Caregiver-reported delay in presentation to pediatric emergency departments for fear of contracting COVID-19: a multi-national cross-sectional study

Objective To determine if caregivers of children presenting to pediatric emergency departments (EDs) during the COVID-19 pandemic are delaying presenting to care for fear of contracting COVID-19. Methods This was a pre-planned secondary analysis of a cross-sectional survey study of caregivers accomp...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Canadian journal of emergency medicine 2021-11, Vol.23 (6), p.778-786
Hauptverfasser: Davis, Adrienne L., Sunderji, Alia, Marneni, Shashidhar R., Seiler, Michelle, Hall, Jeanine E., Cotanda, Cristina Parra, Klein, Eileen J., Brown, Julie C., Gelernter, Renana, Griffiths, Mark A., Hoeffe, Julia, Gualco, Gianluca, Mater, Ahmed, Manzano, Sergio, Thompson, Graham C., Ahmed, Sara, Ali, Samina, Goldman, Ran D.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 786
container_issue 6
container_start_page 778
container_title Canadian journal of emergency medicine
container_volume 23
creator Davis, Adrienne L.
Sunderji, Alia
Marneni, Shashidhar R.
Seiler, Michelle
Hall, Jeanine E.
Cotanda, Cristina Parra
Klein, Eileen J.
Brown, Julie C.
Gelernter, Renana
Griffiths, Mark A.
Hoeffe, Julia
Gualco, Gianluca
Mater, Ahmed
Manzano, Sergio
Thompson, Graham C.
Ahmed, Sara
Ali, Samina
Goldman, Ran D.
description Objective To determine if caregivers of children presenting to pediatric emergency departments (EDs) during the COVID-19 pandemic are delaying presenting to care for fear of contracting COVID-19. Methods This was a pre-planned secondary analysis of a cross-sectional survey study of caregivers accompanying their children aged 0–19 years to 16 pediatric EDs in 5 countries from May to June 2020. An anonymous online survey, completed by caregivers via RedCAP, included caregiver and child demographics, presenting complaints, if they delayed presentation and whether symptoms worsened during this interval, as well as caregiver concern about the child or caregiver having COVID-19 at the time of ED visit. Results Of 1543 caregivers completing the survey, 287 (18.6%) reported a delay in seeking ED care due to concerns of contracting COVID-19 in the hospital. Of those, 124 (43.2%) stated their child’s symptoms worsened during the waiting interval. Caregiver relationship to child [mother] (OR 1.85, 95% CI 1.27–2.76), presence of chronic illness in child (OR 1.78. 95% CI 1.14–2.79), younger age of caregiver (OR 0.965, 95% CI 0.943–0.986), and caregiver concerns about lost work during the pandemic (OR 1.08, 95% CI 1.04–1.12) were independently associated with a COVID-19-related delayed presentation in multivariable regression analysis. Conclusions Almost one in five caregivers reported delaying ED presentation for their ill or injured child specifically due to fear of contracting COVID-19 while in hospital, with mothers, younger caregivers, caregivers of children with chronic illness, and those concerned about lost work more likely to report delaying ED presentation.
doi_str_mv 10.1007/s43678-021-00174-z
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8366744</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2562233728</sourcerecordid><originalsourceid>FETCH-LOGICAL-c451t-b8344ade18b9307c5fa0d3b20ef0ce70794de7479ef4ffade3ad43c562f5ff003</originalsourceid><addsrcrecordid>eNp9kctuFDEQRS1ERB7wA6wssWHj4Fe3e1ggoQmPSJGyCWwtj7vcOOq2G9sdafIdfDDOzCiILLKyrTr3VpUvQm8ZPWeUqg9ZilZ1hHJGKGVKkvsX6ITJjpGOSvHy8S6aY3Sa822FeMO6V-hYSEk5Fe0J-rM2CQZ_B4kkmGMq0OMeRrPFPuA5QYZQTPEx4BLxDL03JXmLYYI0QLDbCs8mlaliGbuYsAOTcHTYxlCSscWHAa-vf15eELb6iA2elrF4EnaeZsQ2xZxJBnt457L029foyJkxw5vDeYZ-fP1ys_5Orq6_Xa4_XxErG1bIpqt7mB5Yt1kJqmzjDO3FhlNw1IKiaiV7UFKtwEnnKihML4VtWu4a5ygVZ-jT3ndeNhP0Fh5GHvWc_GTSVkfj9f-V4H_pId7pTrStkrIavD8YpPh7gVz05LOFcTQB4pI1r724EIp3FX33BL2NS6orV0qxjvNWCF4pvqd2_5LAPQ7DqH4IXe9D1zV0vQtd31eR2ItyhcMA6Z_1M6q_aj6yyA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2718226332</pqid></control><display><type>article</type><title>Caregiver-reported delay in presentation to pediatric emergency departments for fear of contracting COVID-19: a multi-national cross-sectional study</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Springer Nature - Complete Springer Journals</source><creator>Davis, Adrienne L. ; Sunderji, Alia ; Marneni, Shashidhar R. ; Seiler, Michelle ; Hall, Jeanine E. ; Cotanda, Cristina Parra ; Klein, Eileen J. ; Brown, Julie C. ; Gelernter, Renana ; Griffiths, Mark A. ; Hoeffe, Julia ; Gualco, Gianluca ; Mater, Ahmed ; Manzano, Sergio ; Thompson, Graham C. ; Ahmed, Sara ; Ali, Samina ; Goldman, Ran D.</creator><creatorcontrib>Davis, Adrienne L. ; Sunderji, Alia ; Marneni, Shashidhar R. ; Seiler, Michelle ; Hall, Jeanine E. ; Cotanda, Cristina Parra ; Klein, Eileen J. ; Brown, Julie C. ; Gelernter, Renana ; Griffiths, Mark A. ; Hoeffe, Julia ; Gualco, Gianluca ; Mater, Ahmed ; Manzano, Sergio ; Thompson, Graham C. ; Ahmed, Sara ; Ali, Samina ; Goldman, Ran D. ; For the International COVID-19 Parental Attitude Study (COVIPAS) Group</creatorcontrib><description>Objective To determine if caregivers of children presenting to pediatric emergency departments (EDs) during the COVID-19 pandemic are delaying presenting to care for fear of contracting COVID-19. Methods This was a pre-planned secondary analysis of a cross-sectional survey study of caregivers accompanying their children aged 0–19 years to 16 pediatric EDs in 5 countries from May to June 2020. An anonymous online survey, completed by caregivers via RedCAP, included caregiver and child demographics, presenting complaints, if they delayed presentation and whether symptoms worsened during this interval, as well as caregiver concern about the child or caregiver having COVID-19 at the time of ED visit. Results Of 1543 caregivers completing the survey, 287 (18.6%) reported a delay in seeking ED care due to concerns of contracting COVID-19 in the hospital. Of those, 124 (43.2%) stated their child’s symptoms worsened during the waiting interval. Caregiver relationship to child [mother] (OR 1.85, 95% CI 1.27–2.76), presence of chronic illness in child (OR 1.78. 95% CI 1.14–2.79), younger age of caregiver (OR 0.965, 95% CI 0.943–0.986), and caregiver concerns about lost work during the pandemic (OR 1.08, 95% CI 1.04–1.12) were independently associated with a COVID-19-related delayed presentation in multivariable regression analysis. Conclusions Almost one in five caregivers reported delaying ED presentation for their ill or injured child specifically due to fear of contracting COVID-19 while in hospital, with mothers, younger caregivers, caregivers of children with chronic illness, and those concerned about lost work more likely to report delaying ED presentation.</description><identifier>ISSN: 1481-8035</identifier><identifier>EISSN: 1481-8043</identifier><identifier>DOI: 10.1007/s43678-021-00174-z</identifier><identifier>PMID: 34402036</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Caregivers ; Children &amp; youth ; Chronic illnesses ; Coronaviruses ; COVID-19 ; Cross-sectional studies ; Emergency Medicine ; Medicine ; Medicine &amp; Public Health ; Original Research ; Pandemics ; Pediatrics ; Public Health</subject><ispartof>Canadian journal of emergency medicine, 2021-11, Vol.23 (6), p.778-786</ispartof><rights>The Author(s), under exclusive licence to Canadian Association of Emergency Physicians (CAEP)/ Association Canadienne de Médecine d'Urgence (ACMU) 2021</rights><rights>The Author(s), under exclusive licence to Canadian Association of Emergency Physicians (CAEP)/ Association Canadienne de Médecine d'Urgence (ACMU) 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-b8344ade18b9307c5fa0d3b20ef0ce70794de7479ef4ffade3ad43c562f5ff003</citedby><cites>FETCH-LOGICAL-c451t-b8344ade18b9307c5fa0d3b20ef0ce70794de7479ef4ffade3ad43c562f5ff003</cites><orcidid>0000-0002-2780-707X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s43678-021-00174-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s43678-021-00174-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,778,782,883,27913,27914,41477,42546,51308</link.rule.ids></links><search><creatorcontrib>Davis, Adrienne L.</creatorcontrib><creatorcontrib>Sunderji, Alia</creatorcontrib><creatorcontrib>Marneni, Shashidhar R.</creatorcontrib><creatorcontrib>Seiler, Michelle</creatorcontrib><creatorcontrib>Hall, Jeanine E.</creatorcontrib><creatorcontrib>Cotanda, Cristina Parra</creatorcontrib><creatorcontrib>Klein, Eileen J.</creatorcontrib><creatorcontrib>Brown, Julie C.</creatorcontrib><creatorcontrib>Gelernter, Renana</creatorcontrib><creatorcontrib>Griffiths, Mark A.</creatorcontrib><creatorcontrib>Hoeffe, Julia</creatorcontrib><creatorcontrib>Gualco, Gianluca</creatorcontrib><creatorcontrib>Mater, Ahmed</creatorcontrib><creatorcontrib>Manzano, Sergio</creatorcontrib><creatorcontrib>Thompson, Graham C.</creatorcontrib><creatorcontrib>Ahmed, Sara</creatorcontrib><creatorcontrib>Ali, Samina</creatorcontrib><creatorcontrib>Goldman, Ran D.</creatorcontrib><creatorcontrib>For the International COVID-19 Parental Attitude Study (COVIPAS) Group</creatorcontrib><title>Caregiver-reported delay in presentation to pediatric emergency departments for fear of contracting COVID-19: a multi-national cross-sectional study</title><title>Canadian journal of emergency medicine</title><addtitle>Can J Emerg Med</addtitle><description>Objective To determine if caregivers of children presenting to pediatric emergency departments (EDs) during the COVID-19 pandemic are delaying presenting to care for fear of contracting COVID-19. Methods This was a pre-planned secondary analysis of a cross-sectional survey study of caregivers accompanying their children aged 0–19 years to 16 pediatric EDs in 5 countries from May to June 2020. An anonymous online survey, completed by caregivers via RedCAP, included caregiver and child demographics, presenting complaints, if they delayed presentation and whether symptoms worsened during this interval, as well as caregiver concern about the child or caregiver having COVID-19 at the time of ED visit. Results Of 1543 caregivers completing the survey, 287 (18.6%) reported a delay in seeking ED care due to concerns of contracting COVID-19 in the hospital. Of those, 124 (43.2%) stated their child’s symptoms worsened during the waiting interval. Caregiver relationship to child [mother] (OR 1.85, 95% CI 1.27–2.76), presence of chronic illness in child (OR 1.78. 95% CI 1.14–2.79), younger age of caregiver (OR 0.965, 95% CI 0.943–0.986), and caregiver concerns about lost work during the pandemic (OR 1.08, 95% CI 1.04–1.12) were independently associated with a COVID-19-related delayed presentation in multivariable regression analysis. Conclusions Almost one in five caregivers reported delaying ED presentation for their ill or injured child specifically due to fear of contracting COVID-19 while in hospital, with mothers, younger caregivers, caregivers of children with chronic illness, and those concerned about lost work more likely to report delaying ED presentation.</description><subject>Caregivers</subject><subject>Children &amp; youth</subject><subject>Chronic illnesses</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Cross-sectional studies</subject><subject>Emergency Medicine</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Original Research</subject><subject>Pandemics</subject><subject>Pediatrics</subject><subject>Public Health</subject><issn>1481-8035</issn><issn>1481-8043</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kctuFDEQRS1ERB7wA6wssWHj4Fe3e1ggoQmPSJGyCWwtj7vcOOq2G9sdafIdfDDOzCiILLKyrTr3VpUvQm8ZPWeUqg9ZilZ1hHJGKGVKkvsX6ITJjpGOSvHy8S6aY3Sa822FeMO6V-hYSEk5Fe0J-rM2CQZ_B4kkmGMq0OMeRrPFPuA5QYZQTPEx4BLxDL03JXmLYYI0QLDbCs8mlaliGbuYsAOTcHTYxlCSscWHAa-vf15eELb6iA2elrF4EnaeZsQ2xZxJBnt457L029foyJkxw5vDeYZ-fP1ys_5Orq6_Xa4_XxErG1bIpqt7mB5Yt1kJqmzjDO3FhlNw1IKiaiV7UFKtwEnnKihML4VtWu4a5ygVZ-jT3ndeNhP0Fh5GHvWc_GTSVkfj9f-V4H_pId7pTrStkrIavD8YpPh7gVz05LOFcTQB4pI1r724EIp3FX33BL2NS6orV0qxjvNWCF4pvqd2_5LAPQ7DqH4IXe9D1zV0vQtd31eR2ItyhcMA6Z_1M6q_aj6yyA</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Davis, Adrienne L.</creator><creator>Sunderji, Alia</creator><creator>Marneni, Shashidhar R.</creator><creator>Seiler, Michelle</creator><creator>Hall, Jeanine E.</creator><creator>Cotanda, Cristina Parra</creator><creator>Klein, Eileen J.</creator><creator>Brown, Julie C.</creator><creator>Gelernter, Renana</creator><creator>Griffiths, Mark A.</creator><creator>Hoeffe, Julia</creator><creator>Gualco, Gianluca</creator><creator>Mater, Ahmed</creator><creator>Manzano, Sergio</creator><creator>Thompson, Graham C.</creator><creator>Ahmed, Sara</creator><creator>Ali, Samina</creator><creator>Goldman, Ran D.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>4T-</scope><scope>4U-</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2780-707X</orcidid></search><sort><creationdate>20211101</creationdate><title>Caregiver-reported delay in presentation to pediatric emergency departments for fear of contracting COVID-19: a multi-national cross-sectional study</title><author>Davis, Adrienne L. ; Sunderji, Alia ; Marneni, Shashidhar R. ; Seiler, Michelle ; Hall, Jeanine E. ; Cotanda, Cristina Parra ; Klein, Eileen J. ; Brown, Julie C. ; Gelernter, Renana ; Griffiths, Mark A. ; Hoeffe, Julia ; Gualco, Gianluca ; Mater, Ahmed ; Manzano, Sergio ; Thompson, Graham C. ; Ahmed, Sara ; Ali, Samina ; Goldman, Ran D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-b8344ade18b9307c5fa0d3b20ef0ce70794de7479ef4ffade3ad43c562f5ff003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Caregivers</topic><topic>Children &amp; youth</topic><topic>Chronic illnesses</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Cross-sectional studies</topic><topic>Emergency Medicine</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Original Research</topic><topic>Pandemics</topic><topic>Pediatrics</topic><topic>Public Health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Davis, Adrienne L.</creatorcontrib><creatorcontrib>Sunderji, Alia</creatorcontrib><creatorcontrib>Marneni, Shashidhar R.</creatorcontrib><creatorcontrib>Seiler, Michelle</creatorcontrib><creatorcontrib>Hall, Jeanine E.</creatorcontrib><creatorcontrib>Cotanda, Cristina Parra</creatorcontrib><creatorcontrib>Klein, Eileen J.</creatorcontrib><creatorcontrib>Brown, Julie C.</creatorcontrib><creatorcontrib>Gelernter, Renana</creatorcontrib><creatorcontrib>Griffiths, Mark A.</creatorcontrib><creatorcontrib>Hoeffe, Julia</creatorcontrib><creatorcontrib>Gualco, Gianluca</creatorcontrib><creatorcontrib>Mater, Ahmed</creatorcontrib><creatorcontrib>Manzano, Sergio</creatorcontrib><creatorcontrib>Thompson, Graham C.</creatorcontrib><creatorcontrib>Ahmed, Sara</creatorcontrib><creatorcontrib>Ali, Samina</creatorcontrib><creatorcontrib>Goldman, Ran D.</creatorcontrib><creatorcontrib>For the International COVID-19 Parental Attitude Study (COVIPAS) Group</creatorcontrib><collection>CrossRef</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Canadian journal of emergency medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Davis, Adrienne L.</au><au>Sunderji, Alia</au><au>Marneni, Shashidhar R.</au><au>Seiler, Michelle</au><au>Hall, Jeanine E.</au><au>Cotanda, Cristina Parra</au><au>Klein, Eileen J.</au><au>Brown, Julie C.</au><au>Gelernter, Renana</au><au>Griffiths, Mark A.</au><au>Hoeffe, Julia</au><au>Gualco, Gianluca</au><au>Mater, Ahmed</au><au>Manzano, Sergio</au><au>Thompson, Graham C.</au><au>Ahmed, Sara</au><au>Ali, Samina</au><au>Goldman, Ran D.</au><aucorp>For the International COVID-19 Parental Attitude Study (COVIPAS) Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Caregiver-reported delay in presentation to pediatric emergency departments for fear of contracting COVID-19: a multi-national cross-sectional study</atitle><jtitle>Canadian journal of emergency medicine</jtitle><stitle>Can J Emerg Med</stitle><date>2021-11-01</date><risdate>2021</risdate><volume>23</volume><issue>6</issue><spage>778</spage><epage>786</epage><pages>778-786</pages><issn>1481-8035</issn><eissn>1481-8043</eissn><abstract>Objective To determine if caregivers of children presenting to pediatric emergency departments (EDs) during the COVID-19 pandemic are delaying presenting to care for fear of contracting COVID-19. Methods This was a pre-planned secondary analysis of a cross-sectional survey study of caregivers accompanying their children aged 0–19 years to 16 pediatric EDs in 5 countries from May to June 2020. An anonymous online survey, completed by caregivers via RedCAP, included caregiver and child demographics, presenting complaints, if they delayed presentation and whether symptoms worsened during this interval, as well as caregiver concern about the child or caregiver having COVID-19 at the time of ED visit. Results Of 1543 caregivers completing the survey, 287 (18.6%) reported a delay in seeking ED care due to concerns of contracting COVID-19 in the hospital. Of those, 124 (43.2%) stated their child’s symptoms worsened during the waiting interval. Caregiver relationship to child [mother] (OR 1.85, 95% CI 1.27–2.76), presence of chronic illness in child (OR 1.78. 95% CI 1.14–2.79), younger age of caregiver (OR 0.965, 95% CI 0.943–0.986), and caregiver concerns about lost work during the pandemic (OR 1.08, 95% CI 1.04–1.12) were independently associated with a COVID-19-related delayed presentation in multivariable regression analysis. Conclusions Almost one in five caregivers reported delaying ED presentation for their ill or injured child specifically due to fear of contracting COVID-19 while in hospital, with mothers, younger caregivers, caregivers of children with chronic illness, and those concerned about lost work more likely to report delaying ED presentation.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>34402036</pmid><doi>10.1007/s43678-021-00174-z</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-2780-707X</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1481-8035
ispartof Canadian journal of emergency medicine, 2021-11, Vol.23 (6), p.778-786
issn 1481-8035
1481-8043
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8366744
source Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature - Complete Springer Journals
subjects Caregivers
Children & youth
Chronic illnesses
Coronaviruses
COVID-19
Cross-sectional studies
Emergency Medicine
Medicine
Medicine & Public Health
Original Research
Pandemics
Pediatrics
Public Health
title Caregiver-reported delay in presentation to pediatric emergency departments for fear of contracting COVID-19: a multi-national cross-sectional study
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T09%3A28%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Caregiver-reported%20delay%20in%20presentation%20to%20pediatric%20emergency%20departments%20for%20fear%20of%20contracting%20COVID-19:%20a%20multi-national%20cross-sectional%20study&rft.jtitle=Canadian%20journal%20of%20emergency%20medicine&rft.au=Davis,%20Adrienne%20L.&rft.aucorp=For%20the%20International%20COVID-19%20Parental%20Attitude%20Study%20(COVIPAS)%20Group&rft.date=2021-11-01&rft.volume=23&rft.issue=6&rft.spage=778&rft.epage=786&rft.pages=778-786&rft.issn=1481-8035&rft.eissn=1481-8043&rft_id=info:doi/10.1007/s43678-021-00174-z&rft_dat=%3Cproquest_pubme%3E2562233728%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2718226332&rft_id=info:pmid/34402036&rfr_iscdi=true