Antioxidant Activity Derived from Marine Green-Lipped Mussel Perna canaliculus Extracts in Mice
This study investigates the antioxidant activities of lipid, protein, and carbohydrate extracts from the marine mollusk Perna canaliculus. Lipids were extracted using acetone, which was followed by protein extraction using the broad-spectrum enzyme Alcalase and then carbohydrate extraction using cet...
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| Veröffentlicht in: | BioMed research international 2021, Vol.2021 (1), p.1622270-1622270 |
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| creator | Alghamdi, Ahmad A. Al-Hazmi, Ayman Almalki, Abdulraheem A. Alsubaihi, Asma A. Anagreyyah, Sulaiman A. Qasem, Ahmed H. Anajirih, Nuha A. Allahyani, Mamdouh Alyamani, Reema A. Albanghali, Mohammad A. Kofiah, Yasser M. Bukhary, Haitham A. Aldairi, Abdullah F. |
| description | This study investigates the antioxidant activities of lipid, protein, and carbohydrate extracts from the marine mollusk Perna canaliculus. Lipids were extracted using acetone, which was followed by protein extraction using the broad-spectrum enzyme Alcalase and then carbohydrate extraction using cetylpyridinium chloride. Eighty white BALB/c mice were divided into eight groups according to the administered extracts. Groups 1 and 5 were the control and toxin control groups, respectively. Groups 2, 3, and 4 were administered lipid, protein, and carbohydrate extracts, respectively. The other groups were administered P. canaliculus extracts as well as gentamicin and acetaminophen, known as ethanolic extracts, derived from Nerium oleander to induce oxidation stress. All groups showed significant improvements in body weight (p |
| doi_str_mv | 10.1155/2021/1622270 |
| format | Article |
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Lipids were extracted using acetone, which was followed by protein extraction using the broad-spectrum enzyme Alcalase and then carbohydrate extraction using cetylpyridinium chloride. Eighty white BALB/c mice were divided into eight groups according to the administered extracts. Groups 1 and 5 were the control and toxin control groups, respectively. Groups 2, 3, and 4 were administered lipid, protein, and carbohydrate extracts, respectively. The other groups were administered P. canaliculus extracts as well as gentamicin and acetaminophen, known as ethanolic extracts, derived from Nerium oleander to induce oxidation stress. All groups showed significant improvements in body weight (p<0.05). The lipid extract group showed a significant decrease in low-density lipoprotein cholesterol (p<0.05) and a significant increase in high-density lipoprotein cholesterol (p<0.05). After the toxin injection, all groups treated with P. canaliculus extracts showed increased antioxidant effects on hepatocytes (p<0.05). The lipid extracts induced antioxidant effects to protect the kidney by increasing lipid peroxidation (p<0.05) and catalase activities (p<0.05). Also, protein extracts showed antioxidant effects by increasing glutathione and catalase levels significantly (p<0.005). In conclusion, P. canaliculus extracts, especially lipids and proteins, have potent antioxidant activities that protect vital organs from oxidation stress.]]></description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2021/1622270</identifier><identifier>PMID: 34409099</identifier><language>eng</language><publisher>New York: Hindawi</publisher><subject>Acetaminophen ; Analgesics ; Analysis ; Antioxidants ; Biomedical research ; Blood ; Body weight ; Bottled water ; Carbohydrates ; Catalase ; Cetylpyridinium chloride ; Cholesterol ; Density ; Enzymes ; Experiments ; Gentamicin ; Glutathione ; Health aspects ; Hematology ; Hepatocytes ; Kidneys ; Lipid peroxidation ; Lipids ; Low density lipoproteins ; Mollusks ; Organs ; Oxidation ; Oxidative stress ; Perna canaliculus ; Peroxidation ; Proteins ; Reactive oxygen species ; Shellfish ; Subtilisin ; Toxins</subject><ispartof>BioMed research international, 2021, Vol.2021 (1), p.1622270-1622270</ispartof><rights>Copyright © 2021 Ahmad A. Alghamdi et al.</rights><rights>COPYRIGHT 2021 John Wiley & Sons, Inc.</rights><rights>Copyright © 2021 Ahmad A. Alghamdi et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2021 Ahmad A. Alghamdi et al. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-7c13a7e0f2cb9a06678ade5cfecc55514f7eb7047d368e10acb7aa639a6264953</citedby><cites>FETCH-LOGICAL-c453t-7c13a7e0f2cb9a06678ade5cfecc55514f7eb7047d368e10acb7aa639a6264953</cites><orcidid>0000-0003-2861-6299 ; 0000-0002-4753-5411 ; 0000-0003-2792-4775 ; 0000-0002-6838-6814 ; 0000-0001-6948-2894 ; 0000-0002-6681-5363 ; 0000-0002-6990-8485</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8367588/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8367588/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids></links><search><contributor>Saidi, Mouldi</contributor><creatorcontrib>Alghamdi, Ahmad A.</creatorcontrib><creatorcontrib>Al-Hazmi, Ayman</creatorcontrib><creatorcontrib>Almalki, Abdulraheem A.</creatorcontrib><creatorcontrib>Alsubaihi, Asma A.</creatorcontrib><creatorcontrib>Anagreyyah, Sulaiman A.</creatorcontrib><creatorcontrib>Qasem, Ahmed H.</creatorcontrib><creatorcontrib>Anajirih, Nuha A.</creatorcontrib><creatorcontrib>Allahyani, Mamdouh</creatorcontrib><creatorcontrib>Alyamani, Reema A.</creatorcontrib><creatorcontrib>Albanghali, Mohammad A.</creatorcontrib><creatorcontrib>Kofiah, Yasser M.</creatorcontrib><creatorcontrib>Bukhary, Haitham A.</creatorcontrib><creatorcontrib>Aldairi, Abdullah F.</creatorcontrib><title>Antioxidant Activity Derived from Marine Green-Lipped Mussel Perna canaliculus Extracts in Mice</title><title>BioMed research international</title><description><![CDATA[This study investigates the antioxidant activities of lipid, protein, and carbohydrate extracts from the marine mollusk Perna canaliculus. Lipids were extracted using acetone, which was followed by protein extraction using the broad-spectrum enzyme Alcalase and then carbohydrate extraction using cetylpyridinium chloride. Eighty white BALB/c mice were divided into eight groups according to the administered extracts. Groups 1 and 5 were the control and toxin control groups, respectively. Groups 2, 3, and 4 were administered lipid, protein, and carbohydrate extracts, respectively. The other groups were administered P. canaliculus extracts as well as gentamicin and acetaminophen, known as ethanolic extracts, derived from Nerium oleander to induce oxidation stress. All groups showed significant improvements in body weight (p<0.05). The lipid extract group showed a significant decrease in low-density lipoprotein cholesterol (p<0.05) and a significant increase in high-density lipoprotein cholesterol (p<0.05). After the toxin injection, all groups treated with P. canaliculus extracts showed increased antioxidant effects on hepatocytes (p<0.05). The lipid extracts induced antioxidant effects to protect the kidney by increasing lipid peroxidation (p<0.05) and catalase activities (p<0.05). Also, protein extracts showed antioxidant effects by increasing glutathione and catalase levels significantly (p<0.005). In conclusion, P. canaliculus extracts, especially lipids and proteins, have potent antioxidant activities that protect vital organs from oxidation stress.]]></description><subject>Acetaminophen</subject><subject>Analgesics</subject><subject>Analysis</subject><subject>Antioxidants</subject><subject>Biomedical research</subject><subject>Blood</subject><subject>Body weight</subject><subject>Bottled water</subject><subject>Carbohydrates</subject><subject>Catalase</subject><subject>Cetylpyridinium chloride</subject><subject>Cholesterol</subject><subject>Density</subject><subject>Enzymes</subject><subject>Experiments</subject><subject>Gentamicin</subject><subject>Glutathione</subject><subject>Health aspects</subject><subject>Hematology</subject><subject>Hepatocytes</subject><subject>Kidneys</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Low density lipoproteins</subject><subject>Mollusks</subject><subject>Organs</subject><subject>Oxidation</subject><subject>Oxidative stress</subject><subject>Perna canaliculus</subject><subject>Peroxidation</subject><subject>Proteins</subject><subject>Reactive oxygen 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Activity Derived from Marine Green-Lipped Mussel Perna canaliculus Extracts in Mice</title><author>Alghamdi, Ahmad A. ; Al-Hazmi, Ayman ; Almalki, Abdulraheem A. ; Alsubaihi, Asma A. ; Anagreyyah, Sulaiman A. ; Qasem, Ahmed H. ; Anajirih, Nuha A. ; Allahyani, Mamdouh ; Alyamani, Reema A. ; Albanghali, Mohammad A. ; Kofiah, Yasser M. ; Bukhary, Haitham A. ; Aldairi, Abdullah F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-7c13a7e0f2cb9a06678ade5cfecc55514f7eb7047d368e10acb7aa639a6264953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acetaminophen</topic><topic>Analgesics</topic><topic>Analysis</topic><topic>Antioxidants</topic><topic>Biomedical research</topic><topic>Blood</topic><topic>Body weight</topic><topic>Bottled water</topic><topic>Carbohydrates</topic><topic>Catalase</topic><topic>Cetylpyridinium 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H.</au><au>Anajirih, Nuha A.</au><au>Allahyani, Mamdouh</au><au>Alyamani, Reema A.</au><au>Albanghali, Mohammad A.</au><au>Kofiah, Yasser M.</au><au>Bukhary, Haitham A.</au><au>Aldairi, Abdullah F.</au><au>Saidi, Mouldi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antioxidant Activity Derived from Marine Green-Lipped Mussel Perna canaliculus Extracts in Mice</atitle><jtitle>BioMed research international</jtitle><date>2021</date><risdate>2021</risdate><volume>2021</volume><issue>1</issue><spage>1622270</spage><epage>1622270</epage><pages>1622270-1622270</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract><![CDATA[This study investigates the antioxidant activities of lipid, protein, and carbohydrate extracts from the marine mollusk Perna canaliculus. Lipids were extracted using acetone, which was followed by protein extraction using the broad-spectrum enzyme Alcalase and then carbohydrate extraction using cetylpyridinium chloride. Eighty white BALB/c mice were divided into eight groups according to the administered extracts. Groups 1 and 5 were the control and toxin control groups, respectively. Groups 2, 3, and 4 were administered lipid, protein, and carbohydrate extracts, respectively. The other groups were administered P. canaliculus extracts as well as gentamicin and acetaminophen, known as ethanolic extracts, derived from Nerium oleander to induce oxidation stress. All groups showed significant improvements in body weight (p<0.05). The lipid extract group showed a significant decrease in low-density lipoprotein cholesterol (p<0.05) and a significant increase in high-density lipoprotein cholesterol (p<0.05). After the toxin injection, all groups treated with P. canaliculus extracts showed increased antioxidant effects on hepatocytes (p<0.05). The lipid extracts induced antioxidant effects to protect the kidney by increasing lipid peroxidation (p<0.05) and catalase activities (p<0.05). Also, protein extracts showed antioxidant effects by increasing glutathione and catalase levels significantly (p<0.005). In conclusion, P. canaliculus extracts, especially lipids and proteins, have potent antioxidant activities that protect vital organs from oxidation stress.]]></abstract><cop>New York</cop><pub>Hindawi</pub><pmid>34409099</pmid><doi>10.1155/2021/1622270</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-2861-6299</orcidid><orcidid>https://orcid.org/0000-0002-4753-5411</orcidid><orcidid>https://orcid.org/0000-0003-2792-4775</orcidid><orcidid>https://orcid.org/0000-0002-6838-6814</orcidid><orcidid>https://orcid.org/0000-0001-6948-2894</orcidid><orcidid>https://orcid.org/0000-0002-6681-5363</orcidid><orcidid>https://orcid.org/0000-0002-6990-8485</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library Open Access; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Acetaminophen Analgesics Analysis Antioxidants Biomedical research Blood Body weight Bottled water Carbohydrates Catalase Cetylpyridinium chloride Cholesterol Density Enzymes Experiments Gentamicin Glutathione Health aspects Hematology Hepatocytes Kidneys Lipid peroxidation Lipids Low density lipoproteins Mollusks Organs Oxidation Oxidative stress Perna canaliculus Peroxidation Proteins Reactive oxygen species Shellfish Subtilisin Toxins |
| title | Antioxidant Activity Derived from Marine Green-Lipped Mussel Perna canaliculus Extracts in Mice |
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