Assessment of adjuvantation strategy of lipid squalene nanoparticles for enhancing the immunogenicity of a SARS-CoV-2 spike subunit protein against COVID-19

Lipid squalene nanoparticles (SQ@NPs) play a crucial role in the immunogenicity of the SARS-CoV-2 spike subunit protein against COVID-19. In a mouse model, we found that one dose of the S-protein with SQ@NPs works as well as two doses of the S-protein alone without compromising safety aspects follow...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	International journal of pharmaceutics 2021-09, Vol.607, p.121024-121024, Article 121024
Hauptverfasser:	Ho, Hui-Min, Huang, Chiung-Yi, Cheng, Yu-Jhen, Shen, Kuan-Yin, Tzeng, Tsai-Teng, Liu, Shih-Jen, Chen, Hsin-Wei, Huang, Chung-Hsiung, Huang, Ming-Hsi
Format:	Artikel
Sprache:	eng
Schlagworte:	COVID-19 vaccine Immunomodulation Lipid squalene nanoparticles Single injection Vaccine adjuvant
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!