A five amino acids deletion in NKCC2 of C57BL/6 mice affects analysis of NKCC2 phosphorylation but does not impact kidney function

Aim The phosphorylation level of the furosemide‐sensitive Na+‐K+‐2Cl− cotransporter (NKCC2) in the thick ascending limb (TAL) is used as a surrogate marker for NKCC2 activation and TAL function. However, in mice, analyses of NKCC2 phosphorylation with antibodies against phosphorylated threonines 96...

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Veröffentlicht in:	Acta Physiologica 2021-09, Vol.233 (1), p.e13705-n/a
Hauptverfasser:	Moser, Sandra, Sugano, Yuya, Wengi, Agnieszka, Fisi, Viktoria, Lindtoft Rosenbaek, Lena, Mariniello, Marta, Loffing‐Cueni, Dominique, McCormick, James A., Fenton, Robert A., Loffing, Johannes
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Antibodies Furosemide ion homeostasis kidney Kidneys NKCC2 Nucleotide sequence Phenotyping Phosphorylation Protein transport Regular Paper Renal Physiology Sodium chloride strain differences
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