Impact of age and gender on the efficacy and safety of upfront therapy with panitumumab plus FOLFOX followed by panitumumab-based maintenance: a pre-specified subgroup analysis of the Valentino study

The safety and efficacy outcome of elderly metastatic colorectal cancer (mCRC) patients fit enough to receive combination chemotherapy plus biological agents is an issue of growing interest. Also, gender-specific differential toxicity and efficacy of anti-epidermal growth factor receptor (EGFR)-base...

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Veröffentlicht in:	ESMO open 2021-10, Vol.6 (5), p.100246, Article 100246
Hauptverfasser:	Raimondi, A., Fucà, G., Leone, A.G., Lonardi, S., Antoniotti, C., Smiroldo, V., Amatu, A., Tampellini, M., Ritorto, G., Murialdo, R., Clavarezza, M., Zaniboni, A., Berenato, R., Ratti, M., Corallo, S., Morano, F., Di Bartolomeo, M., Di Maio, M., Pietrantonio, F.
Format:	Artikel
Sprache:	eng
Schlagworte:	age Aged anti-EGFR Antineoplastic Combined Chemotherapy Protocols - adverse effects colorectal cancer Colorectal Neoplasms - drug therapy Female Fluorouracil - adverse effects gender Humans Male metastasis Original Research Panitumumab - therapeutic use Quality of Life
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