Histone deacetylase 1 facilitates aerobic glycolysis and growth of endometrial cancer
The deregulation of histone deacetylase 1 (HDAC1) is reportedly involved in the progression of several cancer types. However, its function in endometrial cancer remains unknown. The aim of the present study was to clarify the role of HDAC1 in aerobic glycolysis and the progression of endometrial can...
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| Veröffentlicht in: | Oncology letters 2021-10, Vol.22 (4), p.1, Article 721 |
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| creator | Wu, Qiongwei Zhang, Wenying Liu, Yu Huang, Yuhua Wu, Huiheng Ma, Chengbin |
| description | The deregulation of histone deacetylase 1 (HDAC1) is reportedly involved in the progression of several cancer types. However, its function in endometrial cancer remains unknown. The aim of the present study was to clarify the role of HDAC1 in aerobic glycolysis and the progression of endometrial cancer. Lentiviral vector transfection was used to up- and downregulate HDAC1 expression in HEC-1-A endometrial cancer cells. The effects of HDAC1 on cellular proliferation, apoptosis, migration, invasiveness and tumorigenesis were determined by CCK-8, flow cytometry, wound-healing, transwell chamber and in vivo tumor formation experiments, respectively. HDAC1 level was significantly increased in endometrial cancer tissues and cells, and its high expression was associated with advanced clinicopathological progression. HEC-1-A cell proliferation, invasiveness, migration and tumorigenesis were enhanced, and apoptosis was inhibited when HDAC1 was overexpressed. Moreover, upregulation of HDAC1 significantly promoted the epithelial-mesenchymal transition of HEC-1-A cells, and increased glucose consumption, lactate secretion and ATP levels. Collectively, the present study revealed that HDAC1 promoted the aerobic glycolysis and progression of endometrial cancer, which may provide a potential target for endometrial cancer treatment. Key words: histone deacetylase 1, growth, epithelial-mesenchymal transition, aerobic glycolysis, migration |
| doi_str_mv | 10.3892/ol.2021.12982 |
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However, its function in endometrial cancer remains unknown. The aim of the present study was to clarify the role of HDAC1 in aerobic glycolysis and the progression of endometrial cancer. Lentiviral vector transfection was used to up- and downregulate HDAC1 expression in HEC-1-A endometrial cancer cells. The effects of HDAC1 on cellular proliferation, apoptosis, migration, invasiveness and tumorigenesis were determined by CCK-8, flow cytometry, wound-healing, transwell chamber and in vivo tumor formation experiments, respectively. HDAC1 level was significantly increased in endometrial cancer tissues and cells, and its high expression was associated with advanced clinicopathological progression. HEC-1-A cell proliferation, invasiveness, migration and tumorigenesis were enhanced, and apoptosis was inhibited when HDAC1 was overexpressed. Moreover, upregulation of HDAC1 significantly promoted the epithelial-mesenchymal transition of HEC-1-A cells, and increased glucose consumption, lactate secretion and ATP levels. Collectively, the present study revealed that HDAC1 promoted the aerobic glycolysis and progression of endometrial cancer, which may provide a potential target for endometrial cancer treatment. Key words: histone deacetylase 1, growth, epithelial-mesenchymal transition, aerobic glycolysis, migration</description><identifier>ISSN: 1792-1074</identifier><identifier>EISSN: 1792-1082</identifier><identifier>DOI: 10.3892/ol.2021.12982</identifier><identifier>PMID: 34429761</identifier><language>eng</language><publisher>Athens: Spandidos Publications</publisher><subject>Apoptosis ; Cancer ; Cell culture ; Endometrial cancer ; Ethylenediaminetetraacetic acid ; Flow cytometry ; Glucose metabolism ; Growth ; Infection ; Instrument industry ; Kinases ; Laboratories ; Medical prognosis ; Metastasis ; Ovarian cancer ; Patients ; Protein expression ; Proteins ; Romidepsin ; Scientific equipment and supplies industry ; Sodium ; Surgery</subject><ispartof>Oncology letters, 2021-10, Vol.22 (4), p.1, Article 721</ispartof><rights>COPYRIGHT 2021 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2021</rights><rights>Copyright: © Wu et al. 2021</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-9424f520f455b106671299819b264976b579b9abbbd98976eef42ad1cb609d643</citedby><cites>FETCH-LOGICAL-c490t-9424f520f455b106671299819b264976b579b9abbbd98976eef42ad1cb609d643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371952/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371952/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Wu, Qiongwei</creatorcontrib><creatorcontrib>Zhang, Wenying</creatorcontrib><creatorcontrib>Liu, Yu</creatorcontrib><creatorcontrib>Huang, Yuhua</creatorcontrib><creatorcontrib>Wu, Huiheng</creatorcontrib><creatorcontrib>Ma, Chengbin</creatorcontrib><title>Histone deacetylase 1 facilitates aerobic glycolysis and growth of endometrial cancer</title><title>Oncology letters</title><description>The deregulation of histone deacetylase 1 (HDAC1) is reportedly involved in the progression of several cancer types. However, its function in endometrial cancer remains unknown. The aim of the present study was to clarify the role of HDAC1 in aerobic glycolysis and the progression of endometrial cancer. Lentiviral vector transfection was used to up- and downregulate HDAC1 expression in HEC-1-A endometrial cancer cells. The effects of HDAC1 on cellular proliferation, apoptosis, migration, invasiveness and tumorigenesis were determined by CCK-8, flow cytometry, wound-healing, transwell chamber and in vivo tumor formation experiments, respectively. HDAC1 level was significantly increased in endometrial cancer tissues and cells, and its high expression was associated with advanced clinicopathological progression. HEC-1-A cell proliferation, invasiveness, migration and tumorigenesis were enhanced, and apoptosis was inhibited when HDAC1 was overexpressed. Moreover, upregulation of HDAC1 significantly promoted the epithelial-mesenchymal transition of HEC-1-A cells, and increased glucose consumption, lactate secretion and ATP levels. Collectively, the present study revealed that HDAC1 promoted the aerobic glycolysis and progression of endometrial cancer, which may provide a potential target for endometrial cancer treatment. Key words: histone deacetylase 1, growth, epithelial-mesenchymal transition, aerobic glycolysis, migration</description><subject>Apoptosis</subject><subject>Cancer</subject><subject>Cell culture</subject><subject>Endometrial cancer</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Flow cytometry</subject><subject>Glucose metabolism</subject><subject>Growth</subject><subject>Infection</subject><subject>Instrument industry</subject><subject>Kinases</subject><subject>Laboratories</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Ovarian cancer</subject><subject>Patients</subject><subject>Protein expression</subject><subject>Proteins</subject><subject>Romidepsin</subject><subject>Scientific equipment and supplies industry</subject><subject>Sodium</subject><subject>Surgery</subject><issn>1792-1074</issn><issn>1792-1082</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptkkFrHCEUx6U0NCHJMfeBQm-zUcdx9FIIoW0CgV7aXEWd567B0VTdlv02_Sz9ZHWbkHahevD5_L0_78kfoQuCV4OQ9DKFFcWUrAiVgr5CJ2SStCdY0Ncv8cSO0XkpD7itkRMh-Bt0PDBG5cTJCbq_8aWmCN0M2kLdBV3g10_SOW198FVXKJ2GnIy33TrsbAq74lsqzt06px910yXXQZzTAjV7HTqro4V8ho6cDgXOn89T9PXjhy_XN_3d50-311d3vWUS114yytxIsWPjaAjmfGqTSEGkoZy1Bs04SSO1MWaWot0BHKN6JtZwLGfOhlP0_kn3cWsWmC3EmnVQj9kvOu9U0l4dvkS_Uev0XYlhInKkTeDts0BO37ZQqnpI2xxbz4qOXMo9NP2l1jqA8tGlJmYXX6y64pPAlJJhT63-Q7U9w-Jt-2TnW_6g4N0_BRvQoW5KCtvqUyyHYP8E2pxKyeBeJiRY7Z2gUlB7J6g_Thh-A0SOo7I</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Wu, Qiongwei</creator><creator>Zhang, Wenying</creator><creator>Liu, Yu</creator><creator>Huang, Yuhua</creator><creator>Wu, Huiheng</creator><creator>Ma, Chengbin</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. 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However, its function in endometrial cancer remains unknown. The aim of the present study was to clarify the role of HDAC1 in aerobic glycolysis and the progression of endometrial cancer. Lentiviral vector transfection was used to up- and downregulate HDAC1 expression in HEC-1-A endometrial cancer cells. The effects of HDAC1 on cellular proliferation, apoptosis, migration, invasiveness and tumorigenesis were determined by CCK-8, flow cytometry, wound-healing, transwell chamber and in vivo tumor formation experiments, respectively. HDAC1 level was significantly increased in endometrial cancer tissues and cells, and its high expression was associated with advanced clinicopathological progression. HEC-1-A cell proliferation, invasiveness, migration and tumorigenesis were enhanced, and apoptosis was inhibited when HDAC1 was overexpressed. Moreover, upregulation of HDAC1 significantly promoted the epithelial-mesenchymal transition of HEC-1-A cells, and increased glucose consumption, lactate secretion and ATP levels. Collectively, the present study revealed that HDAC1 promoted the aerobic glycolysis and progression of endometrial cancer, which may provide a potential target for endometrial cancer treatment. Key words: histone deacetylase 1, growth, epithelial-mesenchymal transition, aerobic glycolysis, migration</abstract><cop>Athens</cop><pub>Spandidos Publications</pub><pmid>34429761</pmid><doi>10.3892/ol.2021.12982</doi><oa>free_for_read</oa></addata></record> |
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| source | Spandidos Publications Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Apoptosis Cancer Cell culture Endometrial cancer Ethylenediaminetetraacetic acid Flow cytometry Glucose metabolism Growth Infection Instrument industry Kinases Laboratories Medical prognosis Metastasis Ovarian cancer Patients Protein expression Proteins Romidepsin Scientific equipment and supplies industry Sodium Surgery |
| title | Histone deacetylase 1 facilitates aerobic glycolysis and growth of endometrial cancer |
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