Inflammatory cytokines TNF-α and IL-17 enhance the efficacy of cystic fibrosis transmembrane conductance regulator modulators

Without cystic fibrosis transmembrane conductance regulator-mediated (CFTR-mediated) HCO3- secretion, airway epithelia of newborns with cystic fibrosis (CF) produce an abnormally acidic airway surface liquid (ASL), and the decreased pH impairs respiratory host defenses. However, within a few months...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of clinical investigation 2021-08, Vol.131 (16), p.1-11
Hauptverfasser:	Rehman, Tayyab, Karp, Philip H, Tan, Ping, Goodell, Brian J, Pezzulo, Alejandro A, Thurman, Andrew L, Thornell, Ian M, Durfey, Samantha L, Duffey, Michael E, Stoltz, David A, McKone, Edward F, Singh, Pradeep K, Welsh, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Aminophenols - administration & dosage Benzodioxoles - administration & dosage Bicarbonates - metabolism Biomedical research Birth Cells, Cultured Chlorides Cystic fibrosis Cystic Fibrosis - drug therapy Cystic Fibrosis - immunology Cystic Fibrosis - physiopathology Cystic Fibrosis Transmembrane Conductance Regulator - drug effects Cystic Fibrosis Transmembrane Conductance Regulator - genetics Cystic Fibrosis Transmembrane Conductance Regulator - metabolism Cytokines Drug Combinations Gene expression Humans Hydrogen-Ion Concentration Hypotheses Indoles - administration & dosage Infant Infant, Newborn Inflammation Interleukin 17 Interleukin-17 - administration & dosage Interleukin-17 - metabolism Ion Transport Mutation Neonates pH effects Pyrazoles - administration & dosage Pyridines - administration & dosage Quinolines - administration & dosage Respiratory function Respiratory Mucosa - drug effects Respiratory Mucosa - immunology Respiratory Mucosa - metabolism Respiratory tract Respiratory tract diseases Sulfate Transporters - genetics Sulfate Transporters - metabolism Tumor Necrosis Factor-alpha - administration & dosage Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!