Construction of a Potentially Functional circRNA-miRNA-mRNA Network in Intervertebral Disc Degeneration by Bioinformatics Analysis
Background. The competing endogenous RNA- (ceRNA-) mediated regulatory mechanisms are known to play a pivotal role in intervertebral disc degeneration (IDD). Our research intended to establish a ceRNA regulatory network related to IDD through bioinformatics analyses. Methods. The expression profiles...
Gespeichert in:
| Veröffentlicht in: | BioMed research international 2021-08, Vol.2021, p.1-21 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 21 |
|---|---|
| container_issue | |
| container_start_page | 1 |
| container_title | BioMed research international |
| container_volume | 2021 |
| creator | Huo, Zhenxin Li, Hao Tian, Lijun Li, Jianhua Zhang, Kaihui Li, Zhenhua Li, Guowang Du, Lilong Xu, Haiwei Xu, Baoshan |
| description | Background. The competing endogenous RNA- (ceRNA-) mediated regulatory mechanisms are known to play a pivotal role in intervertebral disc degeneration (IDD). Our research intended to establish a ceRNA regulatory network related to IDD through bioinformatics analyses. Methods. The expression profiles of circRNA, miRNA, and mRNA were obtained from the public Gene Expression Omnibus (GEO) datasets. Then, we use sequence-based bioinformatics methods to select differentially expressed mRNAs (DEmRNAs), microRNAs (DEmiRNAs), or circRNAs (DEcircRNAs) related to IDD. We used ChEA3 to verify the targets of transcription factors (TFs). Then, we used DAVID to annotate the DEmRNAs. Finally, we constructed a potentially circRNA-miRNA-mRNA network related to IDD by predicting in the database (ENCORI, TargetScan, miRecords, miRmap, and circBank). Results. We identified 31 common DEmRNAs by Venn analysis, of which MMP2 was regarded as the key hub genes. Simultaneously, miR-423-5p and miR-185-5p were predicted as the upstream molecules of MMP2. Furthermore, a total of six DEcircRNAs were predicted as the upstream circRNAs of miR-423-5p and miR-185-5p. Then, a potential circRNA-miRNA-mRNA network related to IDD was constructed by bioinformatics analysis. Conclusion. A comprehensive ceRNA regulatory network was constructed, which was found to be significant in IDD progression. |
| doi_str_mv | 10.1155/2021/8352683 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8357516</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A696875014</galeid><sourcerecordid>A696875014</sourcerecordid><originalsourceid>FETCH-LOGICAL-c481t-1b6f5e579fd8fccb494876e087a2aa71c5a3be3575059132411e9cba8ac8d3f53</originalsourceid><addsrcrecordid>eNp9kk1v1DAQhi0EolXpjR9giQsShMafcS5Iy5ZCpaogBGfL8U62Lond2k6rvfLLcXZXK8GhPowt-9E7844Hodek_kCIEGe0puRMMUGlYs_QMWWEV5Jw8vxwZuwInaZ0W5eliKxb-RIdMc5aIak4Rn-WwaccJ5td8Dj02ODvIYPPzgzDBl9MfvtiBmxdtD-uF9XotrEEfA35McTf2Hl86TPEB4gZuljgc5csPoc1eIhmK91t8CcXnO9DHMuNTXhRVDfJpVfoRW-GBKf7_QT9uvj8c_m1uvr25XK5uKosVyRXpJO9ANG0_Ur11na85aqRUKvGUGMaYoVhHTDRiFq0hFFOCLS2M8pYtWK9YCfo4073bupGWNlispSq76IbTdzoYJz-98W7G70OD1rNokQWgbd7gRjuJ0hZj8UmDIPxEKakqZCkpXOfC_rmP_Q2TLEY3lGMKl5-5kCtzQB67k3Ja2dRvZCtVMUK4U9Tc22FmTO-31E2hpQi9AdjpNbzrOh5VvR-Vgr-boffOL8yj-5p-i_wdbu7</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2561328413</pqid></control><display><type>article</type><title>Construction of a Potentially Functional circRNA-miRNA-mRNA Network in Intervertebral Disc Degeneration by Bioinformatics Analysis</title><source>Wiley_OA刊</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>PubMed Central Open Access</source><creator>Huo, Zhenxin ; Li, Hao ; Tian, Lijun ; Li, Jianhua ; Zhang, Kaihui ; Li, Zhenhua ; Li, Guowang ; Du, Lilong ; Xu, Haiwei ; Xu, Baoshan</creator><contributor>Li, Pei ; Pei Li</contributor><creatorcontrib>Huo, Zhenxin ; Li, Hao ; Tian, Lijun ; Li, Jianhua ; Zhang, Kaihui ; Li, Zhenhua ; Li, Guowang ; Du, Lilong ; Xu, Haiwei ; Xu, Baoshan ; Li, Pei ; Pei Li</creatorcontrib><description>Background. The competing endogenous RNA- (ceRNA-) mediated regulatory mechanisms are known to play a pivotal role in intervertebral disc degeneration (IDD). Our research intended to establish a ceRNA regulatory network related to IDD through bioinformatics analyses. Methods. The expression profiles of circRNA, miRNA, and mRNA were obtained from the public Gene Expression Omnibus (GEO) datasets. Then, we use sequence-based bioinformatics methods to select differentially expressed mRNAs (DEmRNAs), microRNAs (DEmiRNAs), or circRNAs (DEcircRNAs) related to IDD. We used ChEA3 to verify the targets of transcription factors (TFs). Then, we used DAVID to annotate the DEmRNAs. Finally, we constructed a potentially circRNA-miRNA-mRNA network related to IDD by predicting in the database (ENCORI, TargetScan, miRecords, miRmap, and circBank). Results. We identified 31 common DEmRNAs by Venn analysis, of which MMP2 was regarded as the key hub genes. Simultaneously, miR-423-5p and miR-185-5p were predicted as the upstream molecules of MMP2. Furthermore, a total of six DEcircRNAs were predicted as the upstream circRNAs of miR-423-5p and miR-185-5p. Then, a potential circRNA-miRNA-mRNA network related to IDD was constructed by bioinformatics analysis. Conclusion. A comprehensive ceRNA regulatory network was constructed, which was found to be significant in IDD progression.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2021/8352683</identifier><identifier>PMID: 34395625</identifier><language>eng</language><publisher>New York: Hindawi</publisher><subject>Analysis ; Bioinformatics ; Care and treatment ; Causes of ; Chromosome 5 ; Computational biology ; Datasets ; Degeneration ; Degenerative disc disease ; Diagnosis ; Gelatinase A ; Gene expression ; Genetic aspects ; Hernia ; Identification and classification ; Intervertebral discs ; Intervertebral disk ; Intervertebral disk displacement ; Low back pain ; Methods ; miRNA ; Pathogenesis ; Physiological aspects ; Proteins ; Regulatory mechanisms (biology) ; Ribonucleic acid ; Risk factors ; RNA ; Software ; Transcription factors ; Web sites</subject><ispartof>BioMed research international, 2021-08, Vol.2021, p.1-21</ispartof><rights>Copyright © 2021 Zhenxin Huo et al.</rights><rights>COPYRIGHT 2021 John Wiley & Sons, Inc.</rights><rights>Copyright © 2021 Zhenxin Huo et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2021 Zhenxin Huo et al. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-1b6f5e579fd8fccb494876e087a2aa71c5a3be3575059132411e9cba8ac8d3f53</citedby><cites>FETCH-LOGICAL-c481t-1b6f5e579fd8fccb494876e087a2aa71c5a3be3575059132411e9cba8ac8d3f53</cites><orcidid>0000-0002-4407-8745</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357516/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357516/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids></links><search><contributor>Li, Pei</contributor><contributor>Pei Li</contributor><creatorcontrib>Huo, Zhenxin</creatorcontrib><creatorcontrib>Li, Hao</creatorcontrib><creatorcontrib>Tian, Lijun</creatorcontrib><creatorcontrib>Li, Jianhua</creatorcontrib><creatorcontrib>Zhang, Kaihui</creatorcontrib><creatorcontrib>Li, Zhenhua</creatorcontrib><creatorcontrib>Li, Guowang</creatorcontrib><creatorcontrib>Du, Lilong</creatorcontrib><creatorcontrib>Xu, Haiwei</creatorcontrib><creatorcontrib>Xu, Baoshan</creatorcontrib><title>Construction of a Potentially Functional circRNA-miRNA-mRNA Network in Intervertebral Disc Degeneration by Bioinformatics Analysis</title><title>BioMed research international</title><description>Background. The competing endogenous RNA- (ceRNA-) mediated regulatory mechanisms are known to play a pivotal role in intervertebral disc degeneration (IDD). Our research intended to establish a ceRNA regulatory network related to IDD through bioinformatics analyses. Methods. The expression profiles of circRNA, miRNA, and mRNA were obtained from the public Gene Expression Omnibus (GEO) datasets. Then, we use sequence-based bioinformatics methods to select differentially expressed mRNAs (DEmRNAs), microRNAs (DEmiRNAs), or circRNAs (DEcircRNAs) related to IDD. We used ChEA3 to verify the targets of transcription factors (TFs). Then, we used DAVID to annotate the DEmRNAs. Finally, we constructed a potentially circRNA-miRNA-mRNA network related to IDD by predicting in the database (ENCORI, TargetScan, miRecords, miRmap, and circBank). Results. We identified 31 common DEmRNAs by Venn analysis, of which MMP2 was regarded as the key hub genes. Simultaneously, miR-423-5p and miR-185-5p were predicted as the upstream molecules of MMP2. Furthermore, a total of six DEcircRNAs were predicted as the upstream circRNAs of miR-423-5p and miR-185-5p. Then, a potential circRNA-miRNA-mRNA network related to IDD was constructed by bioinformatics analysis. Conclusion. A comprehensive ceRNA regulatory network was constructed, which was found to be significant in IDD progression.</description><subject>Analysis</subject><subject>Bioinformatics</subject><subject>Care and treatment</subject><subject>Causes of</subject><subject>Chromosome 5</subject><subject>Computational biology</subject><subject>Datasets</subject><subject>Degeneration</subject><subject>Degenerative disc disease</subject><subject>Diagnosis</subject><subject>Gelatinase A</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Hernia</subject><subject>Identification and classification</subject><subject>Intervertebral discs</subject><subject>Intervertebral disk</subject><subject>Intervertebral disk displacement</subject><subject>Low back pain</subject><subject>Methods</subject><subject>miRNA</subject><subject>Pathogenesis</subject><subject>Physiological aspects</subject><subject>Proteins</subject><subject>Regulatory mechanisms (biology)</subject><subject>Ribonucleic acid</subject><subject>Risk factors</subject><subject>RNA</subject><subject>Software</subject><subject>Transcription factors</subject><subject>Web sites</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kk1v1DAQhi0EolXpjR9giQsShMafcS5Iy5ZCpaogBGfL8U62Lond2k6rvfLLcXZXK8GhPowt-9E7844Hodek_kCIEGe0puRMMUGlYs_QMWWEV5Jw8vxwZuwInaZ0W5eliKxb-RIdMc5aIak4Rn-WwaccJ5td8Dj02ODvIYPPzgzDBl9MfvtiBmxdtD-uF9XotrEEfA35McTf2Hl86TPEB4gZuljgc5csPoc1eIhmK91t8CcXnO9DHMuNTXhRVDfJpVfoRW-GBKf7_QT9uvj8c_m1uvr25XK5uKosVyRXpJO9ANG0_Ur11na85aqRUKvGUGMaYoVhHTDRiFq0hFFOCLS2M8pYtWK9YCfo4073bupGWNlispSq76IbTdzoYJz-98W7G70OD1rNokQWgbd7gRjuJ0hZj8UmDIPxEKakqZCkpXOfC_rmP_Q2TLEY3lGMKl5-5kCtzQB67k3Ja2dRvZCtVMUK4U9Tc22FmTO-31E2hpQi9AdjpNbzrOh5VvR-Vgr-boffOL8yj-5p-i_wdbu7</recordid><startdate>20210804</startdate><enddate>20210804</enddate><creator>Huo, Zhenxin</creator><creator>Li, Hao</creator><creator>Tian, Lijun</creator><creator>Li, Jianhua</creator><creator>Zhang, Kaihui</creator><creator>Li, Zhenhua</creator><creator>Li, Guowang</creator><creator>Du, Lilong</creator><creator>Xu, Haiwei</creator><creator>Xu, Baoshan</creator><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4407-8745</orcidid></search><sort><creationdate>20210804</creationdate><title>Construction of a Potentially Functional circRNA-miRNA-mRNA Network in Intervertebral Disc Degeneration by Bioinformatics Analysis</title><author>Huo, Zhenxin ; Li, Hao ; Tian, Lijun ; Li, Jianhua ; Zhang, Kaihui ; Li, Zhenhua ; Li, Guowang ; Du, Lilong ; Xu, Haiwei ; Xu, Baoshan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-1b6f5e579fd8fccb494876e087a2aa71c5a3be3575059132411e9cba8ac8d3f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Analysis</topic><topic>Bioinformatics</topic><topic>Care and treatment</topic><topic>Causes of</topic><topic>Chromosome 5</topic><topic>Computational biology</topic><topic>Datasets</topic><topic>Degeneration</topic><topic>Degenerative disc disease</topic><topic>Diagnosis</topic><topic>Gelatinase A</topic><topic>Gene expression</topic><topic>Genetic aspects</topic><topic>Hernia</topic><topic>Identification and classification</topic><topic>Intervertebral discs</topic><topic>Intervertebral disk</topic><topic>Intervertebral disk displacement</topic><topic>Low back pain</topic><topic>Methods</topic><topic>miRNA</topic><topic>Pathogenesis</topic><topic>Physiological aspects</topic><topic>Proteins</topic><topic>Regulatory mechanisms (biology)</topic><topic>Ribonucleic acid</topic><topic>Risk factors</topic><topic>RNA</topic><topic>Software</topic><topic>Transcription factors</topic><topic>Web sites</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huo, Zhenxin</creatorcontrib><creatorcontrib>Li, Hao</creatorcontrib><creatorcontrib>Tian, Lijun</creatorcontrib><creatorcontrib>Li, Jianhua</creatorcontrib><creatorcontrib>Zhang, Kaihui</creatorcontrib><creatorcontrib>Li, Zhenhua</creatorcontrib><creatorcontrib>Li, Guowang</creatorcontrib><creatorcontrib>Du, Lilong</creatorcontrib><creatorcontrib>Xu, Haiwei</creatorcontrib><creatorcontrib>Xu, Baoshan</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest advanced technologies & aerospace journals</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huo, Zhenxin</au><au>Li, Hao</au><au>Tian, Lijun</au><au>Li, Jianhua</au><au>Zhang, Kaihui</au><au>Li, Zhenhua</au><au>Li, Guowang</au><au>Du, Lilong</au><au>Xu, Haiwei</au><au>Xu, Baoshan</au><au>Li, Pei</au><au>Pei Li</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Construction of a Potentially Functional circRNA-miRNA-mRNA Network in Intervertebral Disc Degeneration by Bioinformatics Analysis</atitle><jtitle>BioMed research international</jtitle><date>2021-08-04</date><risdate>2021</risdate><volume>2021</volume><spage>1</spage><epage>21</epage><pages>1-21</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Background. The competing endogenous RNA- (ceRNA-) mediated regulatory mechanisms are known to play a pivotal role in intervertebral disc degeneration (IDD). Our research intended to establish a ceRNA regulatory network related to IDD through bioinformatics analyses. Methods. The expression profiles of circRNA, miRNA, and mRNA were obtained from the public Gene Expression Omnibus (GEO) datasets. Then, we use sequence-based bioinformatics methods to select differentially expressed mRNAs (DEmRNAs), microRNAs (DEmiRNAs), or circRNAs (DEcircRNAs) related to IDD. We used ChEA3 to verify the targets of transcription factors (TFs). Then, we used DAVID to annotate the DEmRNAs. Finally, we constructed a potentially circRNA-miRNA-mRNA network related to IDD by predicting in the database (ENCORI, TargetScan, miRecords, miRmap, and circBank). Results. We identified 31 common DEmRNAs by Venn analysis, of which MMP2 was regarded as the key hub genes. Simultaneously, miR-423-5p and miR-185-5p were predicted as the upstream molecules of MMP2. Furthermore, a total of six DEcircRNAs were predicted as the upstream circRNAs of miR-423-5p and miR-185-5p. Then, a potential circRNA-miRNA-mRNA network related to IDD was constructed by bioinformatics analysis. Conclusion. A comprehensive ceRNA regulatory network was constructed, which was found to be significant in IDD progression.</abstract><cop>New York</cop><pub>Hindawi</pub><pmid>34395625</pmid><doi>10.1155/2021/8352683</doi><tpages>21</tpages><orcidid>https://orcid.org/0000-0002-4407-8745</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2314-6133 |
| ispartof | BioMed research international, 2021-08, Vol.2021, p.1-21 |
| issn | 2314-6133 2314-6141 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8357516 |
| source | Wiley_OA刊; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Analysis Bioinformatics Care and treatment Causes of Chromosome 5 Computational biology Datasets Degeneration Degenerative disc disease Diagnosis Gelatinase A Gene expression Genetic aspects Hernia Identification and classification Intervertebral discs Intervertebral disk Intervertebral disk displacement Low back pain Methods miRNA Pathogenesis Physiological aspects Proteins Regulatory mechanisms (biology) Ribonucleic acid Risk factors RNA Software Transcription factors Web sites |
| title | Construction of a Potentially Functional circRNA-miRNA-mRNA Network in Intervertebral Disc Degeneration by Bioinformatics Analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T06%3A27%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Construction%20of%20a%20Potentially%20Functional%20circRNA-miRNA-mRNA%20Network%20in%20Intervertebral%20Disc%20Degeneration%20by%20Bioinformatics%20Analysis&rft.jtitle=BioMed%20research%20international&rft.au=Huo,%20Zhenxin&rft.date=2021-08-04&rft.volume=2021&rft.spage=1&rft.epage=21&rft.pages=1-21&rft.issn=2314-6133&rft.eissn=2314-6141&rft_id=info:doi/10.1155/2021/8352683&rft_dat=%3Cgale_pubme%3EA696875014%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2561328413&rft_id=info:pmid/34395625&rft_galeid=A696875014&rfr_iscdi=true |