Who's in control? Principles of Rab GTPase activation in endolysosomal membrane trafficking and beyond
The eukaryotic endomembrane system consists of multiple interconnected organelles. Rab GTPases are organelle-specific markers that give identity to these membranes by recruiting transport and trafficking proteins. During transport processes or along organelle maturation, one Rab is replaced by anoth...
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| Veröffentlicht in: | The Journal of cell biology 2021-09, Vol.220 (9), p.1 |
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| creator | Borchers, Ann-Christin Langemeyer, Lars Ungermann, Christian |
| description | The eukaryotic endomembrane system consists of multiple interconnected organelles. Rab GTPases are organelle-specific markers that give identity to these membranes by recruiting transport and trafficking proteins. During transport processes or along organelle maturation, one Rab is replaced by another, a process termed Rab cascade, which requires at its center a Rab-specific guanine nucleotide exchange factor (GEF). The endolysosomal system serves here as a prime example for a Rab cascade. Along with endosomal maturation, the endosomal Rab5 recruits and activates the Rab7-specific GEF Mon1-Ccz1, resulting in Rab7 activation on endosomes and subsequent fusion of endosomes with lysosomes. In this review, we focus on the current idea of Mon1-Ccz1 recruitment and activation in the endolysosomal and autophagic pathway. We compare identified principles to other GTPase cascades on endomembranes, highlight the importance of regulation, and evaluate in this context the strength and relevance of recent developments in in vitro analyses to understand the underlying foundation of organelle biogenesis and maturation. |
| doi_str_mv | 10.1083/jcb.202105120 |
| format | Article |
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Principles of Rab GTPase activation in endolysosomal membrane trafficking and beyond</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Borchers, Ann-Christin ; Langemeyer, Lars ; Ungermann, Christian</creator><creatorcontrib>Borchers, Ann-Christin ; Langemeyer, Lars ; Ungermann, Christian</creatorcontrib><description>The eukaryotic endomembrane system consists of multiple interconnected organelles. Rab GTPases are organelle-specific markers that give identity to these membranes by recruiting transport and trafficking proteins. During transport processes or along organelle maturation, one Rab is replaced by another, a process termed Rab cascade, which requires at its center a Rab-specific guanine nucleotide exchange factor (GEF). The endolysosomal system serves here as a prime example for a Rab cascade. Along with endosomal maturation, the endosomal Rab5 recruits and activates the Rab7-specific GEF Mon1-Ccz1, resulting in Rab7 activation on endosomes and subsequent fusion of endosomes with lysosomes. In this review, we focus on the current idea of Mon1-Ccz1 recruitment and activation in the endolysosomal and autophagic pathway. 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Principles of Rab GTPase activation in endolysosomal membrane trafficking and beyond</title><title>The Journal of cell biology</title><addtitle>J Cell Biol</addtitle><description>The eukaryotic endomembrane system consists of multiple interconnected organelles. Rab GTPases are organelle-specific markers that give identity to these membranes by recruiting transport and trafficking proteins. During transport processes or along organelle maturation, one Rab is replaced by another, a process termed Rab cascade, which requires at its center a Rab-specific guanine nucleotide exchange factor (GEF). The endolysosomal system serves here as a prime example for a Rab cascade. Along with endosomal maturation, the endosomal Rab5 recruits and activates the Rab7-specific GEF Mon1-Ccz1, resulting in Rab7 activation on endosomes and subsequent fusion of endosomes with lysosomes. In this review, we focus on the current idea of Mon1-Ccz1 recruitment and activation in the endolysosomal and autophagic pathway. We compare identified principles to other GTPase cascades on endomembranes, highlight the importance of regulation, and evaluate in this context the strength and relevance of recent developments in in vitro analyses to understand the underlying foundation of organelle biogenesis and maturation.</description><subject>Animals</subject><subject>Autophagosomes - genetics</subject><subject>Autophagosomes - metabolism</subject><subject>Biochemistry</subject><subject>Biological Transport</subject><subject>Cell Membrane - genetics</subject><subject>Cell Membrane - metabolism</subject><subject>Conserved Sequence</subject><subject>Endosomes</subject><subject>Endosomes - genetics</subject><subject>Endosomes - metabolism</subject><subject>Gene Expression Regulation</subject><subject>Guanine</subject><subject>Guanine nucleotide exchange factor</subject><subject>Guanine Nucleotide Exchange Factors - genetics</subject><subject>Guanine Nucleotide Exchange Factors - metabolism</subject><subject>Guanosine triphosphatases</subject><subject>Humans</subject><subject>Lysosomes</subject><subject>Lysosomes - genetics</subject><subject>Lysosomes - metabolism</subject><subject>Maturation</subject><subject>Membrane trafficking</subject><subject>Membranes</subject><subject>Nucleotides</subject><subject>Organelle Biogenesis</subject><subject>Organelles</subject><subject>Principles</subject><subject>Protein transport</subject><subject>rab GTP-Binding Proteins - genetics</subject><subject>rab GTP-Binding Proteins - metabolism</subject><subject>rab5 GTP-Binding Proteins - genetics</subject><subject>rab5 GTP-Binding Proteins - metabolism</subject><subject>rab7 GTP-Binding Proteins</subject><subject>Recruitment</subject><subject>Review</subject><subject>Saccharomyces cerevisiae - genetics</subject><subject>Saccharomyces cerevisiae - metabolism</subject><subject>Saccharomyces cerevisiae Proteins - genetics</subject><subject>Saccharomyces cerevisiae Proteins - metabolism</subject><subject>Signal Transduction</subject><subject>Trafficking</subject><subject>Transport processes</subject><subject>Vesicular Transport Proteins - genetics</subject><subject>Vesicular Transport Proteins - metabolism</subject><issn>0021-9525</issn><issn>1540-8140</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkcFLHDEUh4O06FZ79CqBHtrL2JdJMpO9WIq0tiBUxNJjeMkkmnUmWZNZYf_7RrRL21Pg5ePH-96PkGMGpwwU_7iy5rSFloFkLeyRBZMCGsUEvCILqPNmKVt5QN6UsgIA0Qu-Tw644IoD4wvif92l94WGSG2Kc07jJ3qVQ7RhPbpCk6fXaOjFzRUWR9HO4RHnkOIT7-KQxm1JJU040slNJmN0dM7ofbD3Id5SjAM1bpvicEReexyLe_vyHpKfX7_cnH9rLn9cfD__fNlYweTcVA3lnfSAVg0eGe-XnUFRNWxvDSjBQaJX0nSdNYZxI2GwXBgrkIl-CfyQnD3nrjdmcoN11QlHvc5hwrzVCYP-9yeGO32bHrXiXdczVgM-vATk9LBxZdZTKNaNY3VLm6Jb2dWrs65vK_ruP3SVNjlWvUr10NYjC1Wp5pmyOZWSnd8tw0A_Nahrg3rXYOVP_jbY0X8q478Bly6Xjg</recordid><startdate>20210906</startdate><enddate>20210906</enddate><creator>Borchers, Ann-Christin</creator><creator>Langemeyer, Lars</creator><creator>Ungermann, Christian</creator><general>Rockefeller University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4309-0910</orcidid><orcidid>https://orcid.org/0000-0003-2466-0129</orcidid><orcidid>https://orcid.org/0000-0003-4331-8695</orcidid></search><sort><creationdate>20210906</creationdate><title>Who's in control? Principles of Rab GTPase activation in endolysosomal membrane trafficking and beyond</title><author>Borchers, Ann-Christin ; Langemeyer, Lars ; Ungermann, Christian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-2108fe5f0ac8dfa13796ba4021c7cb084305af85b66cbb13b50dc34bc4a147903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Autophagosomes - genetics</topic><topic>Autophagosomes - metabolism</topic><topic>Biochemistry</topic><topic>Biological Transport</topic><topic>Cell Membrane - genetics</topic><topic>Cell Membrane - metabolism</topic><topic>Conserved Sequence</topic><topic>Endosomes</topic><topic>Endosomes - genetics</topic><topic>Endosomes - metabolism</topic><topic>Gene Expression Regulation</topic><topic>Guanine</topic><topic>Guanine nucleotide exchange factor</topic><topic>Guanine Nucleotide Exchange Factors - genetics</topic><topic>Guanine Nucleotide Exchange Factors - metabolism</topic><topic>Guanosine triphosphatases</topic><topic>Humans</topic><topic>Lysosomes</topic><topic>Lysosomes - genetics</topic><topic>Lysosomes - metabolism</topic><topic>Maturation</topic><topic>Membrane trafficking</topic><topic>Membranes</topic><topic>Nucleotides</topic><topic>Organelle Biogenesis</topic><topic>Organelles</topic><topic>Principles</topic><topic>Protein transport</topic><topic>rab GTP-Binding Proteins - genetics</topic><topic>rab GTP-Binding Proteins - metabolism</topic><topic>rab5 GTP-Binding Proteins - genetics</topic><topic>rab5 GTP-Binding Proteins - metabolism</topic><topic>rab7 GTP-Binding Proteins</topic><topic>Recruitment</topic><topic>Review</topic><topic>Saccharomyces cerevisiae - genetics</topic><topic>Saccharomyces cerevisiae - metabolism</topic><topic>Saccharomyces cerevisiae Proteins - genetics</topic><topic>Saccharomyces cerevisiae Proteins - metabolism</topic><topic>Signal Transduction</topic><topic>Trafficking</topic><topic>Transport processes</topic><topic>Vesicular Transport Proteins - genetics</topic><topic>Vesicular Transport Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Borchers, Ann-Christin</creatorcontrib><creatorcontrib>Langemeyer, Lars</creatorcontrib><creatorcontrib>Ungermann, Christian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Borchers, Ann-Christin</au><au>Langemeyer, Lars</au><au>Ungermann, Christian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Who's in control? Principles of Rab GTPase activation in endolysosomal membrane trafficking and beyond</atitle><jtitle>The Journal of cell biology</jtitle><addtitle>J Cell Biol</addtitle><date>2021-09-06</date><risdate>2021</risdate><volume>220</volume><issue>9</issue><spage>1</spage><pages>1-</pages><issn>0021-9525</issn><eissn>1540-8140</eissn><abstract>The eukaryotic endomembrane system consists of multiple interconnected organelles. Rab GTPases are organelle-specific markers that give identity to these membranes by recruiting transport and trafficking proteins. During transport processes or along organelle maturation, one Rab is replaced by another, a process termed Rab cascade, which requires at its center a Rab-specific guanine nucleotide exchange factor (GEF). The endolysosomal system serves here as a prime example for a Rab cascade. Along with endosomal maturation, the endosomal Rab5 recruits and activates the Rab7-specific GEF Mon1-Ccz1, resulting in Rab7 activation on endosomes and subsequent fusion of endosomes with lysosomes. In this review, we focus on the current idea of Mon1-Ccz1 recruitment and activation in the endolysosomal and autophagic pathway. We compare identified principles to other GTPase cascades on endomembranes, highlight the importance of regulation, and evaluate in this context the strength and relevance of recent developments in in vitro analyses to understand the underlying foundation of organelle biogenesis and maturation.</abstract><cop>United States</cop><pub>Rockefeller University Press</pub><pmid>34383013</pmid><doi>10.1083/jcb.202105120</doi><orcidid>https://orcid.org/0000-0002-4309-0910</orcidid><orcidid>https://orcid.org/0000-0003-2466-0129</orcidid><orcidid>https://orcid.org/0000-0003-4331-8695</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Autophagosomes - genetics Autophagosomes - metabolism Biochemistry Biological Transport Cell Membrane - genetics Cell Membrane - metabolism Conserved Sequence Endosomes Endosomes - genetics Endosomes - metabolism Gene Expression Regulation Guanine Guanine nucleotide exchange factor Guanine Nucleotide Exchange Factors - genetics Guanine Nucleotide Exchange Factors - metabolism Guanosine triphosphatases Humans Lysosomes Lysosomes - genetics Lysosomes - metabolism Maturation Membrane trafficking Membranes Nucleotides Organelle Biogenesis Organelles Principles Protein transport rab GTP-Binding Proteins - genetics rab GTP-Binding Proteins - metabolism rab5 GTP-Binding Proteins - genetics rab5 GTP-Binding Proteins - metabolism rab7 GTP-Binding Proteins Recruitment Review Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Signal Transduction Trafficking Transport processes Vesicular Transport Proteins - genetics Vesicular Transport Proteins - metabolism |
| title | Who's in control? Principles of Rab GTPase activation in endolysosomal membrane trafficking and beyond |
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