Integrating Tumor Sequencing Into Clinical Practice for Patients With Mismatch Repair-Deficient Lynch Syndrome Spectrum Cancers

Uninformative germline genetic testing presents a challenge to clinical management for patients suspected to have Lynch syndrome, a cancer predisposition syndrome caused by germline variants in the mismatch repair (MMR) genes or EPCAM. Among a consecutive series of MMR-deficient Lynch syndrome spect...

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Veröffentlicht in:	Clinical and translational gastroenterology 2021-08, Vol.12 (8), p.e00397-e00397
Hauptverfasser:	Dixon, Katherine, Asrat, Mary-Jill, Bedard, Angela C., Binnington, Kristin, Compton, Katie, Cremin, Carol, Heidary, Nili, Lohn, Zoe, Lovick, Niki, McCullum, Mary, Mindlin, Allison, O'Loughlin, Melanie, Petersen, Tammy, Portigal-Todd, Cheryl, Scott, Jenna, St-Martin, Genevieve, Thompson, Jennifer, Turnbull, Ruth, Mung, Sze Wing, Hong, Quan, Bezeau, Marjorie, Bosdet, Ian, Tucker, Tracy, Young, Sean, Yip, Stephen, Aubertin, Gudrun, Blood, Katherine A., Nuk, Jennifer, Sun, Sophie, Schrader, Kasmintan A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Colon Colorectal cancer Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis Colorectal Neoplasms, Hereditary Nonpolyposis - genetics DNA Methylation DNA Mismatch Repair Endometrial cancer Epithelial Cell Adhesion Molecule - genetics Female Genetic disorders Germ-Line Mutation Humans Male Microsatellite Instability Middle Aged MutL Protein Homolog 1 - genetics Polymerase chain reaction Statistical analysis Surveillance Tumors
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