Dual targeting of lymphocyte homing and retention through α4β7 and αEβ7 inhibition in inflammatory bowel disease

Anti-integrins are therapeutically effective for inflammatory bowel disease, yet the relative contribution of α4β7 and αEβ7 to gut lymphocyte trafficking is not fully elucidated. Here, we evaluate the effect of α4β7 and αEβ7 blockade using a combination of murine models of gut trafficking and longit...

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Veröffentlicht in:	Cell reports. Medicine 2021-08, Vol.2 (8), p.100381, Article 100381
Hauptverfasser:	Dai, Bingbing, Hackney, Jason A., Ichikawa, Ryan, Nguyen, Allen, Elstrott, Justin, Orozco, Luz D., Sun, Kai-Hui, Modrusan, Zora, Gogineni, Alvin, Scherl, Alexis, Gubatan, John, Habtezion, Aida, Deswal, Monika, Somsouk, Ma, Faubion, William A., Chai, Akiko, Sharafali, Zaineb, Hassanali, Azra, Oh, Young S., Tole, Swati, McBride, Jacqueline, Keir, Mary E., Yi, Tangsheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal, Humanized - pharmacology Biopsy Cadherins - metabolism CD8-Positive T-Lymphocytes Cell Communication Cell Movement Colon - pathology Epitopes - immunology etrolizumab Female Gene Expression Regulation - drug effects Inflammation - complications Inflammation - pathology inflammatory bowel disease Inflammatory Bowel Diseases - complications Inflammatory Bowel Diseases - immunology Inflammatory Bowel Diseases - pathology Integrins - metabolism Intestinal Mucosa - drug effects Intestinal Mucosa - immunology Intestinal Mucosa - pathology Lymph Nodes - pathology Lymphocytes - immunology Mice Mice, Inbred C57BL Mice, Transgenic T cell entry and retention T-Lymphocytes, Cytotoxic - drug effects α4β7 αEβ7
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