Butyryl/Caproyl-CoA:Acetate CoA-transferase: cloning, expression and characterization of the key enzyme involved in medium-chain fatty acid biosynthesis

Coenzyme A transferases (CoATs) are important enzymes involved in carbon chain elongation, contributing to medium-chain fatty acid (MCFA) biosynthesis. For example, butyryl-CoA:acetate CoA transferase (BCoAT) is responsible for the final step of butyrate synthesis from butyryl-CoA. However, little i...

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Veröffentlicht in:	Bioscience reports 2021-08, Vol.41 (8)
Hauptverfasser:	Yang, Qingzhuoma, Guo, Shengtao, Lu, Qi, Tao, Yong, Zheng, Decong, Zhou, Qinmao, Liu, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Acyl Coenzyme A - metabolism Bacteria Bacterial Proteins - genetics Bacterial Proteins - metabolism Bioinformatics Biosynthesis Butyrates - metabolism Caproates - metabolism Cloning Cloning, Molecular Clostridium tyrobutyricum - enzymology Clostridium tyrobutyricum - genetics CoA transferase Coenzyme A Coenzyme A-Transferases - chemistry Coenzyme A-Transferases - genetics Coenzyme A-Transferases - metabolism Conserved sequence Dehydrogenases E coli Elongation Enzymatic activity Enzymes Escherichia coli - enzymology Escherichia coli - genetics Fatty acids Gene expression Genes Hexanoic acid Kinetics Microbiology Models, Molecular Molecular chains Mutation Oxidation Oxidation-Reduction Phylogeny Plasmids Potassium Protein Conformation Proteins Raw materials Structure-Activity Relationship Substrate Specificity Substrates
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