Cerebral Blood Flow in Chronic Kidney Disease
The prevalence of mild cognitive impairment increases with age and is further exacerbated by chronic kidney disease (CKD). CKD is associated with (1) mild cognitive impairment, (2) impaired endothelial function, (3) impaired blood-brain barrier, (4) increased cerebral microhemorrhage burden, (5) inc...
Gespeichert in:
| Veröffentlicht in: | Journal of stroke and cerebrovascular diseases 2021-09, Vol.30 (9), p.105702-105702, Article 105702 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 105702 |
|---|---|
| container_issue | 9 |
| container_start_page | 105702 |
| container_title | Journal of stroke and cerebrovascular diseases |
| container_volume | 30 |
| creator | Choi, Bernard Crouzet, Christian Lau, Wei Ling Cribbs, David H. Fisher, Mark J. |
| description | The prevalence of mild cognitive impairment increases with age and is further exacerbated by chronic kidney disease (CKD). CKD is associated with (1) mild cognitive impairment, (2) impaired endothelial function, (3) impaired blood-brain barrier, (4) increased cerebral microhemorrhage burden, (5) increased cerebral blood flow (CBF), (6) impaired cerebral autoregulation, (7) impaired cerebrovascular reactivity, and (8) increased arterial stiffness. We report preliminary findings from our group that demonstrate altered cerebrovascular reactivity in a mouse model of CKD-associated vascular calcification. The CBF of CKD mice increased more quickly in response to hypercapnia (p < 0.05) but then decreased prematurely during hypercapnia challenge (p < 0.05). Together, these results indicate that altered kidney function can lead to alterations in the cerebral microvasculature, and hence brain health. |
| doi_str_mv | 10.1016/j.jstrokecerebrovasdis.2021.105702 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8384649</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1052305721001051</els_id><sourcerecordid>2501475391</sourcerecordid><originalsourceid>FETCH-LOGICAL-c519t-ef8c0e2a4f52a775803c039229f8de2185570d9c543c1e364f6e6a15da043d9e3</originalsourceid><addsrcrecordid>eNqVkE1LAzEQhoMotn78BdmjCFszyWY_LoKtVsWCFz2HNJnV1O2mJtuK_95oqyh48TQD8_LMy0PICdABUMhPZ4NZ6Lx7Ro0ep96tVDA2DBhlEAOioGyL9EFwlpYCYDvuVLCUx0uP7IUwoxRAlGKX9DgvIMsL0Sfp6JOlmmTYOGeSceNeE9smoyfvWquTW2tafEsubEAV8IDs1KoJeLiZ--RhfHk_uk4nd1c3o_NJqgVUXYp1qSkyldWCqaIQJeWa8oqxqi4NMihFLGsqLTKuAXme1TnmCoRRNOOmQr5PztbcxXI6R6Ox7WJFufB2rvybdMrK35fWPslHt5IlL7M8qyLgeAPw7mWJoZNzGzQ2jWrRLYNkgkJWCF5BjA7XUe1dCB7r7zdA5Yd3OZN_eZcf3uXae4Qc_Sz8jfgSHQOTdQCjtpVFL4O22Go01qPupHH2P__eAU1Coc8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2501475391</pqid></control><display><type>article</type><title>Cerebral Blood Flow in Chronic Kidney Disease</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Choi, Bernard ; Crouzet, Christian ; Lau, Wei Ling ; Cribbs, David H. ; Fisher, Mark J.</creator><creatorcontrib>Choi, Bernard ; Crouzet, Christian ; Lau, Wei Ling ; Cribbs, David H. ; Fisher, Mark J.</creatorcontrib><description>The prevalence of mild cognitive impairment increases with age and is further exacerbated by chronic kidney disease (CKD). CKD is associated with (1) mild cognitive impairment, (2) impaired endothelial function, (3) impaired blood-brain barrier, (4) increased cerebral microhemorrhage burden, (5) increased cerebral blood flow (CBF), (6) impaired cerebral autoregulation, (7) impaired cerebrovascular reactivity, and (8) increased arterial stiffness. We report preliminary findings from our group that demonstrate altered cerebrovascular reactivity in a mouse model of CKD-associated vascular calcification. The CBF of CKD mice increased more quickly in response to hypercapnia (p < 0.05) but then decreased prematurely during hypercapnia challenge (p < 0.05). Together, these results indicate that altered kidney function can lead to alterations in the cerebral microvasculature, and hence brain health.</description><identifier>ISSN: 1052-3057</identifier><identifier>EISSN: 1532-8511</identifier><identifier>DOI: 10.1016/j.jstrokecerebrovasdis.2021.105702</identifier><identifier>PMID: 33714675</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Cerebral Arteries - physiopathology ; Cerebral blood flow ; Cerebrovascular Circulation ; Cerebrovascular Disorders - etiology ; Cerebrovascular Disorders - physiopathology ; Chronic kidney disease ; Cognition ; Cognitive Dysfunction - etiology ; Cognitive Dysfunction - physiopathology ; Cognitive Dysfunction - psychology ; Disease Models, Animal ; Female ; Homeostasis ; Humans ; Hypercapnia - complications ; Hypercapnia - physiopathology ; Kidney - physiopathology ; Laser speckle contrast imaging ; Mice ; Mice, Inbred DBA ; Microcirculation ; Renal Insufficiency, Chronic - complications ; Renal Insufficiency, Chronic - physiopathology ; Speckle contrast ; Vascular dysfunction ; Vasomotor reactivity</subject><ispartof>Journal of stroke and cerebrovascular diseases, 2021-09, Vol.30 (9), p.105702-105702, Article 105702</ispartof><rights>2021 Elsevier Inc.</rights><rights>Copyright © 2021 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c519t-ef8c0e2a4f52a775803c039229f8de2185570d9c543c1e364f6e6a15da043d9e3</citedby><cites>FETCH-LOGICAL-c519t-ef8c0e2a4f52a775803c039229f8de2185570d9c543c1e364f6e6a15da043d9e3</cites><orcidid>0000-0002-3118-1073 ; 0000-0002-4380-8291 ; 0000-0002-6870-4480</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2021.105702$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33714675$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choi, Bernard</creatorcontrib><creatorcontrib>Crouzet, Christian</creatorcontrib><creatorcontrib>Lau, Wei Ling</creatorcontrib><creatorcontrib>Cribbs, David H.</creatorcontrib><creatorcontrib>Fisher, Mark J.</creatorcontrib><title>Cerebral Blood Flow in Chronic Kidney Disease</title><title>Journal of stroke and cerebrovascular diseases</title><addtitle>J Stroke Cerebrovasc Dis</addtitle><description>The prevalence of mild cognitive impairment increases with age and is further exacerbated by chronic kidney disease (CKD). CKD is associated with (1) mild cognitive impairment, (2) impaired endothelial function, (3) impaired blood-brain barrier, (4) increased cerebral microhemorrhage burden, (5) increased cerebral blood flow (CBF), (6) impaired cerebral autoregulation, (7) impaired cerebrovascular reactivity, and (8) increased arterial stiffness. We report preliminary findings from our group that demonstrate altered cerebrovascular reactivity in a mouse model of CKD-associated vascular calcification. The CBF of CKD mice increased more quickly in response to hypercapnia (p < 0.05) but then decreased prematurely during hypercapnia challenge (p < 0.05). Together, these results indicate that altered kidney function can lead to alterations in the cerebral microvasculature, and hence brain health.</description><subject>Animals</subject><subject>Cerebral Arteries - physiopathology</subject><subject>Cerebral blood flow</subject><subject>Cerebrovascular Circulation</subject><subject>Cerebrovascular Disorders - etiology</subject><subject>Cerebrovascular Disorders - physiopathology</subject><subject>Chronic kidney disease</subject><subject>Cognition</subject><subject>Cognitive Dysfunction - etiology</subject><subject>Cognitive Dysfunction - physiopathology</subject><subject>Cognitive Dysfunction - psychology</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Hypercapnia - complications</subject><subject>Hypercapnia - physiopathology</subject><subject>Kidney - physiopathology</subject><subject>Laser speckle contrast imaging</subject><subject>Mice</subject><subject>Mice, Inbred DBA</subject><subject>Microcirculation</subject><subject>Renal Insufficiency, Chronic - complications</subject><subject>Renal Insufficiency, Chronic - physiopathology</subject><subject>Speckle contrast</subject><subject>Vascular dysfunction</subject><subject>Vasomotor reactivity</subject><issn>1052-3057</issn><issn>1532-8511</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkE1LAzEQhoMotn78BdmjCFszyWY_LoKtVsWCFz2HNJnV1O2mJtuK_95oqyh48TQD8_LMy0PICdABUMhPZ4NZ6Lx7Ro0ep96tVDA2DBhlEAOioGyL9EFwlpYCYDvuVLCUx0uP7IUwoxRAlGKX9DgvIMsL0Sfp6JOlmmTYOGeSceNeE9smoyfvWquTW2tafEsubEAV8IDs1KoJeLiZ--RhfHk_uk4nd1c3o_NJqgVUXYp1qSkyldWCqaIQJeWa8oqxqi4NMihFLGsqLTKuAXme1TnmCoRRNOOmQr5PztbcxXI6R6Ox7WJFufB2rvybdMrK35fWPslHt5IlL7M8qyLgeAPw7mWJoZNzGzQ2jWrRLYNkgkJWCF5BjA7XUe1dCB7r7zdA5Yd3OZN_eZcf3uXae4Qc_Sz8jfgSHQOTdQCjtpVFL4O22Go01qPupHH2P__eAU1Coc8</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Choi, Bernard</creator><creator>Crouzet, Christian</creator><creator>Lau, Wei Ling</creator><creator>Cribbs, David H.</creator><creator>Fisher, Mark J.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3118-1073</orcidid><orcidid>https://orcid.org/0000-0002-4380-8291</orcidid><orcidid>https://orcid.org/0000-0002-6870-4480</orcidid></search><sort><creationdate>20210901</creationdate><title>Cerebral Blood Flow in Chronic Kidney Disease</title><author>Choi, Bernard ; Crouzet, Christian ; Lau, Wei Ling ; Cribbs, David H. ; Fisher, Mark J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c519t-ef8c0e2a4f52a775803c039229f8de2185570d9c543c1e364f6e6a15da043d9e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Cerebral Arteries - physiopathology</topic><topic>Cerebral blood flow</topic><topic>Cerebrovascular Circulation</topic><topic>Cerebrovascular Disorders - etiology</topic><topic>Cerebrovascular Disorders - physiopathology</topic><topic>Chronic kidney disease</topic><topic>Cognition</topic><topic>Cognitive Dysfunction - etiology</topic><topic>Cognitive Dysfunction - physiopathology</topic><topic>Cognitive Dysfunction - psychology</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Hypercapnia - complications</topic><topic>Hypercapnia - physiopathology</topic><topic>Kidney - physiopathology</topic><topic>Laser speckle contrast imaging</topic><topic>Mice</topic><topic>Mice, Inbred DBA</topic><topic>Microcirculation</topic><topic>Renal Insufficiency, Chronic - complications</topic><topic>Renal Insufficiency, Chronic - physiopathology</topic><topic>Speckle contrast</topic><topic>Vascular dysfunction</topic><topic>Vasomotor reactivity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choi, Bernard</creatorcontrib><creatorcontrib>Crouzet, Christian</creatorcontrib><creatorcontrib>Lau, Wei Ling</creatorcontrib><creatorcontrib>Cribbs, David H.</creatorcontrib><creatorcontrib>Fisher, Mark J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of stroke and cerebrovascular diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, Bernard</au><au>Crouzet, Christian</au><au>Lau, Wei Ling</au><au>Cribbs, David H.</au><au>Fisher, Mark J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerebral Blood Flow in Chronic Kidney Disease</atitle><jtitle>Journal of stroke and cerebrovascular diseases</jtitle><addtitle>J Stroke Cerebrovasc Dis</addtitle><date>2021-09-01</date><risdate>2021</risdate><volume>30</volume><issue>9</issue><spage>105702</spage><epage>105702</epage><pages>105702-105702</pages><artnum>105702</artnum><issn>1052-3057</issn><eissn>1532-8511</eissn><abstract>The prevalence of mild cognitive impairment increases with age and is further exacerbated by chronic kidney disease (CKD). CKD is associated with (1) mild cognitive impairment, (2) impaired endothelial function, (3) impaired blood-brain barrier, (4) increased cerebral microhemorrhage burden, (5) increased cerebral blood flow (CBF), (6) impaired cerebral autoregulation, (7) impaired cerebrovascular reactivity, and (8) increased arterial stiffness. We report preliminary findings from our group that demonstrate altered cerebrovascular reactivity in a mouse model of CKD-associated vascular calcification. The CBF of CKD mice increased more quickly in response to hypercapnia (p < 0.05) but then decreased prematurely during hypercapnia challenge (p < 0.05). Together, these results indicate that altered kidney function can lead to alterations in the cerebral microvasculature, and hence brain health.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>33714675</pmid><doi>10.1016/j.jstrokecerebrovasdis.2021.105702</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-3118-1073</orcidid><orcidid>https://orcid.org/0000-0002-4380-8291</orcidid><orcidid>https://orcid.org/0000-0002-6870-4480</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1052-3057 |
| ispartof | Journal of stroke and cerebrovascular diseases, 2021-09, Vol.30 (9), p.105702-105702, Article 105702 |
| issn | 1052-3057 1532-8511 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8384649 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Cerebral Arteries - physiopathology Cerebral blood flow Cerebrovascular Circulation Cerebrovascular Disorders - etiology Cerebrovascular Disorders - physiopathology Chronic kidney disease Cognition Cognitive Dysfunction - etiology Cognitive Dysfunction - physiopathology Cognitive Dysfunction - psychology Disease Models, Animal Female Homeostasis Humans Hypercapnia - complications Hypercapnia - physiopathology Kidney - physiopathology Laser speckle contrast imaging Mice Mice, Inbred DBA Microcirculation Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - physiopathology Speckle contrast Vascular dysfunction Vasomotor reactivity |
| title | Cerebral Blood Flow in Chronic Kidney Disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T07%3A25%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cerebral%20Blood%20Flow%20in%20Chronic%20Kidney%20Disease&rft.jtitle=Journal%20of%20stroke%20and%20cerebrovascular%20diseases&rft.au=Choi,%20Bernard&rft.date=2021-09-01&rft.volume=30&rft.issue=9&rft.spage=105702&rft.epage=105702&rft.pages=105702-105702&rft.artnum=105702&rft.issn=1052-3057&rft.eissn=1532-8511&rft_id=info:doi/10.1016/j.jstrokecerebrovasdis.2021.105702&rft_dat=%3Cproquest_pubme%3E2501475391%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2501475391&rft_id=info:pmid/33714675&rft_els_id=S1052305721001051&rfr_iscdi=true |