Sex-Specific Association of the X Chromosome With Cognitive Change and Tau Pathology in Aging and Alzheimer Disease

IMPORTANCE: The X chromosome represents 5% of the human genome in women and men, and its influence on cognitive aging and Alzheimer disease (AD) is largely unknown. OBJECTIVE: To determine whether the X chromosome is associated with sex-specific cognitive change and tau pathology in aging and AD. DE...

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Veröffentlicht in:	Archives of neurology (Chicago) 2021-10, Vol.78 (10), p.1249-1254
Hauptverfasser:	Davis, Emily J, Solsberg, Caroline W, White, Charles C, Miñones-Moyano, Elena, Sirota, Marina, Chibnik, Lori, Bennett, David A, De Jager, Philip L, Yokoyama, Jennifer S, Dubal, Dena B
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged Aged, 80 and over Aging Aging - physiology Alzheimer Disease - genetics Alzheimer Disease - pathology Alzheimer's disease Autopsies Brief Report Chromosomes Chromosomes, Human, X Cognition Cognition & reasoning Cognitive ability Cognitive Dysfunction Cohort Studies Comments Death Diagnosis Dorsolateral Prefrontal Cortex Education Female Gene expression Gene sequencing Genes Genomes Geriatrics Humans Male Memory Men Middle Aged Mortality Neurodegenerative diseases Neurofibrillary Tangles - pathology Neuropathology Older people Online First Pathology Prefrontal cortex Ribonucleic acid RNA Sex Sex Characteristics Tau protein Transcriptome Transcriptomes Women X chromosomes
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