Enhancer Pleiotropy, Gene Expression, and the Architecture of Human Enhancer–Gene Interactions

Abstract Enhancers are often studied as noncoding regulatory elements that modulate the precise spatiotemporal expression of genes in a highly tissue-specific manner. This paradigm has been challenged by recent evidence of individual enhancers acting in multiple tissues or developmental contexts. Ho...

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Veröffentlicht in:	Molecular biology and evolution 2021-09, Vol.38 (9), p.3898-3909
Hauptverfasser:	Singh, Devika, Yi, Soojin V
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biological Evolution Chromatin Discoveries Enhancer Elements, Genetic Gene Expression Genes Genetic transcription Genome, Human Genomics Humans Transcription Factors - genetics
Online-Zugang:	Volltext
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