Regulation of adipose tissue inflammation and systemic metabolism in murine obesity by polymer implants loaded with lentiviral vectors encoding human interleukin‐4

Dysfunctional adipose tissue plays a central role in the pathogenesis of the obesity‐related metabolic disease, including type 2 diabetes. Targeting adipose tissue using biopolymer implants is a novel therapeutic approach for metabolic disease. We transplanted porous poly(lactide‐co‐glycolide) (PLG)...

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Veröffentlicht in:	Biotechnology and bioengineering 2020-12, Vol.117 (12), p.3891-3901
Hauptverfasser:	Youngblood, Richard, Flesher, Carmen G., Delproposto, Jennifer, Baker, Nicki A., Neeley, Christopher K., Li, Fanghua, Lumeng, Carey N., Shea, Lonnie D., O'Rourke, Robert W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Adipose Tissue - metabolism Animal tissues Animals biomaterial Biomaterials Biomedical materials Biopolymers CD3 antigen CD4 antigen Cytokines Diabetes mellitus (non-insulin dependent) Diet Disease Models, Animal Flow cytometry Glucose Glucose tolerance High fat diet Histology Humans Hypertrophy Immunohistochemistry Immunological tolerance Implants, Experimental In vivo methods and tests Inflammation Inflammation - genetics Inflammation - metabolism insulin resistance Interleukin-4 - biosynthesis Interleukin-4 - genetics Interleukins Lentivirus Male Metabolic disorders Mice Obesity Obesity - genetics Obesity - metabolism Pathogenesis poly(lactide‐co‐glycolide) Polymerase chain reaction Polymers Surgical implants Transduction, Genetic
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