Risk of COVID-19 death in cancer patients: an analysis from Guy’s Cancer Centre and King’s College Hospital in London
Background Using an updated dataset with more patients and extended follow-up, we further established cancer patient characteristics associated with COVID-19 death. Methods Data on all cancer patients with a positive reverse transcription-polymerase chain reaction swab for severe acute respiratory s...
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| Veröffentlicht in: | British journal of cancer 2021-09, Vol.125 (7), p.939-947 |
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| creator | Russell, Beth Moss, Charlotte L. Shah, Vallari Ko, Thinzar Ko Palmer, Kieran Sylva, Rushan George, Gincy Monroy-Iglesias, Maria J. Patten, Piers Ceesay, Muhammed Mansour Benjamin, Reuben Potter, Victoria Pagliuca, Antonio Papa, Sophie Irshad, Sheeba Ross, Paul Spicer, James Kordasti, Shahram Crawley, Danielle Wylie, Harriet Cahill, Fidelma Haire, Anna Zaki, Kamarul Sita-Lumsden, Ailsa Josephs, Debra Enting, Deborah Swampillai, Angela Sawyer, Elinor D’Souza, Andrea Gomberg, Simon Harrison, Claire Fields, Paul Wrench, David Rigg, Anne Sullivan, Richard Kulasekararaj, Austin Dolly, Saoirse Van Hemelrijck, Mieke |
| description | Background
Using an updated dataset with more patients and extended follow-up, we further established cancer patient characteristics associated with COVID-19 death.
Methods
Data on all cancer patients with a positive reverse transcription-polymerase chain reaction swab for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) at Guy’s Cancer Centre and King’s College Hospital between 29 February and 31 July 2020 was used. Cox proportional hazards regression was performed to identify which factors were associated with COVID-19 mortality.
Results
Three hundred and six SARS-CoV-2-positive cancer patients were included. Seventy-one had mild/moderate and 29% had severe COVID-19. Seventy-two patients died of COVID-19 (24%), of whom 35 died 2–5 years [2.81 (1.41–5.59)] or ≥5 years were associated with an increased mortality. Age >60 years and raised C-reactive protein (CRP) were also associated with COVID-19 death. Haematological cancer, a longer-established cancer diagnosis, dyspnoea at diagnosis and raised CRP were indicative of early COVID-19-related death in cancer patients (2 years. These factors should be accounted for when making clinical decisions for cancer patients. |
| doi_str_mv | 10.1038/s41416-021-01500-z |
| format | Article |
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Using an updated dataset with more patients and extended follow-up, we further established cancer patient characteristics associated with COVID-19 death.
Methods
Data on all cancer patients with a positive reverse transcription-polymerase chain reaction swab for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) at Guy’s Cancer Centre and King’s College Hospital between 29 February and 31 July 2020 was used. Cox proportional hazards regression was performed to identify which factors were associated with COVID-19 mortality.
Results
Three hundred and six SARS-CoV-2-positive cancer patients were included. Seventy-one had mild/moderate and 29% had severe COVID-19. Seventy-two patients died of COVID-19 (24%), of whom 35 died <7 days. Male sex [hazard ratio (HR): 1.97 (95% confidence interval (CI): 1.15–3.38)], Asian ethnicity [3.42 (1. 59–7.35)], haematological cancer [2.03 (1.16–3.56)] and a cancer diagnosis for >2–5 years [2.81 (1.41–5.59)] or ≥5 years were associated with an increased mortality. Age >60 years and raised C-reactive protein (CRP) were also associated with COVID-19 death. Haematological cancer, a longer-established cancer diagnosis, dyspnoea at diagnosis and raised CRP were indicative of early COVID-19-related death in cancer patients (<7 days from diagnosis).
Conclusions
Findings further substantiate evidence for increased risk of COVID-19 mortality for male and Asian cancer patients, and those with haematological malignancies or a cancer diagnosis >2 years. These factors should be accounted for when making clinical decisions for cancer patients.</description><identifier>ISSN: 0007-0920</identifier><identifier>ISSN: 1532-1827</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/s41416-021-01500-z</identifier><identifier>PMID: 34400804</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/308/575 ; 692/4028 ; 692/499 ; Adult ; Aged ; Aged, 80 and over ; Biomedical and Life Sciences ; Biomedicine ; C-reactive protein ; Cancer ; Cancer Research ; Coronaviruses ; COVID-19 ; COVID-19 - complications ; COVID-19 - epidemiology ; COVID-19 - pathology ; COVID-19 - virology ; Death ; Diagnosis ; Drug Resistance ; Dyspnea ; Epidemiology ; Female ; Hematologic Neoplasms - complications ; Hematologic Neoplasms - epidemiology ; Hematologic Neoplasms - pathology ; Hematologic Neoplasms - virology ; Hematology ; Hospitals ; Humans ; London - epidemiology ; Male ; Medical diagnosis ; Middle Aged ; Molecular Medicine ; Mortality ; Neoplasms - complications ; Neoplasms - epidemiology ; Neoplasms - pathology ; Neoplasms - virology ; Oncology ; Patients ; Polymerase chain reaction ; Respiration ; Reverse transcription ; Risk Factors ; SARS-CoV-2 - pathogenicity ; Severe acute respiratory syndrome coronavirus 2 ; Sex ratio</subject><ispartof>British journal of cancer, 2021-09, Vol.125 (7), p.939-947</ispartof><rights>The Author(s) 2021</rights><rights>2021. The Author(s).</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-e47ce7cecf050eba21f09731497d2492f29cd8f4167a1d0ef9c06ed340808fc23</citedby><cites>FETCH-LOGICAL-c474t-e47ce7cecf050eba21f09731497d2492f29cd8f4167a1d0ef9c06ed340808fc23</cites><orcidid>0000-0002-2390-1886 ; 0000-0003-3320-3034 ; 0000-0002-9063-7675 ; 0000-0001-8285-4111 ; 0000-0001-5640-8425 ; 0000-0002-4419-7162</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8366163/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8366163/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,27907,27908,41471,42540,51302,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34400804$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Russell, Beth</creatorcontrib><creatorcontrib>Moss, Charlotte L.</creatorcontrib><creatorcontrib>Shah, Vallari</creatorcontrib><creatorcontrib>Ko, Thinzar Ko</creatorcontrib><creatorcontrib>Palmer, Kieran</creatorcontrib><creatorcontrib>Sylva, Rushan</creatorcontrib><creatorcontrib>George, Gincy</creatorcontrib><creatorcontrib>Monroy-Iglesias, Maria J.</creatorcontrib><creatorcontrib>Patten, Piers</creatorcontrib><creatorcontrib>Ceesay, Muhammed Mansour</creatorcontrib><creatorcontrib>Benjamin, Reuben</creatorcontrib><creatorcontrib>Potter, Victoria</creatorcontrib><creatorcontrib>Pagliuca, Antonio</creatorcontrib><creatorcontrib>Papa, Sophie</creatorcontrib><creatorcontrib>Irshad, Sheeba</creatorcontrib><creatorcontrib>Ross, Paul</creatorcontrib><creatorcontrib>Spicer, James</creatorcontrib><creatorcontrib>Kordasti, Shahram</creatorcontrib><creatorcontrib>Crawley, Danielle</creatorcontrib><creatorcontrib>Wylie, Harriet</creatorcontrib><creatorcontrib>Cahill, Fidelma</creatorcontrib><creatorcontrib>Haire, Anna</creatorcontrib><creatorcontrib>Zaki, Kamarul</creatorcontrib><creatorcontrib>Sita-Lumsden, Ailsa</creatorcontrib><creatorcontrib>Josephs, Debra</creatorcontrib><creatorcontrib>Enting, Deborah</creatorcontrib><creatorcontrib>Swampillai, Angela</creatorcontrib><creatorcontrib>Sawyer, Elinor</creatorcontrib><creatorcontrib>D’Souza, Andrea</creatorcontrib><creatorcontrib>Gomberg, Simon</creatorcontrib><creatorcontrib>Harrison, Claire</creatorcontrib><creatorcontrib>Fields, Paul</creatorcontrib><creatorcontrib>Wrench, David</creatorcontrib><creatorcontrib>Rigg, Anne</creatorcontrib><creatorcontrib>Sullivan, Richard</creatorcontrib><creatorcontrib>Kulasekararaj, Austin</creatorcontrib><creatorcontrib>Dolly, Saoirse</creatorcontrib><creatorcontrib>Van Hemelrijck, Mieke</creatorcontrib><creatorcontrib>Guy’s Cancer Real World Evidence</creatorcontrib><creatorcontrib>Guy’s Cancer Real World Evidence</creatorcontrib><title>Risk of COVID-19 death in cancer patients: an analysis from Guy’s Cancer Centre and King’s College Hospital in London</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Background
Using an updated dataset with more patients and extended follow-up, we further established cancer patient characteristics associated with COVID-19 death.
Methods
Data on all cancer patients with a positive reverse transcription-polymerase chain reaction swab for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) at Guy’s Cancer Centre and King’s College Hospital between 29 February and 31 July 2020 was used. Cox proportional hazards regression was performed to identify which factors were associated with COVID-19 mortality.
Results
Three hundred and six SARS-CoV-2-positive cancer patients were included. Seventy-one had mild/moderate and 29% had severe COVID-19. Seventy-two patients died of COVID-19 (24%), of whom 35 died <7 days. Male sex [hazard ratio (HR): 1.97 (95% confidence interval (CI): 1.15–3.38)], Asian ethnicity [3.42 (1. 59–7.35)], haematological cancer [2.03 (1.16–3.56)] and a cancer diagnosis for >2–5 years [2.81 (1.41–5.59)] or ≥5 years were associated with an increased mortality. Age >60 years and raised C-reactive protein (CRP) were also associated with COVID-19 death. Haematological cancer, a longer-established cancer diagnosis, dyspnoea at diagnosis and raised CRP were indicative of early COVID-19-related death in cancer patients (<7 days from diagnosis).
Conclusions
Findings further substantiate evidence for increased risk of COVID-19 mortality for male and Asian cancer patients, and those with haematological malignancies or a cancer diagnosis >2 years. These factors should be accounted for when making clinical decisions for cancer patients.</description><subject>692/308/575</subject><subject>692/4028</subject><subject>692/499</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>C-reactive protein</subject><subject>Cancer</subject><subject>Cancer Research</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - complications</subject><subject>COVID-19 - epidemiology</subject><subject>COVID-19 - pathology</subject><subject>COVID-19 - virology</subject><subject>Death</subject><subject>Diagnosis</subject><subject>Drug Resistance</subject><subject>Dyspnea</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Hematologic Neoplasms - complications</subject><subject>Hematologic Neoplasms - epidemiology</subject><subject>Hematologic Neoplasms - pathology</subject><subject>Hematologic Neoplasms - virology</subject><subject>Hematology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>London - epidemiology</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Mortality</subject><subject>Neoplasms - complications</subject><subject>Neoplasms - epidemiology</subject><subject>Neoplasms - pathology</subject><subject>Neoplasms - virology</subject><subject>Oncology</subject><subject>Patients</subject><subject>Polymerase chain reaction</subject><subject>Respiration</subject><subject>Reverse transcription</subject><subject>Risk Factors</subject><subject>SARS-CoV-2 - pathogenicity</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Sex 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of COVID-19 death in cancer patients: an analysis from Guy’s Cancer Centre and King’s College Hospital in London</title><author>Russell, Beth ; Moss, Charlotte L. ; Shah, Vallari ; Ko, Thinzar Ko ; Palmer, Kieran ; Sylva, Rushan ; George, Gincy ; Monroy-Iglesias, Maria J. ; Patten, Piers ; Ceesay, Muhammed Mansour ; Benjamin, Reuben ; Potter, Victoria ; Pagliuca, Antonio ; Papa, Sophie ; Irshad, Sheeba ; Ross, Paul ; Spicer, James ; Kordasti, Shahram ; Crawley, Danielle ; Wylie, Harriet ; Cahill, Fidelma ; Haire, Anna ; Zaki, Kamarul ; Sita-Lumsden, Ailsa ; Josephs, Debra ; Enting, Deborah ; Swampillai, Angela ; Sawyer, Elinor ; D’Souza, Andrea ; Gomberg, Simon ; Harrison, Claire ; Fields, Paul ; Wrench, David ; Rigg, Anne ; Sullivan, Richard ; Kulasekararaj, Austin ; Dolly, Saoirse ; Van Hemelrijck, 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Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Russell, Beth</au><au>Moss, Charlotte L.</au><au>Shah, Vallari</au><au>Ko, Thinzar Ko</au><au>Palmer, Kieran</au><au>Sylva, Rushan</au><au>George, Gincy</au><au>Monroy-Iglesias, Maria J.</au><au>Patten, Piers</au><au>Ceesay, Muhammed Mansour</au><au>Benjamin, Reuben</au><au>Potter, Victoria</au><au>Pagliuca, Antonio</au><au>Papa, Sophie</au><au>Irshad, Sheeba</au><au>Ross, Paul</au><au>Spicer, James</au><au>Kordasti, Shahram</au><au>Crawley, Danielle</au><au>Wylie, Harriet</au><au>Cahill, Fidelma</au><au>Haire, Anna</au><au>Zaki, Kamarul</au><au>Sita-Lumsden, Ailsa</au><au>Josephs, Debra</au><au>Enting, Deborah</au><au>Swampillai, Angela</au><au>Sawyer, Elinor</au><au>D’Souza, Andrea</au><au>Gomberg, Simon</au><au>Harrison, Claire</au><au>Fields, Paul</au><au>Wrench, David</au><au>Rigg, Anne</au><au>Sullivan, Richard</au><au>Kulasekararaj, Austin</au><au>Dolly, Saoirse</au><au>Van Hemelrijck, Mieke</au><aucorp>Guy’s Cancer Real World Evidence</aucorp><aucorp>Guy’s Cancer Real World Evidence</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk of COVID-19 death in cancer patients: an analysis from Guy’s Cancer Centre and King’s College Hospital in London</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2021-09-28</date><risdate>2021</risdate><volume>125</volume><issue>7</issue><spage>939</spage><epage>947</epage><pages>939-947</pages><issn>0007-0920</issn><issn>1532-1827</issn><eissn>1532-1827</eissn><abstract>Background
Using an updated dataset with more patients and extended follow-up, we further established cancer patient characteristics associated with COVID-19 death.
Methods
Data on all cancer patients with a positive reverse transcription-polymerase chain reaction swab for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) at Guy’s Cancer Centre and King’s College Hospital between 29 February and 31 July 2020 was used. Cox proportional hazards regression was performed to identify which factors were associated with COVID-19 mortality.
Results
Three hundred and six SARS-CoV-2-positive cancer patients were included. Seventy-one had mild/moderate and 29% had severe COVID-19. Seventy-two patients died of COVID-19 (24%), of whom 35 died <7 days. Male sex [hazard ratio (HR): 1.97 (95% confidence interval (CI): 1.15–3.38)], Asian ethnicity [3.42 (1. 59–7.35)], haematological cancer [2.03 (1.16–3.56)] and a cancer diagnosis for >2–5 years [2.81 (1.41–5.59)] or ≥5 years were associated with an increased mortality. Age >60 years and raised C-reactive protein (CRP) were also associated with COVID-19 death. Haematological cancer, a longer-established cancer diagnosis, dyspnoea at diagnosis and raised CRP were indicative of early COVID-19-related death in cancer patients (<7 days from diagnosis).
Conclusions
Findings further substantiate evidence for increased risk of COVID-19 mortality for male and Asian cancer patients, and those with haematological malignancies or a cancer diagnosis >2 years. These factors should be accounted for when making clinical decisions for cancer patients.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>34400804</pmid><doi>10.1038/s41416-021-01500-z</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-2390-1886</orcidid><orcidid>https://orcid.org/0000-0003-3320-3034</orcidid><orcidid>https://orcid.org/0000-0002-9063-7675</orcidid><orcidid>https://orcid.org/0000-0001-8285-4111</orcidid><orcidid>https://orcid.org/0000-0001-5640-8425</orcidid><orcidid>https://orcid.org/0000-0002-4419-7162</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-0920 |
| ispartof | British journal of cancer, 2021-09, Vol.125 (7), p.939-947 |
| issn | 0007-0920 1532-1827 1532-1827 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8366163 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | 692/308/575 692/4028 692/499 Adult Aged Aged, 80 and over Biomedical and Life Sciences Biomedicine C-reactive protein Cancer Cancer Research Coronaviruses COVID-19 COVID-19 - complications COVID-19 - epidemiology COVID-19 - pathology COVID-19 - virology Death Diagnosis Drug Resistance Dyspnea Epidemiology Female Hematologic Neoplasms - complications Hematologic Neoplasms - epidemiology Hematologic Neoplasms - pathology Hematologic Neoplasms - virology Hematology Hospitals Humans London - epidemiology Male Medical diagnosis Middle Aged Molecular Medicine Mortality Neoplasms - complications Neoplasms - epidemiology Neoplasms - pathology Neoplasms - virology Oncology Patients Polymerase chain reaction Respiration Reverse transcription Risk Factors SARS-CoV-2 - pathogenicity Severe acute respiratory syndrome coronavirus 2 Sex ratio |
| title | Risk of COVID-19 death in cancer patients: an analysis from Guy’s Cancer Centre and King’s College Hospital in London |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T18%3A02%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Risk%20of%20COVID-19%20death%20in%20cancer%20patients:%20an%20analysis%20from%20Guy%E2%80%99s%20Cancer%20Centre%20and%20King%E2%80%99s%20College%20Hospital%20in%20London&rft.jtitle=British%20journal%20of%20cancer&rft.au=Russell,%20Beth&rft.aucorp=Guy%E2%80%99s%20Cancer%20Real%20World%20Evidence&rft.date=2021-09-28&rft.volume=125&rft.issue=7&rft.spage=939&rft.epage=947&rft.pages=939-947&rft.issn=0007-0920&rft.eissn=1532-1827&rft_id=info:doi/10.1038/s41416-021-01500-z&rft_dat=%3Cproquest_pubme%3E2562237168%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2576737119&rft_id=info:pmid/34400804&rfr_iscdi=true |