Ajuba transactivates N‐cadherin expression in colorectal cancer cells through interaction with Twist

Ajuba is a multiple LIM domain‐containing protein and functions as a transcriptional coregulator to modulate many gene expressions in various cellular processes. Here, we describe that the LIM domain of Ajuba interacts with Twist, and the Twist box is a pivotal motif for the interaction. Biologicall...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2021-08, Vol.25 (16), p.8006-8014
Hauptverfasser:	Wu, Zhaoxia, Zou, Xiuqun, Xu, Ying, Zhou, Fengli, Kuai, Rong, Li, Ji, Yang, Daming, Chu, Yimin, Peng, Haixia
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Ajuba Antibodies Antigens, CD - metabolism Cadherins Cadherins - metabolism Cancer Cell Line, Tumor Chromatin Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Experiments Gene Expression Regulation Histones Humans Immunoprecipitation LIM domain LIM Domain Proteins - metabolism Metastases Metastasis Nuclear Proteins - metabolism Original p300/CBP Peptide Fragments - metabolism Plasmids Promoter Regions, Genetic Protein Interaction Domains and Motifs Proteins Reagents Sialoglycoproteins - metabolism Statistical analysis Transcription Tumors Twist Twist-Related Protein 1 - metabolism
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