Enhanced silver diamine fluoride therapy using the PILP method —A nanoindentation study
The aim of this study was to evaluate the feasibility of applying the polymer-induced liquid-precursor (PILP) method to enhance silver diamine fluoride (SDF) therapy. One hundred forty micrometer deep artificial caries lesions were treated with (A) 38% SDF solution and (B) 38% SDF containing poly-L-...
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| Veröffentlicht in: | Dental Materials Journal 2020/11/27, Vol.39(6), pp.1009-1015 |
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| creator | NURROHMAN, Hamid HABELITZ, Stefan SAEKI, Kuniko SADR, Alireza GOWER, Laurie B. PAZDERNIK, Vanessa TAGAMI, Junji MARSHALL, Sally J. MARSHALL, Grayson W. |
| description | The aim of this study was to evaluate the feasibility of applying the polymer-induced liquid-precursor (PILP) method to enhance silver diamine fluoride (SDF) therapy. One hundred forty micrometer deep artificial caries lesions were treated with (A) 38% SDF solution and (B) 38% SDF containing poly-L-aspartic acid (pASP). Changes in the nanomechanical profile across the lesion were evaluated. Hydrated artificial lesions had a low reduced elastic modulus (0.3 GPa) and nanohardness (0.02 GPa) region extending about 100 μm into the lesion, with a gradual linear increase to about 168 μm where the values plateaued to around 18 GPa/1.0 GPa. Topical application of SDF resulted in significantly recovered properties (p |
| doi_str_mv | 10.4012/dmj.2019-273 |
| format | Article |
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T. Still University ; Department of Research Support ; University of California San Francisco ; University of Washington School of Dentistry</creatorcontrib><description>The aim of this study was to evaluate the feasibility of applying the polymer-induced liquid-precursor (PILP) method to enhance silver diamine fluoride (SDF) therapy. One hundred forty micrometer deep artificial caries lesions were treated with (A) 38% SDF solution and (B) 38% SDF containing poly-L-aspartic acid (pASP). Changes in the nanomechanical profile across the lesion were evaluated. Hydrated artificial lesions had a low reduced elastic modulus (0.3 GPa) and nanohardness (0.02 GPa) region extending about 100 μm into the lesion, with a gradual linear increase to about 168 μm where the values plateaued to around 18 GPa/1.0 GPa. Topical application of SDF resulted in significantly recovered properties (p<0.001). SDF containing pASP resulted in greater nanomechanical properties compared to SDF alone, showing similar sloped regions up to 96 μm, then SDF alone dropped while SDF containing pASP continued at a modest slope until reaching normal at 144 μm. This nanoindentation study shows enhanced SDF therapy using the PILP method.</description><identifier>ISSN: 0287-4547</identifier><identifier>EISSN: 1881-1361</identifier><identifier>DOI: 10.4012/dmj.2019-273</identifier><identifier>PMID: 32624525</identifier><language>eng</language><publisher>Japan: The Japanese Society for Dental Materials and Devices</publisher><subject>Artificial caries dentin lesion ; Aspartic acid ; Caries arrest ; Cariostatic Agents ; Dental caries ; Dental Caries - prevention & control ; Dentin ; Diamines ; Fluoride treatments ; Fluorides ; Fluorides, Topical ; Humans ; Lesions ; Mechanical properties ; Modulus of elasticity ; Nanohardness ; Nanoindentation ; Nanomechanical recovery ; Polymer-induced liquid-precursor ; Polymers ; Prepolymers ; Quaternary Ammonium Compounds ; Silver Compounds ; Silver diamine fluoride ; Therapy ; Topical application</subject><ispartof>Dental Materials Journal, 2020/11/27, Vol.39(6), pp.1009-1015</ispartof><rights>2020 The Japanese Society for Dental Materials and Devices</rights><rights>Copyright Japan Science and Technology Agency 2020</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c726t-ef56e228c7e7a613818be7f235bbff11ffeedccad72e7fdcc231b4402ba73a583</citedby><cites>FETCH-LOGICAL-c726t-ef56e228c7e7a613818be7f235bbff11ffeedccad72e7fdcc231b4402ba73a583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32624525$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NURROHMAN, Hamid</creatorcontrib><creatorcontrib>HABELITZ, Stefan</creatorcontrib><creatorcontrib>SAEKI, Kuniko</creatorcontrib><creatorcontrib>SADR, Alireza</creatorcontrib><creatorcontrib>GOWER, Laurie B.</creatorcontrib><creatorcontrib>PAZDERNIK, Vanessa</creatorcontrib><creatorcontrib>TAGAMI, Junji</creatorcontrib><creatorcontrib>MARSHALL, Sally J.</creatorcontrib><creatorcontrib>MARSHALL, Grayson W.</creatorcontrib><creatorcontrib>Department of Preventive and Restorative Dental Sciences</creatorcontrib><creatorcontrib>Biomimetics Biomaterials Biophotonics & Technology Laboratory</creatorcontrib><creatorcontrib>Department of Restorative Dentistry</creatorcontrib><creatorcontrib>University of Florida</creatorcontrib><creatorcontrib>Graduate School of Medical and Dental Sciences</creatorcontrib><creatorcontrib>Missouri School of Dentistry and Oral Health</creatorcontrib><creatorcontrib>Materials Science and Engineering Department</creatorcontrib><creatorcontrib>Department of Cariology and Operative Dentistry</creatorcontrib><creatorcontrib>Tokyo Medical and Dental University</creatorcontrib><creatorcontrib>A. T. Still University</creatorcontrib><creatorcontrib>Department of Research Support</creatorcontrib><creatorcontrib>University of California San Francisco</creatorcontrib><creatorcontrib>University of Washington School of Dentistry</creatorcontrib><title>Enhanced silver diamine fluoride therapy using the PILP method —A nanoindentation study</title><title>Dental Materials Journal</title><addtitle>Dent. Mater. J.</addtitle><description>The aim of this study was to evaluate the feasibility of applying the polymer-induced liquid-precursor (PILP) method to enhance silver diamine fluoride (SDF) therapy. One hundred forty micrometer deep artificial caries lesions were treated with (A) 38% SDF solution and (B) 38% SDF containing poly-L-aspartic acid (pASP). Changes in the nanomechanical profile across the lesion were evaluated. Hydrated artificial lesions had a low reduced elastic modulus (0.3 GPa) and nanohardness (0.02 GPa) region extending about 100 μm into the lesion, with a gradual linear increase to about 168 μm where the values plateaued to around 18 GPa/1.0 GPa. Topical application of SDF resulted in significantly recovered properties (p<0.001). SDF containing pASP resulted in greater nanomechanical properties compared to SDF alone, showing similar sloped regions up to 96 μm, then SDF alone dropped while SDF containing pASP continued at a modest slope until reaching normal at 144 μm. This nanoindentation study shows enhanced SDF therapy using the PILP method.</description><subject>Artificial caries dentin lesion</subject><subject>Aspartic acid</subject><subject>Caries arrest</subject><subject>Cariostatic Agents</subject><subject>Dental caries</subject><subject>Dental Caries - prevention & control</subject><subject>Dentin</subject><subject>Diamines</subject><subject>Fluoride treatments</subject><subject>Fluorides</subject><subject>Fluorides, Topical</subject><subject>Humans</subject><subject>Lesions</subject><subject>Mechanical properties</subject><subject>Modulus of elasticity</subject><subject>Nanohardness</subject><subject>Nanoindentation</subject><subject>Nanomechanical recovery</subject><subject>Polymer-induced liquid-precursor</subject><subject>Polymers</subject><subject>Prepolymers</subject><subject>Quaternary Ammonium Compounds</subject><subject>Silver Compounds</subject><subject>Silver diamine fluoride</subject><subject>Therapy</subject><subject>Topical application</subject><issn>0287-4547</issn><issn>1881-1361</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkctu1DAUhi0EosPAjjWyxIYFKb4ktrNBKlUplUaiC1iwspz4ZMajxB7spNLseAiekCfBmWmHy8a38-k_v8-P0EtKzktC2Ts7bM8ZoXXBJH-EFlQpWlAu6GO0IEzJoqxKeYaepbQlpKyFUk_RGWeClRWrFujbld8Y34LFyfV3ELF1ZnAecNdPIToLeNxANLs9npLz6_mGb29Wt3iAcRMs_vXj5wX2xgfnLfjRjC54nMbJ7p-jJ53pE7y435fo68erL5efitXn65vLi1XRSibGArpKAGOqlSCNoFxR1YDsGK-apuso7ToA27bGSpaf84lx2pQlYY2R3FSKL9H7o-5uaoaMZhfR9HoX3WDiXgfj9L8V7zZ6He604lJQVWeBN_cCMXyfII16cKmFvjcewpQ0KxnJ45J5vkv0-j90G6bo8_cyJQSRlB8cvT1SbQwpRehOZijRc2Y6Z6bnzHTWzPirvz9wgh9CysD1EchV15o--D4n9Ke13ZM8-4MkI5oQXhOhCeW5HanzQisuasbk7P_DUWmbRrOGUysTR9f2cPDFay3m5cHfqdhuTNTg-W9X2ML3</recordid><startdate>20201127</startdate><enddate>20201127</enddate><creator>NURROHMAN, Hamid</creator><creator>HABELITZ, Stefan</creator><creator>SAEKI, Kuniko</creator><creator>SADR, Alireza</creator><creator>GOWER, Laurie B.</creator><creator>PAZDERNIK, Vanessa</creator><creator>TAGAMI, Junji</creator><creator>MARSHALL, Sally J.</creator><creator>MARSHALL, Grayson W.</creator><general>The Japanese Society for Dental Materials and Devices</general><general>Japanese Society for Dental Materials and Devices</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20201127</creationdate><title>Enhanced silver diamine fluoride therapy using the PILP method —A nanoindentation study</title><author>NURROHMAN, Hamid ; HABELITZ, Stefan ; SAEKI, Kuniko ; SADR, Alireza ; GOWER, Laurie B. ; PAZDERNIK, Vanessa ; TAGAMI, Junji ; MARSHALL, Sally J. ; MARSHALL, Grayson W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c726t-ef56e228c7e7a613818be7f235bbff11ffeedccad72e7fdcc231b4402ba73a583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Artificial caries dentin lesion</topic><topic>Aspartic acid</topic><topic>Caries arrest</topic><topic>Cariostatic Agents</topic><topic>Dental caries</topic><topic>Dental Caries - prevention & control</topic><topic>Dentin</topic><topic>Diamines</topic><topic>Fluoride treatments</topic><topic>Fluorides</topic><topic>Fluorides, Topical</topic><topic>Humans</topic><topic>Lesions</topic><topic>Mechanical properties</topic><topic>Modulus of elasticity</topic><topic>Nanohardness</topic><topic>Nanoindentation</topic><topic>Nanomechanical recovery</topic><topic>Polymer-induced liquid-precursor</topic><topic>Polymers</topic><topic>Prepolymers</topic><topic>Quaternary Ammonium Compounds</topic><topic>Silver Compounds</topic><topic>Silver diamine fluoride</topic><topic>Therapy</topic><topic>Topical application</topic><toplevel>online_resources</toplevel><creatorcontrib>NURROHMAN, Hamid</creatorcontrib><creatorcontrib>HABELITZ, Stefan</creatorcontrib><creatorcontrib>SAEKI, Kuniko</creatorcontrib><creatorcontrib>SADR, Alireza</creatorcontrib><creatorcontrib>GOWER, Laurie B.</creatorcontrib><creatorcontrib>PAZDERNIK, Vanessa</creatorcontrib><creatorcontrib>TAGAMI, Junji</creatorcontrib><creatorcontrib>MARSHALL, Sally J.</creatorcontrib><creatorcontrib>MARSHALL, Grayson W.</creatorcontrib><creatorcontrib>Department of Preventive and Restorative Dental Sciences</creatorcontrib><creatorcontrib>Biomimetics Biomaterials Biophotonics & Technology Laboratory</creatorcontrib><creatorcontrib>Department of Restorative Dentistry</creatorcontrib><creatorcontrib>University of Florida</creatorcontrib><creatorcontrib>Graduate School of Medical and Dental Sciences</creatorcontrib><creatorcontrib>Missouri School of Dentistry and Oral Health</creatorcontrib><creatorcontrib>Materials Science and Engineering Department</creatorcontrib><creatorcontrib>Department of Cariology and Operative Dentistry</creatorcontrib><creatorcontrib>Tokyo Medical and Dental University</creatorcontrib><creatorcontrib>A. 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Still University</creatorcontrib><creatorcontrib>Department of Research Support</creatorcontrib><creatorcontrib>University of California San Francisco</creatorcontrib><creatorcontrib>University of Washington School of Dentistry</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Dental Materials Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NURROHMAN, Hamid</au><au>HABELITZ, Stefan</au><au>SAEKI, Kuniko</au><au>SADR, Alireza</au><au>GOWER, Laurie B.</au><au>PAZDERNIK, Vanessa</au><au>TAGAMI, Junji</au><au>MARSHALL, Sally J.</au><au>MARSHALL, Grayson W.</au><aucorp>Department of Preventive and Restorative Dental Sciences</aucorp><aucorp>Biomimetics Biomaterials Biophotonics & Technology Laboratory</aucorp><aucorp>Department of Restorative Dentistry</aucorp><aucorp>University of Florida</aucorp><aucorp>Graduate School of Medical and Dental Sciences</aucorp><aucorp>Missouri School of Dentistry and Oral Health</aucorp><aucorp>Materials Science and Engineering Department</aucorp><aucorp>Department of Cariology and Operative Dentistry</aucorp><aucorp>Tokyo Medical and Dental University</aucorp><aucorp>A. T. Still University</aucorp><aucorp>Department of Research Support</aucorp><aucorp>University of California San Francisco</aucorp><aucorp>University of Washington School of Dentistry</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhanced silver diamine fluoride therapy using the PILP method —A nanoindentation study</atitle><jtitle>Dental Materials Journal</jtitle><addtitle>Dent. Mater. J.</addtitle><date>2020-11-27</date><risdate>2020</risdate><volume>39</volume><issue>6</issue><spage>1009</spage><epage>1015</epage><pages>1009-1015</pages><issn>0287-4547</issn><eissn>1881-1361</eissn><abstract>The aim of this study was to evaluate the feasibility of applying the polymer-induced liquid-precursor (PILP) method to enhance silver diamine fluoride (SDF) therapy. One hundred forty micrometer deep artificial caries lesions were treated with (A) 38% SDF solution and (B) 38% SDF containing poly-L-aspartic acid (pASP). Changes in the nanomechanical profile across the lesion were evaluated. Hydrated artificial lesions had a low reduced elastic modulus (0.3 GPa) and nanohardness (0.02 GPa) region extending about 100 μm into the lesion, with a gradual linear increase to about 168 μm where the values plateaued to around 18 GPa/1.0 GPa. Topical application of SDF resulted in significantly recovered properties (p<0.001). SDF containing pASP resulted in greater nanomechanical properties compared to SDF alone, showing similar sloped regions up to 96 μm, then SDF alone dropped while SDF containing pASP continued at a modest slope until reaching normal at 144 μm. This nanoindentation study shows enhanced SDF therapy using the PILP method.</abstract><cop>Japan</cop><pub>The Japanese Society for Dental Materials and Devices</pub><pmid>32624525</pmid><doi>10.4012/dmj.2019-273</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; EZB-FREE-00999 freely available EZB journals |
| subjects | Artificial caries dentin lesion Aspartic acid Caries arrest Cariostatic Agents Dental caries Dental Caries - prevention & control Dentin Diamines Fluoride treatments Fluorides Fluorides, Topical Humans Lesions Mechanical properties Modulus of elasticity Nanohardness Nanoindentation Nanomechanical recovery Polymer-induced liquid-precursor Polymers Prepolymers Quaternary Ammonium Compounds Silver Compounds Silver diamine fluoride Therapy Topical application |
| title | Enhanced silver diamine fluoride therapy using the PILP method —A nanoindentation study |
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