Challenges of the current precision medicine approach for pancreatic cancer: A single institution experience between 2013 and 2017

Recent research on genomic profiling of pancreatic ductal adenocarcinoma (PDAC) has identified many potentially actionable alterations. However, the feasibility of using genomic profiling to guide routine clinical decision making for PDAC patients remains unclear. We retrospectively reviewed PDAC pa...

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Veröffentlicht in:	Cancer letters 2021-01, Vol.497, p.221-228
Hauptverfasser:	Ding, Ding, Javed, Ammar A., Cunningham, Dea, Teinor, Jonathan, Wright, Michael, Javed, Zunaira N., Wilt, Cara, Parish, Lindsay, Hodgin, Mary, Ryan, Amy, Judkins, Carol, McIntyre, Keith, Klein, Rachel, Azad, Nilo, Lee, Valerie, Donehower, Ross, De Jesus-Acosta, Ana, Murphy, Adrian, Le, Dung T., Shin, Eun Ji, Lennon, Anne Marie, Khashab, Mouen, Singh, Vikesh, Klein, Alison P., Roberts, Nicholas J., Hacker-Prietz, Amy, Manos, Lindsey, Walsh, Christi, Groshek, Lara, Brown, Caitlin, Yuan, Chunhui, Blair, Alex B., Groot, Vincent, Gemenetzis, Georgios, Yu, Jun, Weiss, Matthew J., Burkhart, Richard A., Burns, William R., He, Jin, Cameron, John L., Narang, Amol, Zaheer, Atif, Fishman, Elliot K., Thompson, Elizabeth D., Anders, Robert, Hruban, Ralph H., Jaffee, Elizabeth, Wolfgang, Christopher L., Zheng, Lei, Laheru, Daniel A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actionable alteration Adenocarcinoma Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomarkers, Tumor - genetics Biopsy Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - secondary Carcinoma, Pancreatic Ductal - therapy Clinical decision making Clinical genomic testing Clinical medicine Clinical trials Combined Modality Therapy Decision making FDA approval Feasibility Studies Female Follow-Up Studies Genomes High-Throughput Nucleotide Sequencing Humans Lymphatic Metastasis Male Matched therapy Medicine Metastasis Middle Aged Molecular Targeted Therapy - standards Mutation Next-generation sequencing Pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Pancreatic Neoplasms - therapy Pancreaticoduodenectomy Patients Precision Medicine Prognosis Retrospective Studies Surgery Survival analysis Time Factors Tumors
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