Absence of QTc Prolongation with Sodium N-(8-[2-Hydroxybenzoyl] Amino) Caprylate (SNAC), an Absorption Enhancer Co-Formulated with the GLP-1 Analogue Semaglutide for Oral Administration

Introduction Oral delivery of proteins, including glucagon-like peptide 1 (GLP-1) receptor agonists, is impeded by low gastrointestinal permeation. Oral semaglutide has been developed for once-daily oral administration by co-formulation of the GLP-1 analogue semaglutide with an absorption enhancer,...

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Veröffentlicht in:	Diabetes therapy 2021-09, Vol.12 (9), p.2599-2610
Hauptverfasser:	Granhall, Charlotte, Bækdal, Tine A., Breitschaft, Astrid, Søndergaard, Flemming L., Anderson, Thomas W., Thomsen, Mette
Format:	Artikel
Sprache:	eng
Schlagworte:	Antidiabetics Brief Report Cardiology Diabetes Endocrinology GLP-1 receptor agonists Internal Medicine Medicine Medicine & Public Health NCT NCT02911870 Oral administration
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