The Relation of ABO Blood Group to the Severity of Coronavirus Disease: A Cross-Sectional Study From a Tertiary Care Hospital in Karachi
Background Blood groups are considered to have an impact on the occurrence and severity of coronavirus disease. While among Chinese and Caucasian, blood group O individuals were less and group A were more likely to have severe disease and mortality, data on South Asians aren’t available. Objective...
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| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2021-07, Vol.13 (7), p.e16598-e16598 |
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| creator | Rehman, Fazal U Omair, Syed Furrukh Memon, Fatima Rind, Bakhtawar J Memon, Danish Ahmed Ali, Syed Ahsan Ahmed, Bilal Ali, Naureen |
| description | Background
Blood groups are considered to have an impact on the occurrence and severity of coronavirus disease. While among Chinese and Caucasian, blood group O individuals were less and group A were more likely to have severe disease and mortality, data on South Asians aren’t available.
Objective
This study aimed to find out the association of disease severity with blood group among coronavirus disease 2019 (COVID-19) patients.
Materials and methodology
Data were collected on a predesigned questionnaire containing details of patient demographics, medical comorbidities, clinical presentation, and laboratory parameters. Multiple logistic regression was used to determine the association of the blood group with the severity of coronavirus disease.
Result
Among the study participants, blood group B has the highest distribution (39.8%), followed by O (30.0), A (21.9%), and AB (8.1%). About three-fourths (69.9%) had mild to moderate disease while 30.0% had severe disease. Age, gender, hypertension, diabetes mellitus, and hemoglobin level were all associated with disease severity among COVID-19 patients in univariate analysis on P-value for selection ( |
| doi_str_mv | 10.7759/cureus.16598 |
| format | Article |
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Blood groups are considered to have an impact on the occurrence and severity of coronavirus disease. While among Chinese and Caucasian, blood group O individuals were less and group A were more likely to have severe disease and mortality, data on South Asians aren’t available.
Objective
This study aimed to find out the association of disease severity with blood group among coronavirus disease 2019 (COVID-19) patients.
Materials and methodology
Data were collected on a predesigned questionnaire containing details of patient demographics, medical comorbidities, clinical presentation, and laboratory parameters. Multiple logistic regression was used to determine the association of the blood group with the severity of coronavirus disease.
Result
Among the study participants, blood group B has the highest distribution (39.8%), followed by O (30.0), A (21.9%), and AB (8.1%). About three-fourths (69.9%) had mild to moderate disease while 30.0% had severe disease. Age, gender, hypertension, diabetes mellitus, and hemoglobin level were all associated with disease severity among COVID-19 patients in univariate analysis on P-value for selection (<0.25). The final model showed that the odds of disease severity is 3.62 times higher among males (OR: 3.62, 95% CI: 2.15-6.08) and 2.00 times higher among diabetic patients (OR: 2.00, 95% CI: 1.10-3.01) as compared to female and non-diabetic respectively. However, there was no significant association found between blood group and disease severity.
Conclusion
Blood groups don’t have any role in forecasting the severity of coronavirus disease. However, the male gender and diabetics are prone to have severe disease.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.16598</identifier><identifier>PMID: 34430180</identifier><language>eng</language><publisher>Palo Alto (CA): Cureus</publisher><subject>Hematology ; Infectious Disease</subject><ispartof>Curēus (Palo Alto, CA), 2021-07, Vol.13 (7), p.e16598-e16598</ispartof><rights>Copyright © 2021, Rehman et al. 2021 Rehman et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c248t-c7e4ddb3291cd85226bd176d1d236732d37b26e320795d7a057b421914c81d083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378412/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378412/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Rehman, Fazal U</creatorcontrib><creatorcontrib>Omair, Syed Furrukh</creatorcontrib><creatorcontrib>Memon, Fatima</creatorcontrib><creatorcontrib>Rind, Bakhtawar J</creatorcontrib><creatorcontrib>Memon, Danish Ahmed</creatorcontrib><creatorcontrib>Ali, Syed Ahsan</creatorcontrib><creatorcontrib>Ahmed, Bilal</creatorcontrib><creatorcontrib>Ali, Naureen</creatorcontrib><title>The Relation of ABO Blood Group to the Severity of Coronavirus Disease: A Cross-Sectional Study From a Tertiary Care Hospital in Karachi</title><title>Curēus (Palo Alto, CA)</title><description>Background
Blood groups are considered to have an impact on the occurrence and severity of coronavirus disease. While among Chinese and Caucasian, blood group O individuals were less and group A were more likely to have severe disease and mortality, data on South Asians aren’t available.
Objective
This study aimed to find out the association of disease severity with blood group among coronavirus disease 2019 (COVID-19) patients.
Materials and methodology
Data were collected on a predesigned questionnaire containing details of patient demographics, medical comorbidities, clinical presentation, and laboratory parameters. Multiple logistic regression was used to determine the association of the blood group with the severity of coronavirus disease.
Result
Among the study participants, blood group B has the highest distribution (39.8%), followed by O (30.0), A (21.9%), and AB (8.1%). About three-fourths (69.9%) had mild to moderate disease while 30.0% had severe disease. Age, gender, hypertension, diabetes mellitus, and hemoglobin level were all associated with disease severity among COVID-19 patients in univariate analysis on P-value for selection (<0.25). The final model showed that the odds of disease severity is 3.62 times higher among males (OR: 3.62, 95% CI: 2.15-6.08) and 2.00 times higher among diabetic patients (OR: 2.00, 95% CI: 1.10-3.01) as compared to female and non-diabetic respectively. However, there was no significant association found between blood group and disease severity.
Conclusion
Blood groups don’t have any role in forecasting the severity of coronavirus disease. However, the male gender and diabetics are prone to have severe disease.</description><subject>Hematology</subject><subject>Infectious Disease</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpVkctuEzEUhi0EolXpjgc4SxZM8W3GHhZI6UAvolIlEtaWxz4hRpNxsD2R8gY8NpOmQrDykfzpO5efkLeMXilVtx_clHDKV6ypW_2CnHPW6EozLV_-U5-Ry5x_UkoZVZwq-pqcCSkFZZqek9-rDcI3HGwJcYS4hsX1I1wPMXq4TXHaQYlQZmSJe0yhHI5IF1Mc7T6kKcPnkNFm_AgL6FLMuVqiO6rsAMsy-QPcpLgFCytMJdh0gM4mhLuYd6HMTBjhq03WbcIb8mpth4yXz-8F-X7zZdXdVQ-Pt_fd4qFyXOpSOYXS-17wljmva86b3jPVeOa5aJTgXqieNyjmRdvaK0tr1UvOWiadZp5qcUE-nby7qd-idziWZAezS2E7j2eiDeb_nzFszI-4N1ooLRmfBe-eBSn-mjAXsw3Z4TDYEeOUDa8bKXXDKZ3R9yfUHU-TcP23DaPmmJ855Wee8hN_AOC6jgU</recordid><startdate>20210723</startdate><enddate>20210723</enddate><creator>Rehman, Fazal U</creator><creator>Omair, Syed Furrukh</creator><creator>Memon, Fatima</creator><creator>Rind, Bakhtawar J</creator><creator>Memon, Danish Ahmed</creator><creator>Ali, Syed Ahsan</creator><creator>Ahmed, Bilal</creator><creator>Ali, Naureen</creator><general>Cureus</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210723</creationdate><title>The Relation of ABO Blood Group to the Severity of Coronavirus Disease: A Cross-Sectional Study From a Tertiary Care Hospital in Karachi</title><author>Rehman, Fazal U ; Omair, Syed Furrukh ; Memon, Fatima ; Rind, Bakhtawar J ; Memon, Danish Ahmed ; Ali, Syed Ahsan ; Ahmed, Bilal ; Ali, Naureen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c248t-c7e4ddb3291cd85226bd176d1d236732d37b26e320795d7a057b421914c81d083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Hematology</topic><topic>Infectious Disease</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rehman, Fazal U</creatorcontrib><creatorcontrib>Omair, Syed Furrukh</creatorcontrib><creatorcontrib>Memon, Fatima</creatorcontrib><creatorcontrib>Rind, Bakhtawar J</creatorcontrib><creatorcontrib>Memon, Danish Ahmed</creatorcontrib><creatorcontrib>Ali, Syed Ahsan</creatorcontrib><creatorcontrib>Ahmed, Bilal</creatorcontrib><creatorcontrib>Ali, Naureen</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rehman, Fazal U</au><au>Omair, Syed Furrukh</au><au>Memon, Fatima</au><au>Rind, Bakhtawar J</au><au>Memon, Danish Ahmed</au><au>Ali, Syed Ahsan</au><au>Ahmed, Bilal</au><au>Ali, Naureen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Relation of ABO Blood Group to the Severity of Coronavirus Disease: A Cross-Sectional Study From a Tertiary Care Hospital in Karachi</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><date>2021-07-23</date><risdate>2021</risdate><volume>13</volume><issue>7</issue><spage>e16598</spage><epage>e16598</epage><pages>e16598-e16598</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>Background
Blood groups are considered to have an impact on the occurrence and severity of coronavirus disease. While among Chinese and Caucasian, blood group O individuals were less and group A were more likely to have severe disease and mortality, data on South Asians aren’t available.
Objective
This study aimed to find out the association of disease severity with blood group among coronavirus disease 2019 (COVID-19) patients.
Materials and methodology
Data were collected on a predesigned questionnaire containing details of patient demographics, medical comorbidities, clinical presentation, and laboratory parameters. Multiple logistic regression was used to determine the association of the blood group with the severity of coronavirus disease.
Result
Among the study participants, blood group B has the highest distribution (39.8%), followed by O (30.0), A (21.9%), and AB (8.1%). About three-fourths (69.9%) had mild to moderate disease while 30.0% had severe disease. Age, gender, hypertension, diabetes mellitus, and hemoglobin level were all associated with disease severity among COVID-19 patients in univariate analysis on P-value for selection (<0.25). The final model showed that the odds of disease severity is 3.62 times higher among males (OR: 3.62, 95% CI: 2.15-6.08) and 2.00 times higher among diabetic patients (OR: 2.00, 95% CI: 1.10-3.01) as compared to female and non-diabetic respectively. However, there was no significant association found between blood group and disease severity.
Conclusion
Blood groups don’t have any role in forecasting the severity of coronavirus disease. However, the male gender and diabetics are prone to have severe disease.</abstract><cop>Palo Alto (CA)</cop><pub>Cureus</pub><pmid>34430180</pmid><doi>10.7759/cureus.16598</doi><oa>free_for_read</oa></addata></record> |
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| source | PubMed Central Open Access; PubMed Central |
| subjects | Hematology Infectious Disease |
| title | The Relation of ABO Blood Group to the Severity of Coronavirus Disease: A Cross-Sectional Study From a Tertiary Care Hospital in Karachi |
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