Clinical application value of Inhibin B alone or in combination with other hormone indicators in subfertile men with different spermatogenesis status: A study of 324 Chinese men
Background In this study, we investigated the clinical value of serum Inhibin B alone or in combination with other hormone indicators in subfertile men. Methods This is a multicenter study involving 324 men from different cities in China. Testicular volume, routine semen analysis, serum Inhibin B, a...
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| Veröffentlicht in: | Journal of clinical laboratory analysis 2021-08, Vol.35 (8), p.e23882-n/a |
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| creator | Kong, Xiangbin Ye, Zhen Chen, Yaoping Zhao, Huan Tu, Jian Meng, Tianqing Xiong, Chengliang Li, Honggang Gong, Yijun Zheng, Liang Cheng, Bangning Zhang, Zhijun Xu, Peng |
| description | Background
In this study, we investigated the clinical value of serum Inhibin B alone or in combination with other hormone indicators in subfertile men.
Methods
This is a multicenter study involving 324 men from different cities in China. Testicular volume, routine semen analysis, serum Inhibin B, anti‐Müllerian hormone (AMH), follicle‐stimulating hormone (FSH), luteinizing hormone (LH), testosterone, estradiol, and prolactin were measured. Testicular tissue samples were also analyzed in 78 of 129 patients with azoospermia to distinguish impaired spermatogenesis from obstructive azoospermia.
Results
The concentration of Inhibin B, FSH, and AMH is related to spermatogenesis. For men with impaired spermatogenesis, including mild‐to‐moderate oligozoospermia (IMO) and severe oligozoospermia (ISO), serum levels of Inhibin B and FSH are highly correlated with sperm counting. However, in patients with idiopathic moderate oligozoospermia or severe oligozoospermia, there was no significant correlation between Inhibin B (or FSH) and sperm concentration. The upper cutoff value of Inhibin B to diagnose ISO is 58.25 pg/ml with a predictive accuracy of 80.65%. To distinguish between nonobstructive azoospermia (NOA) and obstructive azoospermia (OA), the area under the curve (AUC) for AMH + Inhibin B + FSH is very similar to Inhibin B (0.943 vs. 0.941). The cutoff level of Inhibin B to diagnose nonobstructive azoospermia is 45.9 pg/ml with a positive and negative prediction accuracy of 97.70% and 85.71%, respectively.
Conclusion
In summary, Inhibin B is a promising biomarker alone or in combination with other hormone indicators for the diagnosis of testicular spermatogenesis status, helping clinical doctors to distinguish NOA from OA. |
| doi_str_mv | 10.1002/jcla.23882 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8373365</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2562283749</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4482-37726f52a6470f7173c0db7e866eb50df6403283d8d9ba1da7934d7ac1a48c373</originalsourceid><addsrcrecordid>eNp9ks1u1DAUhSMEokNhwwMgS2xQpRT_JXZYIA0RP0UjsYG15dhO45FjD3bSah6LN6zTDBWwYOXrcz8fHeveoniJ4CWCEL_dKycvMeEcPyo2CDa8xBxXj4sN5JyVHCJyVjxLaQ8h5A2qnxZnhCKOcAM3xa_WWW-VdEAeDi4Xkw0e3Eg3GxB6cOUH21kPPgDpgs9SBPmmwpjFFb210wDCNJgIhhDHBbJeL0YhpgVOc9ebOFlnwGhOvLZ91oyfQDqYOGb22niTbAJpktOc3oFtrmZ9XDIQTEE72Ny_d3hePOmlS-bF6Twvfnz6-L39Uu6-fb5qt7tSUcpxSRjDdV9hWVMGe4YYUVB3zPC6Nl0FdV9TSDAnmuumk0hL1hCqmVRIUq4II-fF-9X3MHej0SqnjdKJQ7SjjEcRpBV_d7wdxHW4ETw_JnWVDd6cDGL4OZs0idEmZZyT3oQ5CVzRqmkQquuMvv4H3Yc5-vy9TNU4x2S0ydTFSqkYUoqmfwiDoFg2QSybIO43IcOv_oz_gP4efQbQCtzm0Rz_YyW-trvtanoHeHLBgQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2562283749</pqid></control><display><type>article</type><title>Clinical application value of Inhibin B alone or in combination with other hormone indicators in subfertile men with different spermatogenesis status: A study of 324 Chinese men</title><source>MEDLINE</source><source>Wiley Online Library Open Access</source><source>DOAJ Directory of Open Access Journals</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Kong, Xiangbin ; Ye, Zhen ; Chen, Yaoping ; Zhao, Huan ; Tu, Jian ; Meng, Tianqing ; Xiong, Chengliang ; Li, Honggang ; Gong, Yijun ; Zheng, Liang ; Cheng, Bangning ; Zhang, Zhijun ; Xu, Peng</creator><creatorcontrib>Kong, Xiangbin ; Ye, Zhen ; Chen, Yaoping ; Zhao, Huan ; Tu, Jian ; Meng, Tianqing ; Xiong, Chengliang ; Li, Honggang ; Gong, Yijun ; Zheng, Liang ; Cheng, Bangning ; Zhang, Zhijun ; Xu, Peng</creatorcontrib><description>Background
In this study, we investigated the clinical value of serum Inhibin B alone or in combination with other hormone indicators in subfertile men.
Methods
This is a multicenter study involving 324 men from different cities in China. Testicular volume, routine semen analysis, serum Inhibin B, anti‐Müllerian hormone (AMH), follicle‐stimulating hormone (FSH), luteinizing hormone (LH), testosterone, estradiol, and prolactin were measured. Testicular tissue samples were also analyzed in 78 of 129 patients with azoospermia to distinguish impaired spermatogenesis from obstructive azoospermia.
Results
The concentration of Inhibin B, FSH, and AMH is related to spermatogenesis. For men with impaired spermatogenesis, including mild‐to‐moderate oligozoospermia (IMO) and severe oligozoospermia (ISO), serum levels of Inhibin B and FSH are highly correlated with sperm counting. However, in patients with idiopathic moderate oligozoospermia or severe oligozoospermia, there was no significant correlation between Inhibin B (or FSH) and sperm concentration. The upper cutoff value of Inhibin B to diagnose ISO is 58.25 pg/ml with a predictive accuracy of 80.65%. To distinguish between nonobstructive azoospermia (NOA) and obstructive azoospermia (OA), the area under the curve (AUC) for AMH + Inhibin B + FSH is very similar to Inhibin B (0.943 vs. 0.941). The cutoff level of Inhibin B to diagnose nonobstructive azoospermia is 45.9 pg/ml with a positive and negative prediction accuracy of 97.70% and 85.71%, respectively.
Conclusion
In summary, Inhibin B is a promising biomarker alone or in combination with other hormone indicators for the diagnosis of testicular spermatogenesis status, helping clinical doctors to distinguish NOA from OA.</description><identifier>ISSN: 0887-8013</identifier><identifier>EISSN: 1098-2825</identifier><identifier>DOI: 10.1002/jcla.23882</identifier><identifier>PMID: 34181290</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>17β-Estradiol ; Adult ; Anti-Mullerian Hormone - blood ; Azoospermia - blood ; biomarker ; Biopsy ; Estradiol - blood ; Ethics ; Follicle Stimulating Hormone - blood ; Follicle-stimulating hormone ; Hormones ; Hospitals ; Humans ; Infertility ; Infertility, Male - blood ; Inhibin ; Inhibin B ; Inhibins - blood ; Laboratories ; Luteinizing hormone ; Luteinizing Hormone - blood ; Male ; Middle Aged ; Oligospermia - blood ; Oligozoospermia ; Patients ; Prolactin ; Prolactin - blood ; Radiation therapy ; Reproductive health ; Serum levels ; Sperm ; Sperm Count ; Spermatogenesis ; Spermatogenesis - physiology ; Statistical analysis ; subfertile men ; Testes ; Testis - physiology ; Testosterone ; Testosterone - blood ; Ultrasonic imaging ; Young Adult</subject><ispartof>Journal of clinical laboratory analysis, 2021-08, Vol.35 (8), p.e23882-n/a</ispartof><rights>2021 The Authors. published by Wiley Periodicals LLC.</rights><rights>2021 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC.</rights><rights>2021. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4482-37726f52a6470f7173c0db7e866eb50df6403283d8d9ba1da7934d7ac1a48c373</citedby><cites>FETCH-LOGICAL-c4482-37726f52a6470f7173c0db7e866eb50df6403283d8d9ba1da7934d7ac1a48c373</cites><orcidid>0000-0002-1831-9963 ; 0000-0001-7485-7670</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373365/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373365/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34181290$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kong, Xiangbin</creatorcontrib><creatorcontrib>Ye, Zhen</creatorcontrib><creatorcontrib>Chen, Yaoping</creatorcontrib><creatorcontrib>Zhao, Huan</creatorcontrib><creatorcontrib>Tu, Jian</creatorcontrib><creatorcontrib>Meng, Tianqing</creatorcontrib><creatorcontrib>Xiong, Chengliang</creatorcontrib><creatorcontrib>Li, Honggang</creatorcontrib><creatorcontrib>Gong, Yijun</creatorcontrib><creatorcontrib>Zheng, Liang</creatorcontrib><creatorcontrib>Cheng, Bangning</creatorcontrib><creatorcontrib>Zhang, Zhijun</creatorcontrib><creatorcontrib>Xu, Peng</creatorcontrib><title>Clinical application value of Inhibin B alone or in combination with other hormone indicators in subfertile men with different spermatogenesis status: A study of 324 Chinese men</title><title>Journal of clinical laboratory analysis</title><addtitle>J Clin Lab Anal</addtitle><description>Background
In this study, we investigated the clinical value of serum Inhibin B alone or in combination with other hormone indicators in subfertile men.
Methods
This is a multicenter study involving 324 men from different cities in China. Testicular volume, routine semen analysis, serum Inhibin B, anti‐Müllerian hormone (AMH), follicle‐stimulating hormone (FSH), luteinizing hormone (LH), testosterone, estradiol, and prolactin were measured. Testicular tissue samples were also analyzed in 78 of 129 patients with azoospermia to distinguish impaired spermatogenesis from obstructive azoospermia.
Results
The concentration of Inhibin B, FSH, and AMH is related to spermatogenesis. For men with impaired spermatogenesis, including mild‐to‐moderate oligozoospermia (IMO) and severe oligozoospermia (ISO), serum levels of Inhibin B and FSH are highly correlated with sperm counting. However, in patients with idiopathic moderate oligozoospermia or severe oligozoospermia, there was no significant correlation between Inhibin B (or FSH) and sperm concentration. The upper cutoff value of Inhibin B to diagnose ISO is 58.25 pg/ml with a predictive accuracy of 80.65%. To distinguish between nonobstructive azoospermia (NOA) and obstructive azoospermia (OA), the area under the curve (AUC) for AMH + Inhibin B + FSH is very similar to Inhibin B (0.943 vs. 0.941). The cutoff level of Inhibin B to diagnose nonobstructive azoospermia is 45.9 pg/ml with a positive and negative prediction accuracy of 97.70% and 85.71%, respectively.
Conclusion
In summary, Inhibin B is a promising biomarker alone or in combination with other hormone indicators for the diagnosis of testicular spermatogenesis status, helping clinical doctors to distinguish NOA from OA.</description><subject>17β-Estradiol</subject><subject>Adult</subject><subject>Anti-Mullerian Hormone - blood</subject><subject>Azoospermia - blood</subject><subject>biomarker</subject><subject>Biopsy</subject><subject>Estradiol - blood</subject><subject>Ethics</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Follicle-stimulating hormone</subject><subject>Hormones</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infertility</subject><subject>Infertility, Male - blood</subject><subject>Inhibin</subject><subject>Inhibin B</subject><subject>Inhibins - blood</subject><subject>Laboratories</subject><subject>Luteinizing hormone</subject><subject>Luteinizing Hormone - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oligospermia - blood</subject><subject>Oligozoospermia</subject><subject>Patients</subject><subject>Prolactin</subject><subject>Prolactin - blood</subject><subject>Radiation therapy</subject><subject>Reproductive health</subject><subject>Serum levels</subject><subject>Sperm</subject><subject>Sperm Count</subject><subject>Spermatogenesis</subject><subject>Spermatogenesis - physiology</subject><subject>Statistical analysis</subject><subject>subfertile men</subject><subject>Testes</subject><subject>Testis - physiology</subject><subject>Testosterone</subject><subject>Testosterone - blood</subject><subject>Ultrasonic imaging</subject><subject>Young Adult</subject><issn>0887-8013</issn><issn>1098-2825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9ks1u1DAUhSMEokNhwwMgS2xQpRT_JXZYIA0RP0UjsYG15dhO45FjD3bSah6LN6zTDBWwYOXrcz8fHeveoniJ4CWCEL_dKycvMeEcPyo2CDa8xBxXj4sN5JyVHCJyVjxLaQ8h5A2qnxZnhCKOcAM3xa_WWW-VdEAeDi4Xkw0e3Eg3GxB6cOUH21kPPgDpgs9SBPmmwpjFFb210wDCNJgIhhDHBbJeL0YhpgVOc9ebOFlnwGhOvLZ91oyfQDqYOGb22niTbAJpktOc3oFtrmZ9XDIQTEE72Ny_d3hePOmlS-bF6Twvfnz6-L39Uu6-fb5qt7tSUcpxSRjDdV9hWVMGe4YYUVB3zPC6Nl0FdV9TSDAnmuumk0hL1hCqmVRIUq4II-fF-9X3MHej0SqnjdKJQ7SjjEcRpBV_d7wdxHW4ETw_JnWVDd6cDGL4OZs0idEmZZyT3oQ5CVzRqmkQquuMvv4H3Yc5-vy9TNU4x2S0ydTFSqkYUoqmfwiDoFg2QSybIO43IcOv_oz_gP4efQbQCtzm0Rz_YyW-trvtanoHeHLBgQ</recordid><startdate>202108</startdate><enddate>202108</enddate><creator>Kong, Xiangbin</creator><creator>Ye, Zhen</creator><creator>Chen, Yaoping</creator><creator>Zhao, Huan</creator><creator>Tu, Jian</creator><creator>Meng, Tianqing</creator><creator>Xiong, Chengliang</creator><creator>Li, Honggang</creator><creator>Gong, Yijun</creator><creator>Zheng, Liang</creator><creator>Cheng, Bangning</creator><creator>Zhang, Zhijun</creator><creator>Xu, Peng</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1831-9963</orcidid><orcidid>https://orcid.org/0000-0001-7485-7670</orcidid></search><sort><creationdate>202108</creationdate><title>Clinical application value of Inhibin B alone or in combination with other hormone indicators in subfertile men with different spermatogenesis status: A study of 324 Chinese men</title><author>Kong, Xiangbin ; Ye, Zhen ; Chen, Yaoping ; Zhao, Huan ; Tu, Jian ; Meng, Tianqing ; Xiong, Chengliang ; Li, Honggang ; Gong, Yijun ; Zheng, Liang ; Cheng, Bangning ; Zhang, Zhijun ; Xu, Peng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4482-37726f52a6470f7173c0db7e866eb50df6403283d8d9ba1da7934d7ac1a48c373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>17β-Estradiol</topic><topic>Adult</topic><topic>Anti-Mullerian Hormone - blood</topic><topic>Azoospermia - blood</topic><topic>biomarker</topic><topic>Biopsy</topic><topic>Estradiol - blood</topic><topic>Ethics</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Follicle-stimulating hormone</topic><topic>Hormones</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infertility</topic><topic>Infertility, Male - blood</topic><topic>Inhibin</topic><topic>Inhibin B</topic><topic>Inhibins - blood</topic><topic>Laboratories</topic><topic>Luteinizing hormone</topic><topic>Luteinizing Hormone - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oligospermia - blood</topic><topic>Oligozoospermia</topic><topic>Patients</topic><topic>Prolactin</topic><topic>Prolactin - blood</topic><topic>Radiation therapy</topic><topic>Reproductive health</topic><topic>Serum levels</topic><topic>Sperm</topic><topic>Sperm Count</topic><topic>Spermatogenesis</topic><topic>Spermatogenesis - physiology</topic><topic>Statistical analysis</topic><topic>subfertile men</topic><topic>Testes</topic><topic>Testis - physiology</topic><topic>Testosterone</topic><topic>Testosterone - blood</topic><topic>Ultrasonic imaging</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kong, Xiangbin</creatorcontrib><creatorcontrib>Ye, Zhen</creatorcontrib><creatorcontrib>Chen, Yaoping</creatorcontrib><creatorcontrib>Zhao, Huan</creatorcontrib><creatorcontrib>Tu, Jian</creatorcontrib><creatorcontrib>Meng, Tianqing</creatorcontrib><creatorcontrib>Xiong, Chengliang</creatorcontrib><creatorcontrib>Li, Honggang</creatorcontrib><creatorcontrib>Gong, Yijun</creatorcontrib><creatorcontrib>Zheng, Liang</creatorcontrib><creatorcontrib>Cheng, Bangning</creatorcontrib><creatorcontrib>Zhang, Zhijun</creatorcontrib><creatorcontrib>Xu, Peng</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical laboratory analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kong, Xiangbin</au><au>Ye, Zhen</au><au>Chen, Yaoping</au><au>Zhao, Huan</au><au>Tu, Jian</au><au>Meng, Tianqing</au><au>Xiong, Chengliang</au><au>Li, Honggang</au><au>Gong, Yijun</au><au>Zheng, Liang</au><au>Cheng, Bangning</au><au>Zhang, Zhijun</au><au>Xu, Peng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical application value of Inhibin B alone or in combination with other hormone indicators in subfertile men with different spermatogenesis status: A study of 324 Chinese men</atitle><jtitle>Journal of clinical laboratory analysis</jtitle><addtitle>J Clin Lab Anal</addtitle><date>2021-08</date><risdate>2021</risdate><volume>35</volume><issue>8</issue><spage>e23882</spage><epage>n/a</epage><pages>e23882-n/a</pages><issn>0887-8013</issn><eissn>1098-2825</eissn><abstract>Background
In this study, we investigated the clinical value of serum Inhibin B alone or in combination with other hormone indicators in subfertile men.
Methods
This is a multicenter study involving 324 men from different cities in China. Testicular volume, routine semen analysis, serum Inhibin B, anti‐Müllerian hormone (AMH), follicle‐stimulating hormone (FSH), luteinizing hormone (LH), testosterone, estradiol, and prolactin were measured. Testicular tissue samples were also analyzed in 78 of 129 patients with azoospermia to distinguish impaired spermatogenesis from obstructive azoospermia.
Results
The concentration of Inhibin B, FSH, and AMH is related to spermatogenesis. For men with impaired spermatogenesis, including mild‐to‐moderate oligozoospermia (IMO) and severe oligozoospermia (ISO), serum levels of Inhibin B and FSH are highly correlated with sperm counting. However, in patients with idiopathic moderate oligozoospermia or severe oligozoospermia, there was no significant correlation between Inhibin B (or FSH) and sperm concentration. The upper cutoff value of Inhibin B to diagnose ISO is 58.25 pg/ml with a predictive accuracy of 80.65%. To distinguish between nonobstructive azoospermia (NOA) and obstructive azoospermia (OA), the area under the curve (AUC) for AMH + Inhibin B + FSH is very similar to Inhibin B (0.943 vs. 0.941). The cutoff level of Inhibin B to diagnose nonobstructive azoospermia is 45.9 pg/ml with a positive and negative prediction accuracy of 97.70% and 85.71%, respectively.
Conclusion
In summary, Inhibin B is a promising biomarker alone or in combination with other hormone indicators for the diagnosis of testicular spermatogenesis status, helping clinical doctors to distinguish NOA from OA.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>34181290</pmid><doi>10.1002/jcla.23882</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-1831-9963</orcidid><orcidid>https://orcid.org/0000-0001-7485-7670</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0887-8013 |
| ispartof | Journal of clinical laboratory analysis, 2021-08, Vol.35 (8), p.e23882-n/a |
| issn | 0887-8013 1098-2825 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8373365 |
| source | MEDLINE; Wiley Online Library Open Access; DOAJ Directory of Open Access Journals; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | 17β-Estradiol Adult Anti-Mullerian Hormone - blood Azoospermia - blood biomarker Biopsy Estradiol - blood Ethics Follicle Stimulating Hormone - blood Follicle-stimulating hormone Hormones Hospitals Humans Infertility Infertility, Male - blood Inhibin Inhibin B Inhibins - blood Laboratories Luteinizing hormone Luteinizing Hormone - blood Male Middle Aged Oligospermia - blood Oligozoospermia Patients Prolactin Prolactin - blood Radiation therapy Reproductive health Serum levels Sperm Sperm Count Spermatogenesis Spermatogenesis - physiology Statistical analysis subfertile men Testes Testis - physiology Testosterone Testosterone - blood Ultrasonic imaging Young Adult |
| title | Clinical application value of Inhibin B alone or in combination with other hormone indicators in subfertile men with different spermatogenesis status: A study of 324 Chinese men |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T16%3A36%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinical%20application%20value%20of%20Inhibin%20B%20alone%20or%20in%20combination%20with%20other%20hormone%20indicators%20in%20subfertile%20men%20with%20different%20spermatogenesis%20status:%20A%20study%20of%20324%20Chinese%20men&rft.jtitle=Journal%20of%20clinical%20laboratory%20analysis&rft.au=Kong,%20Xiangbin&rft.date=2021-08&rft.volume=35&rft.issue=8&rft.spage=e23882&rft.epage=n/a&rft.pages=e23882-n/a&rft.issn=0887-8013&rft.eissn=1098-2825&rft_id=info:doi/10.1002/jcla.23882&rft_dat=%3Cproquest_pubme%3E2562283749%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2562283749&rft_id=info:pmid/34181290&rfr_iscdi=true |