Retinal vascular abnormalities in different types of inherited retinal dystrophies assessed by optical coherence tomography angiography
Purpose: To investigate the retinal vascular characteristics among patients with different types of inherited retinal dystrophies (IRDs). Methods: This comparative cross-sectional study was conducted on 59 genetically confirmed cases of IRD including 37 patients with retinitis pigmentosa (RP) (74 ey...
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| Veröffentlicht in: | Iranian journal of ophthalmology 2021-04, Vol.33 (2), p.189-196 |
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| creator | Sabbaghi, Hamideh Daftarian, Narsis Hassanpour, Kiana Fekri, Sahba Nourinia, Ramin Suri, Fatemeh Kheiri, Bahareh Yaseri, Mehdi Rajabpour, Mojtaba Sheibani, Kourosh Ahmadieh, Hamid |
| description | Purpose: To investigate the retinal vascular characteristics among patients with different types of inherited retinal dystrophies (IRDs).
Methods: This comparative cross-sectional study was conducted on 59 genetically confirmed cases of IRD including 37 patients with retinitis pigmentosa (RP) (74 eyes), 13 patients with Stargardt disease (STGD) (26 eyes), and 9 patients with cone-rod dystrophy (CRD) (18 eyes). Both eyes of 50 age- and sex-matched healthy individuals were investigated as controls. All participants underwent optical coherence tomography angiography to investigate the vascular densities (VDs) of superficial and deep capillary plexus (SCP and DCP) as well as foveal avascular zone area.
Results: In RP, significantly lower VD in whole image (P = 0.001 for DCP), fovea (P = 0.038 for SCP), parafovea (P < 0.001 for SCP and DCP), and perifovea (P < 0.001 for SCP and DCP) was observed compared to controls. In STGD, VD of parafovea (P = 0.012 for SCP and P = 0.001 for DCP) and fovea (P = 0.016 for DCP) was significantly lower than controls. In CRD, the VD of parafovea (P = 0.025 for DCP) was significantly lower than controls. Whole image density was significantly lower in RP compared to STGD (P < 0.001 for SCP) and CRD (P = 0.037 for SCP). VD in parafovea (P = 0.005 for SCP) and perifovea (P < 0.001 for SCP and DCP) regions was significantly lower in RP compared with STGD. Also, foveal VD in STGD was significantly lower than RP (P = 0.023 for DCP).
Conclusion: Our study demonstrated lower VDs in three different IRDs including RP, STGD, and CRD compared to healthy controls. Changes were more dominant in RP patients. |
| doi_str_mv | 10.4103/joco.joco_11_21 |
| format | Article |
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Methods: This comparative cross-sectional study was conducted on 59 genetically confirmed cases of IRD including 37 patients with retinitis pigmentosa (RP) (74 eyes), 13 patients with Stargardt disease (STGD) (26 eyes), and 9 patients with cone-rod dystrophy (CRD) (18 eyes). Both eyes of 50 age- and sex-matched healthy individuals were investigated as controls. All participants underwent optical coherence tomography angiography to investigate the vascular densities (VDs) of superficial and deep capillary plexus (SCP and DCP) as well as foveal avascular zone area.
Results: In RP, significantly lower VD in whole image (P = 0.001 for DCP), fovea (P = 0.038 for SCP), parafovea (P < 0.001 for SCP and DCP), and perifovea (P < 0.001 for SCP and DCP) was observed compared to controls. In STGD, VD of parafovea (P = 0.012 for SCP and P = 0.001 for DCP) and fovea (P = 0.016 for DCP) was significantly lower than controls. In CRD, the VD of parafovea (P = 0.025 for DCP) was significantly lower than controls. Whole image density was significantly lower in RP compared to STGD (P < 0.001 for SCP) and CRD (P = 0.037 for SCP). VD in parafovea (P = 0.005 for SCP) and perifovea (P < 0.001 for SCP and DCP) regions was significantly lower in RP compared with STGD. Also, foveal VD in STGD was significantly lower than RP (P = 0.023 for DCP).
Conclusion: Our study demonstrated lower VDs in three different IRDs including RP, STGD, and CRD compared to healthy controls. Changes were more dominant in RP patients.</description><identifier>ISSN: 2452-2325</identifier><identifier>EISSN: 2452-2325</identifier><identifier>DOI: 10.4103/joco.joco_11_21</identifier><identifier>PMID: 34409231</identifier><language>eng</language><publisher>Tehran: Wolters Kluwer India Pvt. Ltd</publisher><subject>Angiography ; Medical imaging ; Medical research ; Medicine, Experimental ; Original ; Tomography</subject><ispartof>Iranian journal of ophthalmology, 2021-04, Vol.33 (2), p.189-196</ispartof><rights>COPYRIGHT 2021 Medknow Publications and Media Pvt. Ltd.</rights><rights>2021. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright: © 2021 Journal of Current Ophthalmology 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c531r-747054e240ae288a86e765e353f291844a4542c498c1f2f2b6fa18d2d413f81e3</citedby><cites>FETCH-LOGICAL-c531r-747054e240ae288a86e765e353f291844a4542c498c1f2f2b6fa18d2d413f81e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365577/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365577/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,27460,27926,27927,53793,53795</link.rule.ids></links><search><creatorcontrib>Sabbaghi, Hamideh</creatorcontrib><creatorcontrib>Daftarian, Narsis</creatorcontrib><creatorcontrib>Hassanpour, Kiana</creatorcontrib><creatorcontrib>Fekri, Sahba</creatorcontrib><creatorcontrib>Nourinia, Ramin</creatorcontrib><creatorcontrib>Suri, Fatemeh</creatorcontrib><creatorcontrib>Kheiri, Bahareh</creatorcontrib><creatorcontrib>Yaseri, Mehdi</creatorcontrib><creatorcontrib>Rajabpour, Mojtaba</creatorcontrib><creatorcontrib>Sheibani, Kourosh</creatorcontrib><creatorcontrib>Ahmadieh, Hamid</creatorcontrib><title>Retinal vascular abnormalities in different types of inherited retinal dystrophies assessed by optical coherence tomography angiography</title><title>Iranian journal of ophthalmology</title><description>Purpose: To investigate the retinal vascular characteristics among patients with different types of inherited retinal dystrophies (IRDs).
Methods: This comparative cross-sectional study was conducted on 59 genetically confirmed cases of IRD including 37 patients with retinitis pigmentosa (RP) (74 eyes), 13 patients with Stargardt disease (STGD) (26 eyes), and 9 patients with cone-rod dystrophy (CRD) (18 eyes). Both eyes of 50 age- and sex-matched healthy individuals were investigated as controls. All participants underwent optical coherence tomography angiography to investigate the vascular densities (VDs) of superficial and deep capillary plexus (SCP and DCP) as well as foveal avascular zone area.
Results: In RP, significantly lower VD in whole image (P = 0.001 for DCP), fovea (P = 0.038 for SCP), parafovea (P < 0.001 for SCP and DCP), and perifovea (P < 0.001 for SCP and DCP) was observed compared to controls. In STGD, VD of parafovea (P = 0.012 for SCP and P = 0.001 for DCP) and fovea (P = 0.016 for DCP) was significantly lower than controls. In CRD, the VD of parafovea (P = 0.025 for DCP) was significantly lower than controls. Whole image density was significantly lower in RP compared to STGD (P < 0.001 for SCP) and CRD (P = 0.037 for SCP). VD in parafovea (P = 0.005 for SCP) and perifovea (P < 0.001 for SCP and DCP) regions was significantly lower in RP compared with STGD. Also, foveal VD in STGD was significantly lower than RP (P = 0.023 for DCP).
Conclusion: Our study demonstrated lower VDs in three different IRDs including RP, STGD, and CRD compared to healthy controls. Changes were more dominant in RP patients.</description><subject>Angiography</subject><subject>Medical imaging</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Original</subject><subject>Tomography</subject><issn>2452-2325</issn><issn>2452-2325</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1Uk1r3DAQNaWlCWnOvRp66WU3-rZ8KYTQtIFAobRnoZVHa21sy5XkLPsL-rcrZ52mKS0SmmHmvSdmeEXxFqM1w4he7Lzx6_lRGCuCXxSnhHGyIpTwl3_kJ8V5jDuEEBYcY4ZeFyeUMVQTik-Ln18huUF35b2OZup0KPVm8KHXnUsOYumGsnHWQoAhlekw5pK3udpCcAmaMiz05hBT8GM7c3SMkG9Tbg6lH5MzuW98O2sYKJPv_TbosT2Ueti6JX9TvLK6i3C-xLPi-_XHb1efV7dfPt1cXd6uDKc4rCpWIc6AMKSBSKmlgEpwoJxaUmPJmGacEcNqabAllmyE1Vg2pGGYWomBnhUfjrrjtOmhMXmsoDs1BtfrcFBeO_W8M7hWbf29klRwXlVZ4P0iEPyPCWJSvYsGuk4P4KeoCBdEUopqmqHv_oLu_BTytmYUR5wQXssn1FZ3oNxgff7XzKLqUghJhKhqnlHrf6DyaaB3xg9gXa4_I1wcCSb4GAPY3zNipGb7qAfnPNknM26OjL3vEoR41017CCrv4m7w-__RFJa1WkykHk1EfwFJcdXB</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Sabbaghi, Hamideh</creator><creator>Daftarian, Narsis</creator><creator>Hassanpour, Kiana</creator><creator>Fekri, Sahba</creator><creator>Nourinia, Ramin</creator><creator>Suri, Fatemeh</creator><creator>Kheiri, Bahareh</creator><creator>Yaseri, Mehdi</creator><creator>Rajabpour, Mojtaba</creator><creator>Sheibani, Kourosh</creator><creator>Ahmadieh, Hamid</creator><general>Wolters Kluwer India Pvt. 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Methods: This comparative cross-sectional study was conducted on 59 genetically confirmed cases of IRD including 37 patients with retinitis pigmentosa (RP) (74 eyes), 13 patients with Stargardt disease (STGD) (26 eyes), and 9 patients with cone-rod dystrophy (CRD) (18 eyes). Both eyes of 50 age- and sex-matched healthy individuals were investigated as controls. All participants underwent optical coherence tomography angiography to investigate the vascular densities (VDs) of superficial and deep capillary plexus (SCP and DCP) as well as foveal avascular zone area.
Results: In RP, significantly lower VD in whole image (P = 0.001 for DCP), fovea (P = 0.038 for SCP), parafovea (P < 0.001 for SCP and DCP), and perifovea (P < 0.001 for SCP and DCP) was observed compared to controls. In STGD, VD of parafovea (P = 0.012 for SCP and P = 0.001 for DCP) and fovea (P = 0.016 for DCP) was significantly lower than controls. In CRD, the VD of parafovea (P = 0.025 for DCP) was significantly lower than controls. Whole image density was significantly lower in RP compared to STGD (P < 0.001 for SCP) and CRD (P = 0.037 for SCP). VD in parafovea (P = 0.005 for SCP) and perifovea (P < 0.001 for SCP and DCP) regions was significantly lower in RP compared with STGD. Also, foveal VD in STGD was significantly lower than RP (P = 0.023 for DCP).
Conclusion: Our study demonstrated lower VDs in three different IRDs including RP, STGD, and CRD compared to healthy controls. Changes were more dominant in RP patients.</abstract><cop>Tehran</cop><pub>Wolters Kluwer India Pvt. Ltd</pub><pmid>34409231</pmid><doi>10.4103/joco.joco_11_21</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Angiography Medical imaging Medical research Medicine, Experimental Original Tomography |
| title | Retinal vascular abnormalities in different types of inherited retinal dystrophies assessed by optical coherence tomography angiography |
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