Novel molecular targeted therapies for patients with neurofibromatosis type 1 with inoperable plexiform neurofibromas: a comprehensive review

Neurofibromatosis type 1 (NF1) is a genetic disorder that carries a higher risk of tumor development. Plexiform neurofibromas (PNs) are present in 50% of NF1 and cause significant morbidity when surgery is not feasible. Systemic therapies had not succeeded to reduce PN tumor volume until 2016 when t...

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Veröffentlicht in:	ESMO open 2021-08, Vol.6 (4), p.100223, Article 100223
Hauptverfasser:	Solares, I., Viñal, D., Morales-Conejo, M., Rodriguez-Salas, N., Feliu, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Child Humans Molecular Targeted Therapy neoplasms Neurofibroma, Plexiform - drug therapy Neurofibromatosis 1 - complications Neurofibromatosis 1 - drug therapy Neurofibromatosis 1 - genetics neurofibromatosis type 1 plexiform neurofibromas Protein Kinase Inhibitors - adverse effects Review Tumor Burden
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