Naringin and Hesperidin Counteract Diclofenac-Induced Hepatotoxicity in Male Wistar Rats via Their Antioxidant, Anti-Inflammatory, and Antiapoptotic Activities

This study is aimed at evaluating the preventive effect and at suggesting the mode of actions of naringin and hesperidin and their combination in diclofenac-induced hepatotoxicity. Male Wistar rats, intraperitoneally injected with diclofenac sodium (3 mg/kg b.wt/day), were orally treated with naring...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2021, Vol.2021 (1), p.9990091-9990091
Hauptverfasser:	Hassan, Rasha A., Hozayen, Walaa G., Abo Sree, Haidy T., Al-Muzafar, Hessah M., Amin, Kamal A., Ahmed, Osama M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents, Non-Steroidal - toxicity Antioxidants Antioxidants - pharmacology Apoptosis Chemical and Drug Induced Liver Injury - drug therapy Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - pathology Citrus fruits Cytokines Cytokines - metabolism Diclofenac - toxicity Dietary minerals Drug dosages Flavanones - pharmacology Flavonoids Hesperidin - pharmacology Inflammation Liver Male Nonsteroidal anti-inflammatory drugs Oxidative Stress Prevention Rats Rats, Wistar
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