Determining the immunohistochemical expression of GLUT1 in renal cell carcinoma using the HSCORE method
The aim of the present study was to compare the immunohistochemical expression of glucose transporter 1 (GLUT1) between the most common histological types of renal cell carcinoma (RCC), and to determine whether a correlation between GLUT1 expression and nuclear grade or tumor size exists. A total of...
Gespeichert in:
| Veröffentlicht in: | Biomedical reports 2021-10, Vol.15 (4), p.1-79, Article 79 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 79 |
|---|---|
| container_issue | 4 |
| container_start_page | 1 |
| container_title | Biomedical reports |
| container_volume | 15 |
| creator | Ogorevc, Marin Strikic, Ante Tomas, Sandra Zekic |
| description | The aim of the present study was to compare the immunohistochemical expression of glucose transporter 1 (GLUT1) between the most common histological types of renal cell carcinoma (RCC), and to determine whether a correlation between GLUT1 expression and nuclear grade or tumor size exists. A total of 19 RCC samples were selected for the study, consisting of 8 clear cell (cc)RCC and 11 non-ccRCC tissues. Immunohistochemistry for GLUT1 was performed on formalin-fixed and paraffin-embedded sections using GLUT1 antibodies. All data analyses were performed using the MedCalc software. There was a higher immunohistochemical expression of GLUT1 in the ccRCC group compared with the non-cc group, but there was no difference in GLUT1 expression between groups of RCCs with differing nuclear grades. No significant correlation between GLUT1 expression and tumor size was found. The higher immunohistochemical expression of GLUT1 in ccRCC may be a contributing factor to the clinical characteristics and behavior of that group of carcinomas. These results suggest that GLUT1 expression cannot be used as a prognostic factor for RCC, but it may be used as a predictive factor in the future. |
| doi_str_mv | 10.3892/br.2021.1455 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8372117</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A676106459</galeid><sourcerecordid>A676106459</sourcerecordid><originalsourceid>FETCH-LOGICAL-c456t-e27a9ce07b0e28be551754bc825f72ed1e213f6db8dc9ba5651a7ad7e99649c33</originalsourceid><addsrcrecordid>eNptkl1rHCEUhqW0NCHNXX7AQG960d36OY43hbBNk8BCIB_X4jhndgyjbnWmtP--Tr5KShU84nnOK68ehE4IXrNG0S9tWlNMyZpwId6gQ4q5WinO6duXPeMH6Djne1yGkpiK5j06YAVRqhaHaPcNJkjeBRd21TRA5byfQxxcnqIdwDtrxgp-7RPk7GKoYl-db-9uSeVClSCUpIWxLCZZF6I31ZyflS5uNlfXZ5WHaYjdB_SuN2OG46d4hO6-n91uLlbbq_PLzel2ZbmopxVQaZQFLFsMtGlBCCIFb21DRS8pdAQoYX3dtU1nVWtELYiRppNQ3HBlGTtCXx9193ProbMQpmRGvU_Om_RbR-P060xwg97Fn7phkhIii8CnJ4EUf8yQJ-1dXjyaAHHOmoqac0UFUQX9-A96H-dU3uSBUowyLMlfamdG0C70sdxrF1F9Wsua4JqLRWv9H6rMbvmDGKB35fxVwefHAptizgn6F48E66U3dJv00ht66Q32Bw40qdU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2569323071</pqid></control><display><type>article</type><title>Determining the immunohistochemical expression of GLUT1 in renal cell carcinoma using the HSCORE method</title><source>Spandidos Publications Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Ogorevc, Marin ; Strikic, Ante ; Tomas, Sandra Zekic</creator><creatorcontrib>Ogorevc, Marin ; Strikic, Ante ; Tomas, Sandra Zekic</creatorcontrib><description>The aim of the present study was to compare the immunohistochemical expression of glucose transporter 1 (GLUT1) between the most common histological types of renal cell carcinoma (RCC), and to determine whether a correlation between GLUT1 expression and nuclear grade or tumor size exists. A total of 19 RCC samples were selected for the study, consisting of 8 clear cell (cc)RCC and 11 non-ccRCC tissues. Immunohistochemistry for GLUT1 was performed on formalin-fixed and paraffin-embedded sections using GLUT1 antibodies. All data analyses were performed using the MedCalc software. There was a higher immunohistochemical expression of GLUT1 in the ccRCC group compared with the non-cc group, but there was no difference in GLUT1 expression between groups of RCCs with differing nuclear grades. No significant correlation between GLUT1 expression and tumor size was found. The higher immunohistochemical expression of GLUT1 in ccRCC may be a contributing factor to the clinical characteristics and behavior of that group of carcinomas. These results suggest that GLUT1 expression cannot be used as a prognostic factor for RCC, but it may be used as a predictive factor in the future.</description><identifier>ISSN: 2049-9434</identifier><identifier>EISSN: 2049-9442</identifier><identifier>DOI: 10.3892/br.2021.1455</identifier><identifier>PMID: 34429965</identifier><language>eng</language><publisher>Athens: Spandidos Publications</publisher><subject>Age ; Antibodies ; Archives & records ; Carcinoma, Renal cell ; Comparative analysis ; Consent ; Dextrose ; Formaldehyde ; Glucose ; Glucose transporter ; Hypoxia ; Immunohistochemistry ; Kidney cancer ; Medical prognosis ; Metabolism ; Methods ; Ovarian cancer ; Paraffin ; Paraffins ; Proteins ; Renal cell carcinoma ; Software ; Tumors</subject><ispartof>Biomedical reports, 2021-10, Vol.15 (4), p.1-79, Article 79</ispartof><rights>COPYRIGHT 2021 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2021</rights><rights>Copyright © 2020, Spandidos Publications 2020</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-e27a9ce07b0e28be551754bc825f72ed1e213f6db8dc9ba5651a7ad7e99649c33</citedby><cites>FETCH-LOGICAL-c456t-e27a9ce07b0e28be551754bc825f72ed1e213f6db8dc9ba5651a7ad7e99649c33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8372117/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8372117/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Ogorevc, Marin</creatorcontrib><creatorcontrib>Strikic, Ante</creatorcontrib><creatorcontrib>Tomas, Sandra Zekic</creatorcontrib><title>Determining the immunohistochemical expression of GLUT1 in renal cell carcinoma using the HSCORE method</title><title>Biomedical reports</title><description>The aim of the present study was to compare the immunohistochemical expression of glucose transporter 1 (GLUT1) between the most common histological types of renal cell carcinoma (RCC), and to determine whether a correlation between GLUT1 expression and nuclear grade or tumor size exists. A total of 19 RCC samples were selected for the study, consisting of 8 clear cell (cc)RCC and 11 non-ccRCC tissues. Immunohistochemistry for GLUT1 was performed on formalin-fixed and paraffin-embedded sections using GLUT1 antibodies. All data analyses were performed using the MedCalc software. There was a higher immunohistochemical expression of GLUT1 in the ccRCC group compared with the non-cc group, but there was no difference in GLUT1 expression between groups of RCCs with differing nuclear grades. No significant correlation between GLUT1 expression and tumor size was found. The higher immunohistochemical expression of GLUT1 in ccRCC may be a contributing factor to the clinical characteristics and behavior of that group of carcinomas. These results suggest that GLUT1 expression cannot be used as a prognostic factor for RCC, but it may be used as a predictive factor in the future.</description><subject>Age</subject><subject>Antibodies</subject><subject>Archives & records</subject><subject>Carcinoma, Renal cell</subject><subject>Comparative analysis</subject><subject>Consent</subject><subject>Dextrose</subject><subject>Formaldehyde</subject><subject>Glucose</subject><subject>Glucose transporter</subject><subject>Hypoxia</subject><subject>Immunohistochemistry</subject><subject>Kidney cancer</subject><subject>Medical prognosis</subject><subject>Metabolism</subject><subject>Methods</subject><subject>Ovarian cancer</subject><subject>Paraffin</subject><subject>Paraffins</subject><subject>Proteins</subject><subject>Renal cell carcinoma</subject><subject>Software</subject><subject>Tumors</subject><issn>2049-9434</issn><issn>2049-9442</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptkl1rHCEUhqW0NCHNXX7AQG960d36OY43hbBNk8BCIB_X4jhndgyjbnWmtP--Tr5KShU84nnOK68ehE4IXrNG0S9tWlNMyZpwId6gQ4q5WinO6duXPeMH6Djne1yGkpiK5j06YAVRqhaHaPcNJkjeBRd21TRA5byfQxxcnqIdwDtrxgp-7RPk7GKoYl-db-9uSeVClSCUpIWxLCZZF6I31ZyflS5uNlfXZ5WHaYjdB_SuN2OG46d4hO6-n91uLlbbq_PLzel2ZbmopxVQaZQFLFsMtGlBCCIFb21DRS8pdAQoYX3dtU1nVWtELYiRppNQ3HBlGTtCXx9193ProbMQpmRGvU_Om_RbR-P060xwg97Fn7phkhIii8CnJ4EUf8yQJ-1dXjyaAHHOmoqac0UFUQX9-A96H-dU3uSBUowyLMlfamdG0C70sdxrF1F9Wsua4JqLRWv9H6rMbvmDGKB35fxVwefHAptizgn6F48E66U3dJv00ht66Q32Bw40qdU</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Ogorevc, Marin</creator><creator>Strikic, Ante</creator><creator>Tomas, Sandra Zekic</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. Spandidos</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20211001</creationdate><title>Determining the immunohistochemical expression of GLUT1 in renal cell carcinoma using the HSCORE method</title><author>Ogorevc, Marin ; Strikic, Ante ; Tomas, Sandra Zekic</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-e27a9ce07b0e28be551754bc825f72ed1e213f6db8dc9ba5651a7ad7e99649c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Age</topic><topic>Antibodies</topic><topic>Archives & records</topic><topic>Carcinoma, Renal cell</topic><topic>Comparative analysis</topic><topic>Consent</topic><topic>Dextrose</topic><topic>Formaldehyde</topic><topic>Glucose</topic><topic>Glucose transporter</topic><topic>Hypoxia</topic><topic>Immunohistochemistry</topic><topic>Kidney cancer</topic><topic>Medical prognosis</topic><topic>Metabolism</topic><topic>Methods</topic><topic>Ovarian cancer</topic><topic>Paraffin</topic><topic>Paraffins</topic><topic>Proteins</topic><topic>Renal cell carcinoma</topic><topic>Software</topic><topic>Tumors</topic><toplevel>online_resources</toplevel><creatorcontrib>Ogorevc, Marin</creatorcontrib><creatorcontrib>Strikic, Ante</creatorcontrib><creatorcontrib>Tomas, Sandra Zekic</creatorcontrib><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biomedical reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ogorevc, Marin</au><au>Strikic, Ante</au><au>Tomas, Sandra Zekic</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determining the immunohistochemical expression of GLUT1 in renal cell carcinoma using the HSCORE method</atitle><jtitle>Biomedical reports</jtitle><date>2021-10-01</date><risdate>2021</risdate><volume>15</volume><issue>4</issue><spage>1</spage><epage>79</epage><pages>1-79</pages><artnum>79</artnum><issn>2049-9434</issn><eissn>2049-9442</eissn><abstract>The aim of the present study was to compare the immunohistochemical expression of glucose transporter 1 (GLUT1) between the most common histological types of renal cell carcinoma (RCC), and to determine whether a correlation between GLUT1 expression and nuclear grade or tumor size exists. A total of 19 RCC samples were selected for the study, consisting of 8 clear cell (cc)RCC and 11 non-ccRCC tissues. Immunohistochemistry for GLUT1 was performed on formalin-fixed and paraffin-embedded sections using GLUT1 antibodies. All data analyses were performed using the MedCalc software. There was a higher immunohistochemical expression of GLUT1 in the ccRCC group compared with the non-cc group, but there was no difference in GLUT1 expression between groups of RCCs with differing nuclear grades. No significant correlation between GLUT1 expression and tumor size was found. The higher immunohistochemical expression of GLUT1 in ccRCC may be a contributing factor to the clinical characteristics and behavior of that group of carcinomas. These results suggest that GLUT1 expression cannot be used as a prognostic factor for RCC, but it may be used as a predictive factor in the future.</abstract><cop>Athens</cop><pub>Spandidos Publications</pub><pmid>34429965</pmid><doi>10.3892/br.2021.1455</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2049-9434 |
| ispartof | Biomedical reports, 2021-10, Vol.15 (4), p.1-79, Article 79 |
| issn | 2049-9434 2049-9442 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8372117 |
| source | Spandidos Publications Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Age Antibodies Archives & records Carcinoma, Renal cell Comparative analysis Consent Dextrose Formaldehyde Glucose Glucose transporter Hypoxia Immunohistochemistry Kidney cancer Medical prognosis Metabolism Methods Ovarian cancer Paraffin Paraffins Proteins Renal cell carcinoma Software Tumors |
| title | Determining the immunohistochemical expression of GLUT1 in renal cell carcinoma using the HSCORE method |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T20%3A21%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Determining%20the%20immunohistochemical%20expression%20of%20GLUT1%20in%20renal%20cell%20carcinoma%20using%20the%20HSCORE%20method&rft.jtitle=Biomedical%20reports&rft.au=Ogorevc,%20Marin&rft.date=2021-10-01&rft.volume=15&rft.issue=4&rft.spage=1&rft.epage=79&rft.pages=1-79&rft.artnum=79&rft.issn=2049-9434&rft.eissn=2049-9442&rft_id=info:doi/10.3892/br.2021.1455&rft_dat=%3Cgale_pubme%3EA676106459%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2569323071&rft_id=info:pmid/34429965&rft_galeid=A676106459&rfr_iscdi=true |