Potential association of prolonged patient interval and advanced anatomic stage in breast cancer patients in the area affected by the 2011 triple disaster in Fukushima, Japan: Retrospective observational study
For five years after the 2011 triple disaster (earthquake, tsunami, and nuclear disaster) in Japan, the proportion of patients with undiagnosed symptomatic breast cancer remained elevated in the coastal area of Fukushima. These individuals experienced a prolonged interval from first symptom recognit...
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| Veröffentlicht in: | Medicine (Baltimore) 2021-08, Vol.100 (32), p.e26830-e26830 |
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| creator | Ozaki, Akihiko Toyoaki, Sawano Tsukada, Manabu Shimada, Yuki Kawamoto, Ayumu Wang, Ji-Wei Bhandari, Divya Tsubokura, Masaharu Ohira, Hiromichi |
| description | For five years after the 2011 triple disaster (earthquake, tsunami, and nuclear disaster) in Japan, the proportion of patients with undiagnosed symptomatic breast cancer remained elevated in the coastal area of Fukushima. These individuals experienced a prolonged interval from first symptom recognition to initial medical consultation (hereafter referred to as the patient interval). We aimed to investigate how this prolonged patient interval affected disease staging.Using patient records, we retrospectively extracted females with newly and pathologically diagnosed breast cancer who initially presented to Minamisoma Municipal General Hospital from March 2011 to March 2016. We estimated the proportion with advanced-stage disease (III, IV) according to the patient interval duration ( |
| doi_str_mv | 10.1097/MD.0000000000026830 |
| format | Article |
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These individuals experienced a prolonged interval from first symptom recognition to initial medical consultation (hereafter referred to as the patient interval). We aimed to investigate how this prolonged patient interval affected disease staging.Using patient records, we retrospectively extracted females with newly and pathologically diagnosed breast cancer who initially presented to Minamisoma Municipal General Hospital from March 2011 to March 2016. We estimated the proportion with advanced-stage disease (III, IV) according to the patient interval duration (<3 months, 3-12 months, and 12 months plus). A cut-off patient interval value was determined based on the previous evidence with regards to impacts on survival prospects. Logistic regression approaches were used to fulfill the study outcome.The proportion of patients with advanced-stage disease was 10.3% for < 3 months (7/68), 18.2% for 3-12 months (2/11), and 66.7% for more than 12 months (12/18). We found a similar trend using the multivariate logistic regression analyses.Prolongation of the patient interval was associated with advanced-stage disease among female patients with breast cancer.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000026830</identifier><identifier>PMID: 34397887</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins</publisher><subject>Breast Neoplasms - diagnosis ; Breast Neoplasms - epidemiology ; Breast Neoplasms - etiology ; Disasters ; Female ; Fukushima Nuclear Accident ; Humans ; Incidence ; Japan - epidemiology ; Middle Aged ; Neoplasm Staging ; Observational Study ; Retrospective Studies ; Stress, Psychological - complications ; Stress, Psychological - diagnosis ; Time Factors</subject><ispartof>Medicine (Baltimore), 2021-08, Vol.100 (32), p.e26830-e26830</ispartof><rights>Lippincott Williams & Wilkins</rights><rights>Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3551-ac7eae94c2c26fe26cba20ba2835a37b293dc930281de198967cb638a03e96d53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360466/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360466/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34397887$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ozaki, Akihiko</creatorcontrib><creatorcontrib>Toyoaki, Sawano</creatorcontrib><creatorcontrib>Tsukada, Manabu</creatorcontrib><creatorcontrib>Shimada, Yuki</creatorcontrib><creatorcontrib>Kawamoto, Ayumu</creatorcontrib><creatorcontrib>Wang, Ji-Wei</creatorcontrib><creatorcontrib>Bhandari, Divya</creatorcontrib><creatorcontrib>Tsubokura, Masaharu</creatorcontrib><creatorcontrib>Ohira, Hiromichi</creatorcontrib><title>Potential association of prolonged patient interval and advanced anatomic stage in breast cancer patients in the area affected by the 2011 triple disaster in Fukushima, Japan: Retrospective observational study</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>For five years after the 2011 triple disaster (earthquake, tsunami, and nuclear disaster) in Japan, the proportion of patients with undiagnosed symptomatic breast cancer remained elevated in the coastal area of Fukushima. These individuals experienced a prolonged interval from first symptom recognition to initial medical consultation (hereafter referred to as the patient interval). We aimed to investigate how this prolonged patient interval affected disease staging.Using patient records, we retrospectively extracted females with newly and pathologically diagnosed breast cancer who initially presented to Minamisoma Municipal General Hospital from March 2011 to March 2016. We estimated the proportion with advanced-stage disease (III, IV) according to the patient interval duration (<3 months, 3-12 months, and 12 months plus). A cut-off patient interval value was determined based on the previous evidence with regards to impacts on survival prospects. Logistic regression approaches were used to fulfill the study outcome.The proportion of patients with advanced-stage disease was 10.3% for < 3 months (7/68), 18.2% for 3-12 months (2/11), and 66.7% for more than 12 months (12/18). We found a similar trend using the multivariate logistic regression analyses.Prolongation of the patient interval was associated with advanced-stage disease among female patients with breast cancer.</description><subject>Breast Neoplasms - diagnosis</subject><subject>Breast Neoplasms - epidemiology</subject><subject>Breast Neoplasms - etiology</subject><subject>Disasters</subject><subject>Female</subject><subject>Fukushima Nuclear Accident</subject><subject>Humans</subject><subject>Incidence</subject><subject>Japan - epidemiology</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Observational Study</subject><subject>Retrospective Studies</subject><subject>Stress, Psychological - complications</subject><subject>Stress, Psychological - diagnosis</subject><subject>Time Factors</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUttu1DAQjRCILoUvQEJ-5IEUXxIn5gEJtZSLWoEQPFsTZ7Ixzcap7Wy1n9k_qtNty8WSZWnOxWfsybKXjB4xqqq35ydH9M_ishb0UbZipZB5qWTxOFulaplXqioOsmch_KaUiYoXT7MDUQhV1XW1yq6_u4hjtDAQCMEZC9G6kbiOTN4NblxjS6ZUSxxix4h-uzDHlkC7hdEkFEaIbmMNCRHWmEik8QghErPg_l4dFiT2SCChBLoOTUzqZndb5JQxEr2dBiStDUmelElwOl_MobcbeEO-wgTjO_IDo3dhSmq7ReKasERaMqdcIc7t7nn2pIMh4Iu78zD7dfrx5_Hn_Ozbpy_HH85yI8qS5WAqBFSF4YbLDrk0DXCadi1KEFXDlWiNEpTXrEWmaiUr00hRAxWoZFuKw-z93neamw22JvXoYdCTT2n9Tjuw-l9ktL1eu62uhaSFlMng9Z2Bd5czhqg3NhgcBhjRzUHzUjLFC1HzRBV7qkm9B4_dwzWM6mUY9PmJ_n8YkurV3wkfNPe_nwjFnnDlhvTg4WKYr9DrHmGI_a1fWSmec8oZrZmg-WLNxA0R8cU1</recordid><startdate>20210813</startdate><enddate>20210813</enddate><creator>Ozaki, Akihiko</creator><creator>Toyoaki, Sawano</creator><creator>Tsukada, Manabu</creator><creator>Shimada, Yuki</creator><creator>Kawamoto, Ayumu</creator><creator>Wang, Ji-Wei</creator><creator>Bhandari, Divya</creator><creator>Tsubokura, Masaharu</creator><creator>Ohira, Hiromichi</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210813</creationdate><title>Potential association of prolonged patient interval and advanced anatomic stage in breast cancer patients in the area affected by the 2011 triple disaster in Fukushima, Japan: Retrospective observational study</title><author>Ozaki, Akihiko ; Toyoaki, Sawano ; Tsukada, Manabu ; Shimada, Yuki ; Kawamoto, Ayumu ; Wang, Ji-Wei ; Bhandari, Divya ; Tsubokura, Masaharu ; Ohira, Hiromichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3551-ac7eae94c2c26fe26cba20ba2835a37b293dc930281de198967cb638a03e96d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Breast Neoplasms - diagnosis</topic><topic>Breast Neoplasms - epidemiology</topic><topic>Breast Neoplasms - etiology</topic><topic>Disasters</topic><topic>Female</topic><topic>Fukushima Nuclear Accident</topic><topic>Humans</topic><topic>Incidence</topic><topic>Japan - epidemiology</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Observational Study</topic><topic>Retrospective Studies</topic><topic>Stress, Psychological - complications</topic><topic>Stress, Psychological - diagnosis</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ozaki, Akihiko</creatorcontrib><creatorcontrib>Toyoaki, Sawano</creatorcontrib><creatorcontrib>Tsukada, Manabu</creatorcontrib><creatorcontrib>Shimada, Yuki</creatorcontrib><creatorcontrib>Kawamoto, Ayumu</creatorcontrib><creatorcontrib>Wang, Ji-Wei</creatorcontrib><creatorcontrib>Bhandari, Divya</creatorcontrib><creatorcontrib>Tsubokura, Masaharu</creatorcontrib><creatorcontrib>Ohira, Hiromichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ozaki, Akihiko</au><au>Toyoaki, Sawano</au><au>Tsukada, Manabu</au><au>Shimada, Yuki</au><au>Kawamoto, Ayumu</au><au>Wang, Ji-Wei</au><au>Bhandari, Divya</au><au>Tsubokura, Masaharu</au><au>Ohira, Hiromichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potential association of prolonged patient interval and advanced anatomic stage in breast cancer patients in the area affected by the 2011 triple disaster in Fukushima, Japan: Retrospective observational study</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2021-08-13</date><risdate>2021</risdate><volume>100</volume><issue>32</issue><spage>e26830</spage><epage>e26830</epage><pages>e26830-e26830</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>For five years after the 2011 triple disaster (earthquake, tsunami, and nuclear disaster) in Japan, the proportion of patients with undiagnosed symptomatic breast cancer remained elevated in the coastal area of Fukushima. These individuals experienced a prolonged interval from first symptom recognition to initial medical consultation (hereafter referred to as the patient interval). We aimed to investigate how this prolonged patient interval affected disease staging.Using patient records, we retrospectively extracted females with newly and pathologically diagnosed breast cancer who initially presented to Minamisoma Municipal General Hospital from March 2011 to March 2016. We estimated the proportion with advanced-stage disease (III, IV) according to the patient interval duration (<3 months, 3-12 months, and 12 months plus). A cut-off patient interval value was determined based on the previous evidence with regards to impacts on survival prospects. Logistic regression approaches were used to fulfill the study outcome.The proportion of patients with advanced-stage disease was 10.3% for < 3 months (7/68), 18.2% for 3-12 months (2/11), and 66.7% for more than 12 months (12/18). We found a similar trend using the multivariate logistic regression analyses.Prolongation of the patient interval was associated with advanced-stage disease among female patients with breast cancer.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins</pub><pmid>34397887</pmid><doi>10.1097/MD.0000000000026830</doi><oa>free_for_read</oa></addata></record> |
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| source | Wolters Kluwer Open Health; MEDLINE; DOAJ Directory of Open Access Journals; IngentaConnect Free/Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Breast Neoplasms - diagnosis Breast Neoplasms - epidemiology Breast Neoplasms - etiology Disasters Female Fukushima Nuclear Accident Humans Incidence Japan - epidemiology Middle Aged Neoplasm Staging Observational Study Retrospective Studies Stress, Psychological - complications Stress, Psychological - diagnosis Time Factors |
| title | Potential association of prolonged patient interval and advanced anatomic stage in breast cancer patients in the area affected by the 2011 triple disaster in Fukushima, Japan: Retrospective observational study |
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