Targeting the IL-17 Receptor Using Liposomal Spherical Nucleic Acids as Topical Therapy for Psoriasis

The activation of T helper 17 signaling plays a critical role in psoriasis pathogenesis, and systemically-administered IL-17 inhibitors are highly effective therapy for moderate-to-severe disease. We generated topically-delivered gene-regulating nanoconstructs, comprised of spherically-arrayed antis...

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Veröffentlicht in:	Journal of investigative dermatology 2020-02, Vol.140 (2), p.435-444.e4
Hauptverfasser:	Liu, Haoming, Kang, Richard S., Bagnowski, Katherine, Yu, Jeong Min, Radecki, Sara, Daniel, Weston L., Anderson, Bart R., Nallagatla, Subbarao, Schook, Andrew, Agarwal, Rishika, Giljohann, David A., Paller, Amy S.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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