Testosterone Plus Finasteride Prevents Bone Loss without Prostate Growth in a Rodent Spinal Cord Injury Model

We have reported that testosterone-enanthate (TE) prevents the musculoskeletal decline occurring acutely after spinal cord injury (SCI), but results in a near doubling of prostate mass. Our purpose was to test the hypothesis that administration of TE plus finasteride (FIN; type II 5α-reductase inhib...

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Veröffentlicht in:	Journal of neurotrauma 2017-11, Vol.34 (21), p.2972-2981
Hauptverfasser:	Yarrow, Joshua F, Phillips, Ean G, Conover, Christine F, Bassett, Taylor E, Chen, Cong, Teurlings, Tyler, Vasconez, Andrea, Alerte, Jonathan, Prock, Hannah, Jiron, Jessica M, Flores, Micah, Aguirre, J Ignacio, Borst, Stephen E, Ye, Fan
Format:	Artikel
Sprache:	eng
Schlagworte:	5-alpha Reductase Inhibitors - pharmacology Androgens Androgens - pharmacology Animals Bone growth Bone histomorphometry Bone loss Bone mass Bone Remodeling - drug effects Bone Resorption - etiology Bone Resorption - prevention & control Bone strength Bone turnover Cancellous bone Computed tomography Cortical bone Disease Models, Animal Femur Finasteride - pharmacology Hormone replacement therapy Male Muscle, Skeletal - drug effects Osteoporosis Prostate Prostate - drug effects Rats Rats, Sprague-Dawley Rodents Spinal cord injuries Spinal Cord Injuries - complications Steroid 5α-reductase Surgery Testosterone Testosterone - analogs & derivatives Testosterone - pharmacology Therapeutic applications
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