Association between polymorphisms of genes involved in the Renin-Angiotensin-Aldosterone System and the adaptive morphological and functional responses to essential hypertension
Hypertensive cardiac remodeling is illustrated by increased left ventricular (LV) mass index values and/or relative wall thickness (RWT) values >0.42, and functionally by isolated alteration of LV diastole (abnormal relaxation). The aim of the present study was to establish differentiated models...
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| Veröffentlicht in: | Biomedical reports 2021-10, Vol.15 (4), p.80, Article 80 |
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| creator | Mocan, Oana Rădulescu, Dan Buzdugan, Elena Cozma, Angela Leucuta, Daniel Corneliu Bogdan, Sidonia Alina Procopciuc, Lucia Maria |
| description | Hypertensive cardiac remodeling is illustrated by increased left ventricular (LV) mass index values and/or relative wall thickness (RWT) values >0.42, and functionally by isolated alteration of LV diastole (abnormal relaxation). The aim of the present study was to establish differentiated models of anatomical and functional adaptation to essential hypertension (EHT), in relation to the genetic variants of genes involved in the Renin-Angiotensin-Aldosterone System (RAAS). The
-AGT,
-ACE,
-R1AngII,
-R2AngII and
-REN genotypes were determined using PCR-Restriction Fragment Length Polymorphism in 139 hypertensive subjects. The relationship between the studied RAAS gene polymorphisms with morphological and functional cardiac remodeling was assessed by multiple logistic regression analysis. Patients carrying the
,
genotypes (
-R2AngII polymorphism) had a 2.72-fold (P=0.033) increased risk of exhibiting an RWT value |
| doi_str_mv | 10.3892/br.2021.1456 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8372125</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A676106460</galeid><sourcerecordid>A676106460</sourcerecordid><originalsourceid>FETCH-LOGICAL-c479t-e274042385ba72f4b79655ab5c981ff64ab3fcbf3526c4fbf2574f1b6611e9303</originalsourceid><addsrcrecordid>eNptUk1v3CAQtapWTZTm1nOF1EsP3a0NGJtLpVXULylSpX6cEeBhl8hmXPButD-r_7DYSbdNVTgwDG_eg-EVxfOqXLNW0jcmrmlJq3XFa_GoOKcllyvJOX18ihk_Ky5TuinzkE1J6_ZpccYyREohzoufm5TQej15DMTAdAsQyIj9ccA47nwaEkFHthAgER8O2B-gywGZdkC-QPBhtQlbjxOENMd9h2mCiAHI12OOBqJDt4B1p8fJH4AsxNjj1lvdL8duH-ysn7cR0oghZbEJCaQEYfI5vTuOEBcNDM-KJ073CS7v14vi-_t3364-rq4_f_h0tbleWd7IaQW04SWnrK2NbqjjppGirrWprWwr5wTXhjlrHKupsNwZR-uGu8oIUVUgWckuird3vOPeDNDZfJWoezVGP-h4VKi9engS_E5t8aBa1tCK1png1T1BxB97SJMafLLQ9zoA7pOiteBc0nbRevkP9Ab3MTdkQUlGGaPiD2qre1A-OMy6diZVG9GIqhRczFzr_6Dy7GDwNv-M8zn_oOD1XYGNmFIEd3pjVarZZcpENbtMzS7L8Bd_9-UE_u0p9gtJktGU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2569323326</pqid></control><display><type>article</type><title>Association between polymorphisms of genes involved in the Renin-Angiotensin-Aldosterone System and the adaptive morphological and functional responses to essential hypertension</title><source>Spandidos Publications Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Mocan, Oana ; Rădulescu, Dan ; Buzdugan, Elena ; Cozma, Angela ; Leucuta, Daniel Corneliu ; Bogdan, Sidonia Alina ; Procopciuc, Lucia Maria</creator><creatorcontrib>Mocan, Oana ; Rădulescu, Dan ; Buzdugan, Elena ; Cozma, Angela ; Leucuta, Daniel Corneliu ; Bogdan, Sidonia Alina ; Procopciuc, Lucia Maria</creatorcontrib><description>Hypertensive cardiac remodeling is illustrated by increased left ventricular (LV) mass index values and/or relative wall thickness (RWT) values >0.42, and functionally by isolated alteration of LV diastole (abnormal relaxation). The aim of the present study was to establish differentiated models of anatomical and functional adaptation to essential hypertension (EHT), in relation to the genetic variants of genes involved in the Renin-Angiotensin-Aldosterone System (RAAS). The
-AGT,
-ACE,
-R1AngII,
-R2AngII and
-REN genotypes were determined using PCR-Restriction Fragment Length Polymorphism in 139 hypertensive subjects. The relationship between the studied RAAS gene polymorphisms with morphological and functional cardiac remodeling was assessed by multiple logistic regression analysis. Patients carrying the
,
genotypes (
-R2AngII polymorphism) had a 2.72-fold (P=0.033) increased risk of exhibiting an RWT value <0.42; in the multivariate model the risk was 4.02-fold higher (P=0.008). Analysis of LV diastolic dysfunction (LVDD) revealed that hypertensive patients carrying the
,
genotypes (
-AGT polymorphism) had a 2.24-fold (P=0.037) increased risk of developing LVDD and a 2.42-fold increased risk (P=0.039) after adjustment for confounders. Similarly, carriers of the
,
genotypes (
-REN) had a 2.32-fold (P=0.021) increased risk of developing LVDD, and this remained an independent risk factor based on the multivariate model (P=0.033). The results of the present study showed that no particular gene was associated with increased LV mass, but the
-R2AngII polymorphism was associated with a non-concentric type of cardiac response in hypertensive patients. Conversely, the
-AGT and
-REN polymorphisms were found to be statistically significantly associated with LVDD when assessing abnormal relaxation.</description><identifier>ISSN: 2049-9434</identifier><identifier>ISSN: 2049-9442</identifier><identifier>EISSN: 2049-9442</identifier><identifier>DOI: 10.3892/br.2021.1456</identifier><identifier>PMID: 34429966</identifier><language>eng</language><publisher>England: Spandidos Publications</publisher><subject>Aldosterone ; Angiotensin ; Body mass index ; Corticosteroids ; Diastole ; Ejection fraction ; Endocrine system ; Gene polymorphism ; Genes ; Genetic aspects ; Genetic diversity ; Genetic polymorphisms ; Genetic research ; Genotype & phenotype ; Heart ; Heart failure ; Hypertension ; Multivariate analysis ; Mutation ; Pathogenesis ; Patients ; Polymorphism ; Regression analysis ; Renin ; Restriction fragment length polymorphism ; Risk analysis ; Risk factors ; Ultrasonic imaging ; Values ; Velocity ; Ventricle</subject><ispartof>Biomedical reports, 2021-10, Vol.15 (4), p.80, Article 80</ispartof><rights>Copyright: © Mocan et al.</rights><rights>COPYRIGHT 2021 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2021</rights><rights>Copyright: © Mocan et al. 2020</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-e274042385ba72f4b79655ab5c981ff64ab3fcbf3526c4fbf2574f1b6611e9303</citedby><cites>FETCH-LOGICAL-c479t-e274042385ba72f4b79655ab5c981ff64ab3fcbf3526c4fbf2574f1b6611e9303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8372125/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8372125/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34429966$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mocan, Oana</creatorcontrib><creatorcontrib>Rădulescu, Dan</creatorcontrib><creatorcontrib>Buzdugan, Elena</creatorcontrib><creatorcontrib>Cozma, Angela</creatorcontrib><creatorcontrib>Leucuta, Daniel Corneliu</creatorcontrib><creatorcontrib>Bogdan, Sidonia Alina</creatorcontrib><creatorcontrib>Procopciuc, Lucia Maria</creatorcontrib><title>Association between polymorphisms of genes involved in the Renin-Angiotensin-Aldosterone System and the adaptive morphological and functional responses to essential hypertension</title><title>Biomedical reports</title><addtitle>Biomed Rep</addtitle><description>Hypertensive cardiac remodeling is illustrated by increased left ventricular (LV) mass index values and/or relative wall thickness (RWT) values >0.42, and functionally by isolated alteration of LV diastole (abnormal relaxation). The aim of the present study was to establish differentiated models of anatomical and functional adaptation to essential hypertension (EHT), in relation to the genetic variants of genes involved in the Renin-Angiotensin-Aldosterone System (RAAS). The
-AGT,
-ACE,
-R1AngII,
-R2AngII and
-REN genotypes were determined using PCR-Restriction Fragment Length Polymorphism in 139 hypertensive subjects. The relationship between the studied RAAS gene polymorphisms with morphological and functional cardiac remodeling was assessed by multiple logistic regression analysis. Patients carrying the
,
genotypes (
-R2AngII polymorphism) had a 2.72-fold (P=0.033) increased risk of exhibiting an RWT value <0.42; in the multivariate model the risk was 4.02-fold higher (P=0.008). Analysis of LV diastolic dysfunction (LVDD) revealed that hypertensive patients carrying the
,
genotypes (
-AGT polymorphism) had a 2.24-fold (P=0.037) increased risk of developing LVDD and a 2.42-fold increased risk (P=0.039) after adjustment for confounders. Similarly, carriers of the
,
genotypes (
-REN) had a 2.32-fold (P=0.021) increased risk of developing LVDD, and this remained an independent risk factor based on the multivariate model (P=0.033). The results of the present study showed that no particular gene was associated with increased LV mass, but the
-R2AngII polymorphism was associated with a non-concentric type of cardiac response in hypertensive patients. Conversely, the
-AGT and
-REN polymorphisms were found to be statistically significantly associated with LVDD when assessing abnormal relaxation.</description><subject>Aldosterone</subject><subject>Angiotensin</subject><subject>Body mass index</subject><subject>Corticosteroids</subject><subject>Diastole</subject><subject>Ejection fraction</subject><subject>Endocrine system</subject><subject>Gene polymorphism</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic diversity</subject><subject>Genetic polymorphisms</subject><subject>Genetic research</subject><subject>Genotype & phenotype</subject><subject>Heart</subject><subject>Heart failure</subject><subject>Hypertension</subject><subject>Multivariate analysis</subject><subject>Mutation</subject><subject>Pathogenesis</subject><subject>Patients</subject><subject>Polymorphism</subject><subject>Regression analysis</subject><subject>Renin</subject><subject>Restriction fragment length polymorphism</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Ultrasonic imaging</subject><subject>Values</subject><subject>Velocity</subject><subject>Ventricle</subject><issn>2049-9434</issn><issn>2049-9442</issn><issn>2049-9442</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptUk1v3CAQtapWTZTm1nOF1EsP3a0NGJtLpVXULylSpX6cEeBhl8hmXPButD-r_7DYSbdNVTgwDG_eg-EVxfOqXLNW0jcmrmlJq3XFa_GoOKcllyvJOX18ihk_Ky5TuinzkE1J6_ZpccYyREohzoufm5TQej15DMTAdAsQyIj9ccA47nwaEkFHthAgER8O2B-gywGZdkC-QPBhtQlbjxOENMd9h2mCiAHI12OOBqJDt4B1p8fJH4AsxNjj1lvdL8duH-ysn7cR0oghZbEJCaQEYfI5vTuOEBcNDM-KJ073CS7v14vi-_t3364-rq4_f_h0tbleWd7IaQW04SWnrK2NbqjjppGirrWprWwr5wTXhjlrHKupsNwZR-uGu8oIUVUgWckuird3vOPeDNDZfJWoezVGP-h4VKi9engS_E5t8aBa1tCK1png1T1BxB97SJMafLLQ9zoA7pOiteBc0nbRevkP9Ab3MTdkQUlGGaPiD2qre1A-OMy6diZVG9GIqhRczFzr_6Dy7GDwNv-M8zn_oOD1XYGNmFIEd3pjVarZZcpENbtMzS7L8Bd_9-UE_u0p9gtJktGU</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Mocan, Oana</creator><creator>Rădulescu, Dan</creator><creator>Buzdugan, Elena</creator><creator>Cozma, Angela</creator><creator>Leucuta, Daniel Corneliu</creator><creator>Bogdan, Sidonia Alina</creator><creator>Procopciuc, Lucia Maria</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. 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The aim of the present study was to establish differentiated models of anatomical and functional adaptation to essential hypertension (EHT), in relation to the genetic variants of genes involved in the Renin-Angiotensin-Aldosterone System (RAAS). The
-AGT,
-ACE,
-R1AngII,
-R2AngII and
-REN genotypes were determined using PCR-Restriction Fragment Length Polymorphism in 139 hypertensive subjects. The relationship between the studied RAAS gene polymorphisms with morphological and functional cardiac remodeling was assessed by multiple logistic regression analysis. Patients carrying the
,
genotypes (
-R2AngII polymorphism) had a 2.72-fold (P=0.033) increased risk of exhibiting an RWT value <0.42; in the multivariate model the risk was 4.02-fold higher (P=0.008). Analysis of LV diastolic dysfunction (LVDD) revealed that hypertensive patients carrying the
,
genotypes (
-AGT polymorphism) had a 2.24-fold (P=0.037) increased risk of developing LVDD and a 2.42-fold increased risk (P=0.039) after adjustment for confounders. Similarly, carriers of the
,
genotypes (
-REN) had a 2.32-fold (P=0.021) increased risk of developing LVDD, and this remained an independent risk factor based on the multivariate model (P=0.033). The results of the present study showed that no particular gene was associated with increased LV mass, but the
-R2AngII polymorphism was associated with a non-concentric type of cardiac response in hypertensive patients. Conversely, the
-AGT and
-REN polymorphisms were found to be statistically significantly associated with LVDD when assessing abnormal relaxation.</abstract><cop>England</cop><pub>Spandidos Publications</pub><pmid>34429966</pmid><doi>10.3892/br.2021.1456</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Biomedical reports, 2021-10, Vol.15 (4), p.80, Article 80 |
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| source | Spandidos Publications Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Aldosterone Angiotensin Body mass index Corticosteroids Diastole Ejection fraction Endocrine system Gene polymorphism Genes Genetic aspects Genetic diversity Genetic polymorphisms Genetic research Genotype & phenotype Heart Heart failure Hypertension Multivariate analysis Mutation Pathogenesis Patients Polymorphism Regression analysis Renin Restriction fragment length polymorphism Risk analysis Risk factors Ultrasonic imaging Values Velocity Ventricle |
| title | Association between polymorphisms of genes involved in the Renin-Angiotensin-Aldosterone System and the adaptive morphological and functional responses to essential hypertension |
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