Selection Approach to Identify the Optimal Biomarker Using Quantitative Muscle MRI and Functional Assessments in Becker Muscular Dystrophy

To identify the best quantitative fat-water MRI biomarker for disease progression of leg muscles in Becker muscular dystrophy (BMD) by applying a stepwise approach based on standardized response mean (SRM) over 24 months, correlations with baseline ambulatory tests, and reproducibility. Dixon fat-wa...

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Veröffentlicht in:	Neurology 2021-08, Vol.97 (5), p.e513-e522
Hauptverfasser:	van de Velde, Nienke M., Hooijmans, Melissa T., Sardjoe Mishre, Aashley S.D., Keene, Kevin R., Koeks, Zaïda, Veeger, Thom T.J., Alleman, Iris, van Zwet, Erik W., Beenakker, Jan-Willem M., Verschuuren, Jan J.G.M., Kan, Hermien E., Niks, Erik H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - diagnostic imaging Adult Biomarkers - analysis Disease Progression Female Follow-Up Studies Humans Leg - diagnostic imaging Leg - physiopathology Magnetic Resonance Imaging Male Middle Aged Muscle Contraction Muscle, Skeletal - diagnostic imaging Muscle, Skeletal - physiopathology Muscular Dystrophy, Duchenne - diagnosis Muscular Dystrophy, Duchenne - diagnostic imaging Muscular Dystrophy, Duchenne - physiopathology Observer Variation Reproducibility of Results Thigh Walk Test Young Adult
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