Pioglitazone mediates apoptosis in Caki cells via downregulating c‑FLIP (L) expression and reducing Bcl‑2 protein stability

Pioglitazone is an anti-diabetic agent used in the treatment of type 2 diabetes, which belongs to the thiazolidinediones (TZDs) group. TZDs target peroxisome proliferator-activated receptor γ (PPARγ), which functions as a transcription factor of the nuclear hormone receptor. Pioglitazone has antitum...

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Veröffentlicht in:	Oncology letters 2021-10, Vol.22 (4), Article 743
Hauptverfasser:	Jang, Ji Hoon, Lee, Tae-Jin, Sung, Eon-Gi, Song, In-Hwan, Kim, Joo-Young
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Apoptosis Flow cytometry Gastric cancer Kidney cancer Kinases Ligands Oncology Proteins Reactive oxygen species
Online-Zugang:	Volltext
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