randomized clinical trial</title><author>Botoseneanu, Anda ; Chen, Haiying ; Ambrosius, Walter T. ; Allore, Heather G. ; Anton, Stephen ; Folta, Sara C. ; King, Abby C. ; Nicklas, Barbara J. ; Spring, Bonnie ; Strotmeyer, Elsa S. ; Gill, Thomas M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-478b3a4fe70dc8f84f2d6b48ea38f8507572e5fb60de790cbfb6657b281a2d123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Exercise</topic><topic>Exercise Therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Lower Extremity</topic><topic>Male</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - therapy</topic><topic>Mobility Limitation</topic><topic>Physical activity intervention</topic><topic>Randomized clinical trial</topic><topic>Sedentary Behavior</topic><topic>Short physical performance battery</topic><topic>Walking speed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Botoseneanu, Anda</creatorcontrib><creatorcontrib>Chen, Haiying</creatorcontrib><creatorcontrib>Ambrosius, Walter T.</creatorcontrib><creatorcontrib>Allore, Heather G.</creatorcontrib><creatorcontrib>Anton, Stephen</creatorcontrib><creatorcontrib>Folta, Sara C.</creatorcontrib><creatorcontrib>King, Abby C.</creatorcontrib><creatorcontrib>Nicklas, Barbara J.</creatorcontrib><creatorcontrib>Spring, Bonnie</creatorcontrib><creatorcontrib>Strotmeyer, Elsa S.</creatorcontrib><creatorcontrib>Gill, Thomas M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Experimental gerontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Botoseneanu, Anda</au><au>Chen, Haiying</au><au>Ambrosius, Walter T.</au><au>Allore, Heather G.</au><au>Anton, Stephen</au><au>Folta, Sara C.</au><au>King, Abby C.</au><au>Nicklas, Barbara J.</au><au>Spring, Bonnie</au><au>Strotmeyer, Elsa S.</au><au>Gill, Thomas M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic syndrome and the benefit of a physical activity intervention on lower-extremity function: Results from a randomized clinical trial</atitle><jtitle>Experimental gerontology</jtitle><addtitle>Exp Gerontol</addtitle><date>2021-07-15</date><risdate>2021</risdate><volume>150</volume><spage>111343</spage><epage>111343</epage><pages>111343-111343</pages><artnum>111343</artnum><issn>0531-5565</issn><eissn>1873-6815</eissn><abstract>In older adults, increases in physical activity may prevent decline in lower-extremity function, but whether the benefit differs according to metabolic syndrome (MetS) status is uncertain. We aim to investigate whether structured physical activity is associated with less decline in lower-extremity function among older adults with versus without MetS.
We used data from the multicenter Lifestyle Interventions and Independence for Elders (LIFE) study to analyze 1535 sedentary functionally-vulnerable women and men, aged 70 to 89 years old, assessed every 6 months (February 2010–December 2013) for an average of 2.7 years. Participants were randomized to a structured, moderate-intensity physical activity intervention (PA; n = 766) or health education program (HE; n = 769). MetS was defined according to the 2009 multi-agency harmonized criteria. Lower-extremity function was assessed by 400-m walking speed and the Short Physical Performance Battery (SPPB) score.
763 (49.7%) participants met criteria for MetS at baseline. Relative to HE, PA was associated with faster 400-m walking speed among participants with MetS (P < 0.001) but not among those without MetS (P = 0.91), although the test for statistical interaction was marginally non-significant (P = 0.07). In contrast, no benefit of PA versus HE was observed on the SPPB score in either MetS subgroup.
Among older adults at high risk for mobility disability, moderate-intensity physical activity conveys significant benefits in 400-m walking speed but not SPPB in those with, but not without, MetS. The LIFE physical activity program may be an effective strategy for maintaining or improving walking speed among vulnerable older adults with MetS.
clinicaltrials.gov Identifier: NCT01072500
•50% of older adults at high-risk for mobility disability met the criteria for metabolic syndrome (MetS)•Physical activity (PA) intervention improved 400-meter walking speed in vulnerable older adults with MetS but not in those without MetS•PA did not improve SPPB scores in older adults with or without MetS•Exercise may be an effective strategy for maintaining mobility among older adults with MetS•Other strategies need to be identified for maintaining mobility among metabolically-healthy older adults</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>33848565</pmid><doi>10.1016/j.exger.2021.111343</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aged Aged, 80 and over Exercise Exercise Therapy Female Humans Lower Extremity Male Metabolic syndrome Metabolic Syndrome - therapy Mobility Limitation Physical activity intervention Randomized clinical trial Sedentary Behavior Short physical performance battery Walking speed |
| title | Metabolic syndrome and the benefit of a physical activity intervention on lower-extremity function: Results from a randomized clinical trial |
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