Tea Polyphenols Enhanced the Antioxidant Capacity and Induced Hsps to Relieve Heat Stress Injury
Keap1-Nrf2-ARE and heat shock proteins (Hsps) are important endogenous protection mechanisms initiated by heat stress to play a double protective role for cell adaptation and survival. H9C2 cells and 80 300-day-old specific pathogen-free chickens were randomly divided into the control and tea polyph...
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| creator | Yin, Bin Lian, Ruirui Li, Zhen Liu, Yueyue Yang, Shifa Huang, Zhongli Zhao, Zengcheng Li, Ying Sun, Chuanxi Lin, Shuqian Wan, Renzhong Li, Guiming |
| description | Keap1-Nrf2-ARE and heat shock proteins (Hsps) are important endogenous protection mechanisms initiated by heat stress to play a double protective role for cell adaptation and survival. H9C2 cells and 80 300-day-old specific pathogen-free chickens were randomly divided into the control and tea polyphenol groups and used to establish a heat stress model in vitro and in vivo. This task was conducted to explore the protection and mechanism of tea polyphenols in relieving thermal injury. A supplement with 10 μg/mL tea polyphenols could effectively relieve the heat damage of H9C2 cells at 42°C. Accordingly, weaker granular degeneration, vacuolar degeneration, and nucleus deep staining were shown. A strong antioxidant capacity was manifested in the upregulation of the total antioxidant capacity (T-AOC) (at 5 h, P |
| doi_str_mv | 10.1155/2021/9615429 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8369192</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2563427458</sourcerecordid><originalsourceid>FETCH-LOGICAL-c448t-adfd7f8842fd201dbd5e662604734ac4510dc679989bff0ec051125b05d484a93</originalsourceid><addsrcrecordid>eNp90c9rFDEUB_BQlP6yN88S8CLUtUkmyU4uQlnabqGgaD2n2eSNk2U2GZNM7f73nXXXRT14eoH34UseX4ReU_KBUiEuGGH0QkkqOFMH6JgqziZEKf5i_ybkCJ3kvCREVozTQ3RUcU4rxdQxergHgz_Hbt23EGKX8VVoTbDgcGkBX4bi45N3JhQ8M72xvqyxCQ7fBjds0Dz3GZeIv0Dn4RHwHEzBX0uCnEezHNL6FXrZmC7D2W6eom_XV_ez-eTu083t7PJuYjmvy8S4xk2buuascYxQt3ACpGSS8GnFjeWCEmflVKlaLZqGgCWCUiYWRDhec6OqU_Rxm9sPixU4C6Ek0-k--ZVJax2N139vgm_19_io60oqqtgY8G4XkOKPAXLRK58tdJ0JEIesmZAVZ1Mu6pG-_Ycu45DCeN4vVUlSy03g-62yKeacoNl_hhK9qU5vqtO76kb-5s8D9vh3VyM434LWB2d--v_HPQPql6Cv</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2563360862</pqid></control><display><type>article</type><title>Tea Polyphenols Enhanced the Antioxidant Capacity and Induced Hsps to Relieve Heat Stress Injury</title><source>MEDLINE</source><source>PubMed Central Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library (Open Access Collection)</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Yin, Bin ; Lian, Ruirui ; Li, Zhen ; Liu, Yueyue ; Yang, Shifa ; Huang, Zhongli ; Zhao, Zengcheng ; Li, Ying ; Sun, Chuanxi ; Lin, Shuqian ; Wan, Renzhong ; Li, Guiming</creator><contributor>Braidy, Nady ; Nady Braidy</contributor><creatorcontrib>Yin, Bin ; Lian, Ruirui ; Li, Zhen ; Liu, Yueyue ; Yang, Shifa ; Huang, Zhongli ; Zhao, Zengcheng ; Li, Ying ; Sun, Chuanxi ; Lin, Shuqian ; Wan, Renzhong ; Li, Guiming ; Braidy, Nady ; Nady Braidy</creatorcontrib><description><![CDATA[Keap1-Nrf2-ARE and heat shock proteins (Hsps) are important endogenous protection mechanisms initiated by heat stress to play a double protective role for cell adaptation and survival. H9C2 cells and 80 300-day-old specific pathogen-free chickens were randomly divided into the control and tea polyphenol groups and used to establish a heat stress model in vitro and in vivo. This task was conducted to explore the protection and mechanism of tea polyphenols in relieving thermal injury. A supplement with 10 μg/mL tea polyphenols could effectively relieve the heat damage of H9C2 cells at 42°C. Accordingly, weaker granular degeneration, vacuolar degeneration, and nucleus deep staining were shown. A strong antioxidant capacity was manifested in the upregulation of the total antioxidant capacity (T-AOC) (at 5 h, P<0.05), Hemeoxygenase-1 mRNA (at 2 h, P<0.01), superoxide dismutase (SOD) (at 2, 3, and 5 h, P<0.05), and Nrf2 (at 0 and 5 h, P<0.01). A high expression of Hsps was reflected in CRYAB at 3 h; Hsp27 at 0, 2, and 3 h (P<0.01); and Hsp70 at 3 and 5 h (P<0.01). The supplement with 0.2 g/L tea polyphenols in the drinking water also had a good effect in alleviating the heat stress damage of the myocardial cells of hens at 38°C. Accordingly, light pathological lesions and downregulation of the myocardial injury-related indicators (LDH, CK, CK-MB, and TNF-α) were shown. The mechanism was related to the upregulation of T-AOC (at 0 h, P<0.05), GSH-PX (at 0.5 d, P<0.01), SOD (at 0.5 d), and Nrf2 (at 0 d with P<0.01 and 2 d with P<0.05) and the induced expression of CRYAB (at 0.5 and 2 d), Hsp27 (at 0, 0.5, and 5 d), and Hsp70 (at 0 and 0.5 d). In conclusion, the tea polyphenols enhanced the antioxidant capacity and induced Hsps to relieve heat stress injury.]]></description><identifier>ISSN: 1942-0900</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2021/9615429</identifier><identifier>PMID: 34413929</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Animals ; Antioxidants ; Antioxidants - pharmacology ; Body temperature ; Cardiomyocytes ; Cell cycle ; Enzymes ; Heat resistance ; Heat shock proteins ; Heat-Shock Proteins - genetics ; Heat-Shock Proteins - metabolism ; Heat-Shock Response ; Homeostasis ; Mice ; Myocytes, Cardiac - drug effects ; Myocytes, Cardiac - metabolism ; Myocytes, Cardiac - pathology ; NF-E2-Related Factor 2 - genetics ; NF-E2-Related Factor 2 - metabolism ; Oxidative Stress ; Polyphenols ; Polyphenols - pharmacology ; Tea - chemistry</subject><ispartof>Oxidative medicine and cellular longevity, 2021, Vol.2021 (1), p.9615429-9615429</ispartof><rights>Copyright © 2021 Bin Yin et al.</rights><rights>Copyright © 2021 Bin Yin et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2021 Bin Yin et al. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-adfd7f8842fd201dbd5e662604734ac4510dc679989bff0ec051125b05d484a93</citedby><cites>FETCH-LOGICAL-c448t-adfd7f8842fd201dbd5e662604734ac4510dc679989bff0ec051125b05d484a93</cites><orcidid>0000-0001-5899-9054 ; 0000-0001-7134-022X ; 0000-0003-4755-0715 ; 0000-0002-4572-7735</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369192/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369192/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34413929$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Braidy, Nady</contributor><contributor>Nady Braidy</contributor><creatorcontrib>Yin, Bin</creatorcontrib><creatorcontrib>Lian, Ruirui</creatorcontrib><creatorcontrib>Li, Zhen</creatorcontrib><creatorcontrib>Liu, Yueyue</creatorcontrib><creatorcontrib>Yang, Shifa</creatorcontrib><creatorcontrib>Huang, Zhongli</creatorcontrib><creatorcontrib>Zhao, Zengcheng</creatorcontrib><creatorcontrib>Li, Ying</creatorcontrib><creatorcontrib>Sun, Chuanxi</creatorcontrib><creatorcontrib>Lin, Shuqian</creatorcontrib><creatorcontrib>Wan, Renzhong</creatorcontrib><creatorcontrib>Li, Guiming</creatorcontrib><title>Tea Polyphenols Enhanced the Antioxidant Capacity and Induced Hsps to Relieve Heat Stress Injury</title><title>Oxidative medicine and cellular longevity</title><addtitle>Oxid Med Cell Longev</addtitle><description><![CDATA[Keap1-Nrf2-ARE and heat shock proteins (Hsps) are important endogenous protection mechanisms initiated by heat stress to play a double protective role for cell adaptation and survival. H9C2 cells and 80 300-day-old specific pathogen-free chickens were randomly divided into the control and tea polyphenol groups and used to establish a heat stress model in vitro and in vivo. This task was conducted to explore the protection and mechanism of tea polyphenols in relieving thermal injury. A supplement with 10 μg/mL tea polyphenols could effectively relieve the heat damage of H9C2 cells at 42°C. Accordingly, weaker granular degeneration, vacuolar degeneration, and nucleus deep staining were shown. A strong antioxidant capacity was manifested in the upregulation of the total antioxidant capacity (T-AOC) (at 5 h, P<0.05), Hemeoxygenase-1 mRNA (at 2 h, P<0.01), superoxide dismutase (SOD) (at 2, 3, and 5 h, P<0.05), and Nrf2 (at 0 and 5 h, P<0.01). A high expression of Hsps was reflected in CRYAB at 3 h; Hsp27 at 0, 2, and 3 h (P<0.01); and Hsp70 at 3 and 5 h (P<0.01). The supplement with 0.2 g/L tea polyphenols in the drinking water also had a good effect in alleviating the heat stress damage of the myocardial cells of hens at 38°C. Accordingly, light pathological lesions and downregulation of the myocardial injury-related indicators (LDH, CK, CK-MB, and TNF-α) were shown. The mechanism was related to the upregulation of T-AOC (at 0 h, P<0.05), GSH-PX (at 0.5 d, P<0.01), SOD (at 0.5 d), and Nrf2 (at 0 d with P<0.01 and 2 d with P<0.05) and the induced expression of CRYAB (at 0.5 and 2 d), Hsp27 (at 0, 0.5, and 5 d), and Hsp70 (at 0 and 0.5 d). In conclusion, the tea polyphenols enhanced the antioxidant capacity and induced Hsps to relieve heat stress injury.]]></description><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>Body temperature</subject><subject>Cardiomyocytes</subject><subject>Cell cycle</subject><subject>Enzymes</subject><subject>Heat resistance</subject><subject>Heat shock proteins</subject><subject>Heat-Shock Proteins - genetics</subject><subject>Heat-Shock Proteins - metabolism</subject><subject>Heat-Shock Response</subject><subject>Homeostasis</subject><subject>Mice</subject><subject>Myocytes, Cardiac - drug effects</subject><subject>Myocytes, Cardiac - metabolism</subject><subject>Myocytes, Cardiac - pathology</subject><subject>NF-E2-Related Factor 2 - genetics</subject><subject>NF-E2-Related Factor 2 - metabolism</subject><subject>Oxidative Stress</subject><subject>Polyphenols</subject><subject>Polyphenols - pharmacology</subject><subject>Tea - 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pharmacology</topic><topic>Body temperature</topic><topic>Cardiomyocytes</topic><topic>Cell cycle</topic><topic>Enzymes</topic><topic>Heat resistance</topic><topic>Heat shock proteins</topic><topic>Heat-Shock Proteins - genetics</topic><topic>Heat-Shock Proteins - metabolism</topic><topic>Heat-Shock Response</topic><topic>Homeostasis</topic><topic>Mice</topic><topic>Myocytes, Cardiac - drug effects</topic><topic>Myocytes, Cardiac - metabolism</topic><topic>Myocytes, Cardiac - pathology</topic><topic>NF-E2-Related Factor 2 - genetics</topic><topic>NF-E2-Related Factor 2 - metabolism</topic><topic>Oxidative Stress</topic><topic>Polyphenols</topic><topic>Polyphenols - pharmacology</topic><topic>Tea - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yin, Bin</creatorcontrib><creatorcontrib>Lian, Ruirui</creatorcontrib><creatorcontrib>Li, Zhen</creatorcontrib><creatorcontrib>Liu, Yueyue</creatorcontrib><creatorcontrib>Yang, Shifa</creatorcontrib><creatorcontrib>Huang, Zhongli</creatorcontrib><creatorcontrib>Zhao, Zengcheng</creatorcontrib><creatorcontrib>Li, Ying</creatorcontrib><creatorcontrib>Sun, Chuanxi</creatorcontrib><creatorcontrib>Lin, Shuqian</creatorcontrib><creatorcontrib>Wan, Renzhong</creatorcontrib><creatorcontrib>Li, Guiming</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oxidative medicine and cellular longevity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yin, Bin</au><au>Lian, Ruirui</au><au>Li, Zhen</au><au>Liu, Yueyue</au><au>Yang, Shifa</au><au>Huang, Zhongli</au><au>Zhao, Zengcheng</au><au>Li, Ying</au><au>Sun, Chuanxi</au><au>Lin, Shuqian</au><au>Wan, Renzhong</au><au>Li, Guiming</au><au>Braidy, Nady</au><au>Nady Braidy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tea Polyphenols Enhanced the Antioxidant Capacity and Induced Hsps to Relieve Heat Stress Injury</atitle><jtitle>Oxidative medicine and cellular longevity</jtitle><addtitle>Oxid Med Cell Longev</addtitle><date>2021</date><risdate>2021</risdate><volume>2021</volume><issue>1</issue><spage>9615429</spage><epage>9615429</epage><pages>9615429-9615429</pages><issn>1942-0900</issn><eissn>1942-0994</eissn><abstract><![CDATA[Keap1-Nrf2-ARE and heat shock proteins (Hsps) are important endogenous protection mechanisms initiated by heat stress to play a double protective role for cell adaptation and survival. H9C2 cells and 80 300-day-old specific pathogen-free chickens were randomly divided into the control and tea polyphenol groups and used to establish a heat stress model in vitro and in vivo. This task was conducted to explore the protection and mechanism of tea polyphenols in relieving thermal injury. A supplement with 10 μg/mL tea polyphenols could effectively relieve the heat damage of H9C2 cells at 42°C. Accordingly, weaker granular degeneration, vacuolar degeneration, and nucleus deep staining were shown. A strong antioxidant capacity was manifested in the upregulation of the total antioxidant capacity (T-AOC) (at 5 h, P<0.05), Hemeoxygenase-1 mRNA (at 2 h, P<0.01), superoxide dismutase (SOD) (at 2, 3, and 5 h, P<0.05), and Nrf2 (at 0 and 5 h, P<0.01). A high expression of Hsps was reflected in CRYAB at 3 h; Hsp27 at 0, 2, and 3 h (P<0.01); and Hsp70 at 3 and 5 h (P<0.01). The supplement with 0.2 g/L tea polyphenols in the drinking water also had a good effect in alleviating the heat stress damage of the myocardial cells of hens at 38°C. Accordingly, light pathological lesions and downregulation of the myocardial injury-related indicators (LDH, CK, CK-MB, and TNF-α) were shown. The mechanism was related to the upregulation of T-AOC (at 0 h, P<0.05), GSH-PX (at 0.5 d, P<0.01), SOD (at 0.5 d), and Nrf2 (at 0 d with P<0.01 and 2 d with P<0.05) and the induced expression of CRYAB (at 0.5 and 2 d), Hsp27 (at 0, 0.5, and 5 d), and Hsp70 (at 0 and 0.5 d). In conclusion, the tea polyphenols enhanced the antioxidant capacity and induced Hsps to relieve heat stress injury.]]></abstract><cop>United States</cop><pub>Hindawi</pub><pmid>34413929</pmid><doi>10.1155/2021/9615429</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-5899-9054</orcidid><orcidid>https://orcid.org/0000-0001-7134-022X</orcidid><orcidid>https://orcid.org/0000-0003-4755-0715</orcidid><orcidid>https://orcid.org/0000-0002-4572-7735</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection); PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Antioxidants Antioxidants - pharmacology Body temperature Cardiomyocytes Cell cycle Enzymes Heat resistance Heat shock proteins Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Heat-Shock Response Homeostasis Mice Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Oxidative Stress Polyphenols Polyphenols - pharmacology Tea - chemistry |
| title | Tea Polyphenols Enhanced the Antioxidant Capacity and Induced Hsps to Relieve Heat Stress Injury |
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