SCD Inhibition Protects from α-Synuclein-Induced Neurotoxicity But Is Toxic to Early Neuron Cultures

Here, we report the independent discovery and validation of stearoyl-CoA desaturase (SCD) as a modulator of α-synuclein (αSyn)-induced pathology and toxicity in cell-based Parkinson’s disease (PD) models. We identified SCD as top altered gene from transcriptional profiling in primary neurons exogeno...

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Veröffentlicht in:	eNeuro 2021-07, Vol.8 (4), p.ENEURO.0166-21.2021
Hauptverfasser:	Nicholatos, Justin W., Groot, Joost, Dhokai, Shekhar, Tran, David, Hrdlicka, Lori, Carlile, Thomas M., Bennion, Melissa, Dalkilic-Liddle, Isin, Hirst, Warren D., Weihofen, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	New Research
Online-Zugang:	Volltext
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