Binding Mode Characterization of Osteopontin on Hydroxyapatite by Solution NMR Spectroscopy

Extracellular matrix glycoproteins play a major role in bone mineralization and modulation of osteogenesis. Among these, the intrinsically disordered protein osteopontin (OPN) is associated with the inhibition of formation, growth and proliferation of the bone mineral hydroxyapatite (HAP). Furthermo...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2021-07, Vol.22 (13), p.2300-2305
Hauptverfasser:	Holzinger, Julian, Kotisch, Harald, Richter, Klaus W., Konrat, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Binding Sites Biomedical materials biomineralization Durapatite - chemistry Extracellular matrix Glycoproteins Hydroxyapatite intrinsically disordered protein Magnetic Resonance Spectroscopy Mineralization Nanoparticles NMR NMR spectroscopy Nuclear magnetic resonance Osteogenesis Osteopontin Osteopontin - chemistry Phosphorylation Proteins Solutions Spectroscopy Spectrum analysis Surface Properties
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