Association Between Serum IL-6, IL-10, IL-12, and IL-23 Levels and Severity of Liver Cirrhosis
Liver cirrhosis contributes to high liver-related mortality globally. Systemic inflammation mediated by immune cells contributes to the progression of liver cirrhosis. Growing evidence shows that several pro- and anti-inflammatory cytokines might have an important role in liver cirrhosis. To evaluat...
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description | Liver cirrhosis contributes to high liver-related mortality globally. Systemic inflammation mediated by immune cells contributes to the progression of liver cirrhosis. Growing evidence shows that several pro- and anti-inflammatory cytokines might have an important role in liver cirrhosis.
To evaluate the association between serum IL-6, IL-10, IL-12, and IL-23 levels and severity of liver cirrhosis.
This observational study was carried out at the Department of Internal Medicine, Universitas Sumatera Utara, Indonesia from March 2018 to August 2019. The severity of liver cirrhosis was assessed by using the Child-Pugh score. IL-6, IL-10, IL-12, and IL-23 levels, hepatitis and renal function were measured in all study subjects. Independent t-test and Mann-Whitney tests were conducted to observe differences between groups.
A total of 78 liver cirrhosis patients were enrolled, mean age was 50.6±11.4. Median serum IL-6, IL-10, IL-12, and IL-23 levels were 24.5(2.6-46.4)pg/ml, 2.1(0.4-9.3)pg/ml, 3.5(1.4-20.8)pg/ml and 20.3(9.2-218)pg/ml, respectively. A higher IL-6 level was associated with more severe liver cirrhosis (p=0.001) and the presence of hepatic encephalopathy (p=0.018). Higher IL-23 level was found in patients with no hepatic encephalopathy (p=0.049). There was no association between serum cytokines levels and hepatitis viral infection status.
IL-6 is associated with the severity of liver cirrhosis. |
doi_str_mv | 10.5455/medarh.2021.75.199-203 |
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To evaluate the association between serum IL-6, IL-10, IL-12, and IL-23 levels and severity of liver cirrhosis.
This observational study was carried out at the Department of Internal Medicine, Universitas Sumatera Utara, Indonesia from March 2018 to August 2019. The severity of liver cirrhosis was assessed by using the Child-Pugh score. IL-6, IL-10, IL-12, and IL-23 levels, hepatitis and renal function were measured in all study subjects. Independent t-test and Mann-Whitney tests were conducted to observe differences between groups.
A total of 78 liver cirrhosis patients were enrolled, mean age was 50.6±11.4. Median serum IL-6, IL-10, IL-12, and IL-23 levels were 24.5(2.6-46.4)pg/ml, 2.1(0.4-9.3)pg/ml, 3.5(1.4-20.8)pg/ml and 20.3(9.2-218)pg/ml, respectively. A higher IL-6 level was associated with more severe liver cirrhosis (p=0.001) and the presence of hepatic encephalopathy (p=0.018). Higher IL-23 level was found in patients with no hepatic encephalopathy (p=0.049). There was no association between serum cytokines levels and hepatitis viral infection status.
IL-6 is associated with the severity of liver cirrhosis.</description><identifier>ISSN: 0350-199X</identifier><identifier>EISSN: 1986-5961</identifier><identifier>DOI: 10.5455/medarh.2021.75.199-203</identifier><identifier>PMID: 34483450</identifier><language>eng</language><publisher>Bosnia and Herzegovina: Academy of Medical Sciences of Bosnia and Herzegovina</publisher><subject>Adult ; Ascites ; Cytokines ; Hepatitis B ; Hepatitis C ; Humans ; Infections ; Inflammation ; Interleukin-10 ; Interleukin-12 ; Interleukin-23 ; Interleukin-6 ; Internal medicine ; Laboratories ; Liver Cirrhosis ; Liver diseases ; Middle Aged ; Observational studies ; Original Paper ; Statistical analysis ; Viral infections</subject><ispartof>Medical archives (Sarajevo, Bosnia and Herzegovina), 2021-06, Vol.75 (3), p.199-203</ispartof><rights>2021 Imelda Rey, Rustam Effendi-YS.</rights><rights>Copyright Academy of Medical Sciences of Bosnia and Herzegovina Jun 2021</rights><rights>2021 Imelda Rey, Rustam Effendi-YS 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3573-4a63d2bc30f68bad7c7b07e86f6ea1803e3cb01b69747032ecefca52e0e57a283</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385729/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385729/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34483450$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rey, Imelda</creatorcontrib><creatorcontrib>Effendi-Ys, Rustam</creatorcontrib><title>Association Between Serum IL-6, IL-10, IL-12, and IL-23 Levels and Severity of Liver Cirrhosis</title><title>Medical archives (Sarajevo, Bosnia and Herzegovina)</title><addtitle>Med Arch</addtitle><description>Liver cirrhosis contributes to high liver-related mortality globally. Systemic inflammation mediated by immune cells contributes to the progression of liver cirrhosis. Growing evidence shows that several pro- and anti-inflammatory cytokines might have an important role in liver cirrhosis.
To evaluate the association between serum IL-6, IL-10, IL-12, and IL-23 levels and severity of liver cirrhosis.
This observational study was carried out at the Department of Internal Medicine, Universitas Sumatera Utara, Indonesia from March 2018 to August 2019. The severity of liver cirrhosis was assessed by using the Child-Pugh score. IL-6, IL-10, IL-12, and IL-23 levels, hepatitis and renal function were measured in all study subjects. Independent t-test and Mann-Whitney tests were conducted to observe differences between groups.
A total of 78 liver cirrhosis patients were enrolled, mean age was 50.6±11.4. Median serum IL-6, IL-10, IL-12, and IL-23 levels were 24.5(2.6-46.4)pg/ml, 2.1(0.4-9.3)pg/ml, 3.5(1.4-20.8)pg/ml and 20.3(9.2-218)pg/ml, respectively. A higher IL-6 level was associated with more severe liver cirrhosis (p=0.001) and the presence of hepatic encephalopathy (p=0.018). Higher IL-23 level was found in patients with no hepatic encephalopathy (p=0.049). There was no association between serum cytokines levels and hepatitis viral infection status.
IL-6 is associated with the severity of liver cirrhosis.</description><subject>Adult</subject><subject>Ascites</subject><subject>Cytokines</subject><subject>Hepatitis B</subject><subject>Hepatitis C</subject><subject>Humans</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Interleukin-10</subject><subject>Interleukin-12</subject><subject>Interleukin-23</subject><subject>Interleukin-6</subject><subject>Internal medicine</subject><subject>Laboratories</subject><subject>Liver Cirrhosis</subject><subject>Liver diseases</subject><subject>Middle Aged</subject><subject>Observational studies</subject><subject>Original Paper</subject><subject>Statistical analysis</subject><subject>Viral infections</subject><issn>0350-199X</issn><issn>1986-5961</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpVUctOIzEQtNAiCCy_gEbaKxNs9_gxl5XYiJc0EoeAtCcsj9OzMUrGrD0J4u9xSEBw6S71o7pVRcgpo2NRCXG-xJmN8zGnnI2VGLO6LjmFPTJitZalqCX7QUYUBC1z6-8hOUrpiVJRK14fkEOoKg2VoCPyeJFScN4OPvTFHxxeEPtiinG1LG6bUp5tIqPbxM8K2882kEPR4BoX6b0wzTD64bUIXdH4jIuJj3Eekk8_yX5nFwlPdvmYPFxd3k9uyubu-nZy0ZQOhIKyshJmvHVAO6lbO1NOtVShlp1EyzQFBNdS1spaVYoCR4eds4IjRaEs13BMfm95n1dtlsZhP0S7MM_RL218NcF6873T-7n5F9ZGgxZZk0zwa0cQw_8VpsE8hVXs88-Ga1nLigGXeUpup1wMKUXsPi8waja-mK0vZuOLUcJk8TOGvHj69b_PtQ8j4A2jf4jz</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Rey, Imelda</creator><creator>Effendi-Ys, Rustam</creator><general>Academy of Medical Sciences of Bosnia and Herzegovina</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20210601</creationdate><title>Association Between Serum IL-6, IL-10, IL-12, and IL-23 Levels and Severity of Liver Cirrhosis</title><author>Rey, Imelda ; Effendi-Ys, Rustam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3573-4a63d2bc30f68bad7c7b07e86f6ea1803e3cb01b69747032ecefca52e0e57a283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Ascites</topic><topic>Cytokines</topic><topic>Hepatitis B</topic><topic>Hepatitis C</topic><topic>Humans</topic><topic>Infections</topic><topic>Inflammation</topic><topic>Interleukin-10</topic><topic>Interleukin-12</topic><topic>Interleukin-23</topic><topic>Interleukin-6</topic><topic>Internal medicine</topic><topic>Laboratories</topic><topic>Liver Cirrhosis</topic><topic>Liver diseases</topic><topic>Middle Aged</topic><topic>Observational studies</topic><topic>Original Paper</topic><topic>Statistical analysis</topic><topic>Viral infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rey, Imelda</creatorcontrib><creatorcontrib>Effendi-Ys, Rustam</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>East Europe, Central Europe Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medical archives (Sarajevo, Bosnia and Herzegovina)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rey, Imelda</au><au>Effendi-Ys, Rustam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association Between Serum IL-6, IL-10, IL-12, and IL-23 Levels and Severity of Liver Cirrhosis</atitle><jtitle>Medical archives (Sarajevo, Bosnia and Herzegovina)</jtitle><addtitle>Med Arch</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>75</volume><issue>3</issue><spage>199</spage><epage>203</epage><pages>199-203</pages><issn>0350-199X</issn><eissn>1986-5961</eissn><abstract>Liver cirrhosis contributes to high liver-related mortality globally. Systemic inflammation mediated by immune cells contributes to the progression of liver cirrhosis. Growing evidence shows that several pro- and anti-inflammatory cytokines might have an important role in liver cirrhosis.
To evaluate the association between serum IL-6, IL-10, IL-12, and IL-23 levels and severity of liver cirrhosis.
This observational study was carried out at the Department of Internal Medicine, Universitas Sumatera Utara, Indonesia from March 2018 to August 2019. The severity of liver cirrhosis was assessed by using the Child-Pugh score. IL-6, IL-10, IL-12, and IL-23 levels, hepatitis and renal function were measured in all study subjects. Independent t-test and Mann-Whitney tests were conducted to observe differences between groups.
A total of 78 liver cirrhosis patients were enrolled, mean age was 50.6±11.4. Median serum IL-6, IL-10, IL-12, and IL-23 levels were 24.5(2.6-46.4)pg/ml, 2.1(0.4-9.3)pg/ml, 3.5(1.4-20.8)pg/ml and 20.3(9.2-218)pg/ml, respectively. A higher IL-6 level was associated with more severe liver cirrhosis (p=0.001) and the presence of hepatic encephalopathy (p=0.018). Higher IL-23 level was found in patients with no hepatic encephalopathy (p=0.049). There was no association between serum cytokines levels and hepatitis viral infection status.
IL-6 is associated with the severity of liver cirrhosis.</abstract><cop>Bosnia and Herzegovina</cop><pub>Academy of Medical Sciences of Bosnia and Herzegovina</pub><pmid>34483450</pmid><doi>10.5455/medarh.2021.75.199-203</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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source | MEDLINE; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
subjects | Adult Ascites Cytokines Hepatitis B Hepatitis C Humans Infections Inflammation Interleukin-10 Interleukin-12 Interleukin-23 Interleukin-6 Internal medicine Laboratories Liver Cirrhosis Liver diseases Middle Aged Observational studies Original Paper Statistical analysis Viral infections |
title | Association Between Serum IL-6, IL-10, IL-12, and IL-23 Levels and Severity of Liver Cirrhosis |
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