Acute kidney injury in hospitalized COVID-19 patients
Background Acute kidney injury (AKI) in COVID-19 patients is associated with poor prognosis. However, the incidence, risk factors and potential outcomes of AKI in hospitalized patients are not well studied. Materials and methods This is a retrospective cohort study conducted in two major university...
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| Veröffentlicht in: | International urology and nephrology 2022-05, Vol.54 (5), p.1097-1104 |
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| creator | Kanbay, Mehmet Medetalibeyoglu, Alpay Kanbay, Asiye Cevik, Enes Tanriover, Cem Baygul, Arzu Şenkal, Naci Konyaoglu, Hilal Akpinar, Timur S. Kose, Murat Covic, Adrian Tukek, Tufan |
| description | Background
Acute kidney injury (AKI) in COVID-19 patients is associated with poor prognosis. However, the incidence, risk factors and potential outcomes of AKI in hospitalized patients are not well studied.
Materials and methods
This is a retrospective cohort study conducted in two major university hospitals. Electronic health records of the patients, 18 years or older, hospitalized between 13 April and 1 June 2020 with confirmed COVID-19 were reviewed. We described the incidence and the risk factors for AKI development in COVID-19 patients. Furthermore, we investigated the effects of AKI on the length of hospital and intensive care unit (ICU) stay, the admission rates to ICU, the percentage of patients with cytokine storm and in-hospital mortality rate.
Results
Among 770 hospitalized patients included in this study, 92 (11.9%) patients developed AKI. The length of hospitalized days (16 vs 9.9,
p
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| doi_str_mv | 10.1007/s11255-021-02972-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8374419</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2649423214</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-15cc6e56960916b2944f38db73d8ffa8cb1829b12e63fd9ffa3a73e093ddd2d73</originalsourceid><addsrcrecordid>eNp9kclOwzAQhi0EomwvwAFF4sIl4DW2L0iobJWQegGulhM74JImwU5Qy9NjCJTlwMEaa-abf2b0A7CP4DGCkJ8EhDBjKcQoPslxulgDW4hxkmIm6PqP_whshzCDEEoB4SYYEUoRZIJvAXZW9J1Nnpyp7TJx9az37yF5bELrOl25V2uS8fR-cp4imbS6c7buwi7YKHUV7N5n3AF3lxe34-v0Zno1GZ_dpAXltEsRK4rMskxmUKIsx5LSkgiTc2JEWWpR5EhgmSNsM1IaGVNEc2KhJMYYbDjZAaeDbtvnc2uKONvrSrXezbVfqkY79btSu0f10LwoQXg8UUaBo08B3zz3NnRq7kJhq0rXtumDwizDgsTtcEQP_6Czpvd1PE_hjEqKCUY0UnigCt-E4G25WgZB9e6KGlxR0RX14YpaxKaDn2esWr5siAAZgBBL9YP137P_kX0Dpe2XzQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2649423214</pqid></control><display><type>article</type><title>Acute kidney injury in hospitalized COVID-19 patients</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Kanbay, Mehmet ; Medetalibeyoglu, Alpay ; Kanbay, Asiye ; Cevik, Enes ; Tanriover, Cem ; Baygul, Arzu ; Şenkal, Naci ; Konyaoglu, Hilal ; Akpinar, Timur S. ; Kose, Murat ; Covic, Adrian ; Tukek, Tufan</creator><creatorcontrib>Kanbay, Mehmet ; Medetalibeyoglu, Alpay ; Kanbay, Asiye ; Cevik, Enes ; Tanriover, Cem ; Baygul, Arzu ; Şenkal, Naci ; Konyaoglu, Hilal ; Akpinar, Timur S. ; Kose, Murat ; Covic, Adrian ; Tukek, Tufan</creatorcontrib><description>Background
Acute kidney injury (AKI) in COVID-19 patients is associated with poor prognosis. However, the incidence, risk factors and potential outcomes of AKI in hospitalized patients are not well studied.
Materials and methods
This is a retrospective cohort study conducted in two major university hospitals. Electronic health records of the patients, 18 years or older, hospitalized between 13 April and 1 June 2020 with confirmed COVID-19 were reviewed. We described the incidence and the risk factors for AKI development in COVID-19 patients. Furthermore, we investigated the effects of AKI on the length of hospital and intensive care unit (ICU) stay, the admission rates to ICU, the percentage of patients with cytokine storm and in-hospital mortality rate.
Results
Among 770 hospitalized patients included in this study, 92 (11.9%) patients developed AKI. The length of hospitalized days (16 vs 9.9,
p
< 0.001) and days spent in the hospital until ICU admission (3.5 vs. 2.5,
p
= 0.003) were higher in the AKI group compared to patients without AKI. In addition, ICU admission rates were also significantly higher in patients with AKI (63% vs. 20.7%,
p
< 0.001). The percentage of patients with AKI who developed cytokine storm was significantly higher than patients without AKI (25.9% vs. 14%,
p
= 0.009). Furthermore, the in-hospital mortality rate was significantly higher in patients with AKI (47.2% vs. 4.7%,
p
< 0.001).
Conclusions
AKI is common in hospitalized COVID-19 patients. Furthermore, we show that AKI increases the admission rates to ICU and in-hospital mortality. Our findings suggest that AKI should be effectively managed to prevent the adverse outcomes in COVID-19 patients.</description><identifier>ISSN: 1573-2584</identifier><identifier>ISSN: 0301-1623</identifier><identifier>EISSN: 1573-2584</identifier><identifier>DOI: 10.1007/s11255-021-02972-x</identifier><identifier>PMID: 34410587</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Acute Kidney Injury - epidemiology ; Acute Kidney Injury - etiology ; Coronaviruses ; COVID-19 ; COVID-19 - complications ; Cytokine Release Syndrome ; Cytokine storm ; Cytokines ; Electronic medical records ; Hospital Mortality ; Hospitalization ; Humans ; Intensive Care Units ; Kidneys ; Medicine ; Medicine & Public Health ; Mortality ; Nephrology ; Nephrology - Original Paper ; Patients ; Retrospective Studies ; Risk Factors ; Urology</subject><ispartof>International urology and nephrology, 2022-05, Vol.54 (5), p.1097-1104</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Nature B.V.</rights><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-15cc6e56960916b2944f38db73d8ffa8cb1829b12e63fd9ffa3a73e093ddd2d73</citedby><cites>FETCH-LOGICAL-c474t-15cc6e56960916b2944f38db73d8ffa8cb1829b12e63fd9ffa3a73e093ddd2d73</cites><orcidid>0000-0002-1297-0675</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11255-021-02972-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11255-021-02972-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34410587$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kanbay, Mehmet</creatorcontrib><creatorcontrib>Medetalibeyoglu, Alpay</creatorcontrib><creatorcontrib>Kanbay, Asiye</creatorcontrib><creatorcontrib>Cevik, Enes</creatorcontrib><creatorcontrib>Tanriover, Cem</creatorcontrib><creatorcontrib>Baygul, Arzu</creatorcontrib><creatorcontrib>Şenkal, Naci</creatorcontrib><creatorcontrib>Konyaoglu, Hilal</creatorcontrib><creatorcontrib>Akpinar, Timur S.</creatorcontrib><creatorcontrib>Kose, Murat</creatorcontrib><creatorcontrib>Covic, Adrian</creatorcontrib><creatorcontrib>Tukek, Tufan</creatorcontrib><title>Acute kidney injury in hospitalized COVID-19 patients</title><title>International urology and nephrology</title><addtitle>Int Urol Nephrol</addtitle><addtitle>Int Urol Nephrol</addtitle><description>Background
Acute kidney injury (AKI) in COVID-19 patients is associated with poor prognosis. However, the incidence, risk factors and potential outcomes of AKI in hospitalized patients are not well studied.
Materials and methods
This is a retrospective cohort study conducted in two major university hospitals. Electronic health records of the patients, 18 years or older, hospitalized between 13 April and 1 June 2020 with confirmed COVID-19 were reviewed. We described the incidence and the risk factors for AKI development in COVID-19 patients. Furthermore, we investigated the effects of AKI on the length of hospital and intensive care unit (ICU) stay, the admission rates to ICU, the percentage of patients with cytokine storm and in-hospital mortality rate.
Results
Among 770 hospitalized patients included in this study, 92 (11.9%) patients developed AKI. The length of hospitalized days (16 vs 9.9,
p
< 0.001) and days spent in the hospital until ICU admission (3.5 vs. 2.5,
p
= 0.003) were higher in the AKI group compared to patients without AKI. In addition, ICU admission rates were also significantly higher in patients with AKI (63% vs. 20.7%,
p
< 0.001). The percentage of patients with AKI who developed cytokine storm was significantly higher than patients without AKI (25.9% vs. 14%,
p
= 0.009). Furthermore, the in-hospital mortality rate was significantly higher in patients with AKI (47.2% vs. 4.7%,
p
< 0.001).
Conclusions
AKI is common in hospitalized COVID-19 patients. Furthermore, we show that AKI increases the admission rates to ICU and in-hospital mortality. Our findings suggest that AKI should be effectively managed to prevent the adverse outcomes in COVID-19 patients.</description><subject>Acute Kidney Injury - epidemiology</subject><subject>Acute Kidney Injury - etiology</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - complications</subject><subject>Cytokine Release Syndrome</subject><subject>Cytokine storm</subject><subject>Cytokines</subject><subject>Electronic medical records</subject><subject>Hospital Mortality</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Intensive Care Units</subject><subject>Kidneys</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mortality</subject><subject>Nephrology</subject><subject>Nephrology - Original Paper</subject><subject>Patients</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Urology</subject><issn>1573-2584</issn><issn>0301-1623</issn><issn>1573-2584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kclOwzAQhi0EomwvwAFF4sIl4DW2L0iobJWQegGulhM74JImwU5Qy9NjCJTlwMEaa-abf2b0A7CP4DGCkJ8EhDBjKcQoPslxulgDW4hxkmIm6PqP_whshzCDEEoB4SYYEUoRZIJvAXZW9J1Nnpyp7TJx9az37yF5bELrOl25V2uS8fR-cp4imbS6c7buwi7YKHUV7N5n3AF3lxe34-v0Zno1GZ_dpAXltEsRK4rMskxmUKIsx5LSkgiTc2JEWWpR5EhgmSNsM1IaGVNEc2KhJMYYbDjZAaeDbtvnc2uKONvrSrXezbVfqkY79btSu0f10LwoQXg8UUaBo08B3zz3NnRq7kJhq0rXtumDwizDgsTtcEQP_6Czpvd1PE_hjEqKCUY0UnigCt-E4G25WgZB9e6KGlxR0RX14YpaxKaDn2esWr5siAAZgBBL9YP137P_kX0Dpe2XzQ</recordid><startdate>20220501</startdate><enddate>20220501</enddate><creator>Kanbay, Mehmet</creator><creator>Medetalibeyoglu, Alpay</creator><creator>Kanbay, Asiye</creator><creator>Cevik, Enes</creator><creator>Tanriover, Cem</creator><creator>Baygul, Arzu</creator><creator>Şenkal, Naci</creator><creator>Konyaoglu, Hilal</creator><creator>Akpinar, Timur S.</creator><creator>Kose, Murat</creator><creator>Covic, Adrian</creator><creator>Tukek, Tufan</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1297-0675</orcidid></search><sort><creationdate>20220501</creationdate><title>Acute kidney injury in hospitalized COVID-19 patients</title><author>Kanbay, Mehmet ; Medetalibeyoglu, Alpay ; Kanbay, Asiye ; Cevik, Enes ; Tanriover, Cem ; Baygul, Arzu ; Şenkal, Naci ; Konyaoglu, Hilal ; Akpinar, Timur S. ; Kose, Murat ; Covic, Adrian ; Tukek, Tufan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-15cc6e56960916b2944f38db73d8ffa8cb1829b12e63fd9ffa3a73e093ddd2d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acute Kidney Injury - epidemiology</topic><topic>Acute Kidney Injury - etiology</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>COVID-19 - complications</topic><topic>Cytokine Release Syndrome</topic><topic>Cytokine storm</topic><topic>Cytokines</topic><topic>Electronic medical records</topic><topic>Hospital Mortality</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Intensive Care Units</topic><topic>Kidneys</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mortality</topic><topic>Nephrology</topic><topic>Nephrology - Original Paper</topic><topic>Patients</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kanbay, Mehmet</creatorcontrib><creatorcontrib>Medetalibeyoglu, Alpay</creatorcontrib><creatorcontrib>Kanbay, Asiye</creatorcontrib><creatorcontrib>Cevik, Enes</creatorcontrib><creatorcontrib>Tanriover, Cem</creatorcontrib><creatorcontrib>Baygul, Arzu</creatorcontrib><creatorcontrib>Şenkal, Naci</creatorcontrib><creatorcontrib>Konyaoglu, Hilal</creatorcontrib><creatorcontrib>Akpinar, Timur S.</creatorcontrib><creatorcontrib>Kose, Murat</creatorcontrib><creatorcontrib>Covic, Adrian</creatorcontrib><creatorcontrib>Tukek, Tufan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International urology and nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kanbay, Mehmet</au><au>Medetalibeyoglu, Alpay</au><au>Kanbay, Asiye</au><au>Cevik, Enes</au><au>Tanriover, Cem</au><au>Baygul, Arzu</au><au>Şenkal, Naci</au><au>Konyaoglu, Hilal</au><au>Akpinar, Timur S.</au><au>Kose, Murat</au><au>Covic, Adrian</au><au>Tukek, Tufan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute kidney injury in hospitalized COVID-19 patients</atitle><jtitle>International urology and nephrology</jtitle><stitle>Int Urol Nephrol</stitle><addtitle>Int Urol Nephrol</addtitle><date>2022-05-01</date><risdate>2022</risdate><volume>54</volume><issue>5</issue><spage>1097</spage><epage>1104</epage><pages>1097-1104</pages><issn>1573-2584</issn><issn>0301-1623</issn><eissn>1573-2584</eissn><abstract>Background
Acute kidney injury (AKI) in COVID-19 patients is associated with poor prognosis. However, the incidence, risk factors and potential outcomes of AKI in hospitalized patients are not well studied.
Materials and methods
This is a retrospective cohort study conducted in two major university hospitals. Electronic health records of the patients, 18 years or older, hospitalized between 13 April and 1 June 2020 with confirmed COVID-19 were reviewed. We described the incidence and the risk factors for AKI development in COVID-19 patients. Furthermore, we investigated the effects of AKI on the length of hospital and intensive care unit (ICU) stay, the admission rates to ICU, the percentage of patients with cytokine storm and in-hospital mortality rate.
Results
Among 770 hospitalized patients included in this study, 92 (11.9%) patients developed AKI. The length of hospitalized days (16 vs 9.9,
p
< 0.001) and days spent in the hospital until ICU admission (3.5 vs. 2.5,
p
= 0.003) were higher in the AKI group compared to patients without AKI. In addition, ICU admission rates were also significantly higher in patients with AKI (63% vs. 20.7%,
p
< 0.001). The percentage of patients with AKI who developed cytokine storm was significantly higher than patients without AKI (25.9% vs. 14%,
p
= 0.009). Furthermore, the in-hospital mortality rate was significantly higher in patients with AKI (47.2% vs. 4.7%,
p
< 0.001).
Conclusions
AKI is common in hospitalized COVID-19 patients. Furthermore, we show that AKI increases the admission rates to ICU and in-hospital mortality. Our findings suggest that AKI should be effectively managed to prevent the adverse outcomes in COVID-19 patients.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>34410587</pmid><doi>10.1007/s11255-021-02972-x</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-1297-0675</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Acute Kidney Injury - epidemiology Acute Kidney Injury - etiology Coronaviruses COVID-19 COVID-19 - complications Cytokine Release Syndrome Cytokine storm Cytokines Electronic medical records Hospital Mortality Hospitalization Humans Intensive Care Units Kidneys Medicine Medicine & Public Health Mortality Nephrology Nephrology - Original Paper Patients Retrospective Studies Risk Factors Urology |
| title | Acute kidney injury in hospitalized COVID-19 patients |
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