Alarmin S100A9 restricts retroviral infection by limiting reverse transcription in human dendritic cells

Dendritic cells (DC) subsets, like Langerhans cells (LC), are immune cells involved in pathogen sensing. They express specific antimicrobial cellular factors that are able to restrict infection and limit further pathogen transmission. Here, we identify the alarmin S100A9 as a novel intracellular ant...

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Veröffentlicht in:	The EMBO journal 2021-08, Vol.40 (16), p.e106540-n/a
Hauptverfasser:	Maarifi, Ghizlane, Lagisquet, Justine, Hertel, Quentin, Bonaventure, Boris, Chamontin, Célia, Fuchs, Kyra, Moncorgé, Olivier, Tauziet, Marine, Mombled, Margaux, Papin, Laure, Molès, Jean‐Pierre, Bodet, Charles, Lévèque, Nicolas, Gross, Antoine, Arhel, Nathalie, Nisole, Sébastien, Van de Perre, Philippe, Goujon, Caroline, Blanchet, Fabien P
Format:	Artikel
Sprache:	eng
Schlagworte:	Alarmins / genetics Animals Antiinfectives and antibacterials Antiretroviral agents Antiviral activity Calgranulin B / genetics Cations CD4-Positive T-Lymphocytes / immunology Cell Line Cell lines Chelation Cricetulus Dendritic cells Divalent cations Ectopic expression EMBO19 EMBO23 HIV HIV-1 / genetics HIV-1 / physiology HIV‐1 Host-Pathogen Interactions Human health and pathology Human immunodeficiency virus Humans Immune system Immunology Infections Infectious diseases Innate immunity Intracellular Langerhans cells Langerhans Cells / immunology Langerhans Cells / virology Leukemia, Experimental / prevention & control Life Sciences Localization Magnesium Mice Microbiology and Parasitology Moloney murine leukemia virus / genetics Moloney murine leukemia virus / physiology Monocytes Pathogens Retroviridae Infections / prevention & control Reverse Transcription RNA-directed DNA polymerase S100A9 Transforming Growth Factor beta / immunology Tumor Virus Infections / prevention & control Uncoating viral restriction Virology Virus Replication
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