Exploring the Pharmacological Mechanism of Liuwei Dihuang Decoction for Diabetic Retinopathy: A Systematic Biological Strategy-Based Research
Objective. To explore the pharmacological mechanism of Liuwei Dihuang decoction (LDD) for diabetic retinopathy (DR). Methods. The potential targets of LDD were predicted by PharmMapper. GeneCards and other databases were used to collect DR genes. Cytoscape was used to construct and analyze network D...
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| creator | Yuan, Mengxia He, Qi Long, Zhiyong Zhu, Xiaofei Xiang, Wang Wu, Yonghe Lin, Shibin |
| description | Objective. To explore the pharmacological mechanism of Liuwei Dihuang decoction (LDD) for diabetic retinopathy (DR). Methods. The potential targets of LDD were predicted by PharmMapper. GeneCards and other databases were used to collect DR genes. Cytoscape was used to construct and analyze network DR and LDD’s network, and DAVID was used for Gene Ontology (GO) and pathway enrichment analysis. Finally, animal experiments were carried out to verify the results of systematic pharmacology. Results. Five networks were constructed and analyzed: (1) diabetic retinopathy genes’ PPI network; (2) compound-compound target network of LDD; (3) LDD-DR PPI network; (4) compound-known target network of LDD; (5) LDD known target-DR PPI network. Several DR and treatment-related targets, clusters, signaling pathways, and biological processes were found. Animal experiments found that LDD can improve the histopathological changes of the retina. LDD can also increase erythrocyte filtration rate and decrease the platelet adhesion rate (P |
| doi_str_mv | 10.1155/2021/5544518 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8356007</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2561920765</sourcerecordid><originalsourceid>FETCH-LOGICAL-c448t-ce37c900b998487ba4be9c4fa403d472c8c551563b0e9384898d7957e7c2d8e93</originalsourceid><addsrcrecordid>eNp9kU1v1DAQhi0EomXhxhlZ4lIJ0tqxvbY5IPULirQIREHiZjnOZOMqibd2QtkfwX_Gyy4r4MDFtmYev5rRg9BTSo4pFeKkJCU9EYJzQdU9dEglpwUvlbq_f8uvB-hRSjeElFpK-RAdMM40Z4odoh-X31ddiH5Y4rEF_LG1sbcudGHpne3we3CtHXzqcWjwwk934PGFbyeb-QtwwY0-DLgJMVdtBaN3-FM-h7CyY7t-hU_x9TqN0NtN58zvc6_HaEdYroszm6DOfxLY6NrH6EFjuwRPdvcMfXlz-fn8qlh8ePvu_HRROM7VWDhg0mlCKq0VV7KyvALteGM5YTWXpVNOCCrmrCKgWUa0qqUWEqQra5VLM_R6m7uaqh5qB0OepzOr6Hsb1yZYb_7uDL41y_DNKCbmhMgccLQLiOF2gjSa3icHXWcHCFMypZhTXRI5Fxl9_g96E6Y45PV-UaxUGxMz9HJLuRhSitDsh6HEbDybjWez85zxZ38usId_i83Aiy3Q-qG2d_7_cT8Ba8uxzw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2561328438</pqid></control><display><type>article</type><title>Exploring the Pharmacological Mechanism of Liuwei Dihuang Decoction for Diabetic Retinopathy: A Systematic Biological Strategy-Based Research</title><source>Wiley Online Library Open Access</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>PubMed Central Open Access</source><creator>Yuan, Mengxia ; He, Qi ; Long, Zhiyong ; Zhu, Xiaofei ; Xiang, Wang ; Wu, Yonghe ; Lin, Shibin</creator><contributor>Kuan, Yu Hsiang ; Yu Hsiang Kuan</contributor><creatorcontrib>Yuan, Mengxia ; He, Qi ; Long, Zhiyong ; Zhu, Xiaofei ; Xiang, Wang ; Wu, Yonghe ; Lin, Shibin ; Kuan, Yu Hsiang ; Yu Hsiang Kuan</creatorcontrib><description>Objective. To explore the pharmacological mechanism of Liuwei Dihuang decoction (LDD) for diabetic retinopathy (DR). Methods. The potential targets of LDD were predicted by PharmMapper. GeneCards and other databases were used to collect DR genes. Cytoscape was used to construct and analyze network DR and LDD’s network, and DAVID was used for Gene Ontology (GO) and pathway enrichment analysis. Finally, animal experiments were carried out to verify the results of systematic pharmacology. Results. Five networks were constructed and analyzed: (1) diabetic retinopathy genes’ PPI network; (2) compound-compound target network of LDD; (3) LDD-DR PPI network; (4) compound-known target network of LDD; (5) LDD known target-DR PPI network. Several DR and treatment-related targets, clusters, signaling pathways, and biological processes were found. Animal experiments found that LDD can improve the histopathological changes of the retina. LDD can also increase erythrocyte filtration rate and decrease the platelet adhesion rate (P<0.05) and decrease MDA and TXB2 (P<0.05). Compared with the model group, the retinal VEGF and HIF-1α expression in the LDD group decreased significantly (P<0.05). Conclusion. The therapeutic effect of LDD on DR may be achieved by interfering with the biological processes (such as response to insulin, glucose homeostasis, and regulation of angiogenesis) and signaling pathways (such as insulin, VEGF, HIF-1, and ErbB signaling pathway) related to the development of DR that was found in this research.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2021/5544518</identifier><identifier>PMID: 34394383</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Angiogenesis ; Animal research ; Chinese medicine ; Diabetes ; Diabetes mellitus ; Diabetic retinopathy ; Drug dosages ; Edema ; ErbB protein ; Glucose ; Homeostasis ; Hypoxia-inducible factor 1a ; Insulin ; Retina ; Retinopathy ; Signal transduction ; Vascular endothelial growth factor ; Visual impairment</subject><ispartof>Evidence-based complementary and alternative medicine, 2021, Vol.2021, p.5544518-20</ispartof><rights>Copyright © 2021 Mengxia Yuan et al.</rights><rights>Copyright © 2021 Mengxia Yuan et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2021 Mengxia Yuan et al. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-ce37c900b998487ba4be9c4fa403d472c8c551563b0e9384898d7957e7c2d8e93</citedby><cites>FETCH-LOGICAL-c448t-ce37c900b998487ba4be9c4fa403d472c8c551563b0e9384898d7957e7c2d8e93</cites><orcidid>0000-0002-3243-8002 ; 0000-0002-7307-0566</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8356007/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8356007/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34394383$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Kuan, Yu Hsiang</contributor><contributor>Yu Hsiang Kuan</contributor><creatorcontrib>Yuan, Mengxia</creatorcontrib><creatorcontrib>He, Qi</creatorcontrib><creatorcontrib>Long, Zhiyong</creatorcontrib><creatorcontrib>Zhu, Xiaofei</creatorcontrib><creatorcontrib>Xiang, Wang</creatorcontrib><creatorcontrib>Wu, Yonghe</creatorcontrib><creatorcontrib>Lin, Shibin</creatorcontrib><title>Exploring the Pharmacological Mechanism of Liuwei Dihuang Decoction for Diabetic Retinopathy: A Systematic Biological Strategy-Based Research</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Objective. To explore the pharmacological mechanism of Liuwei Dihuang decoction (LDD) for diabetic retinopathy (DR). Methods. The potential targets of LDD were predicted by PharmMapper. GeneCards and other databases were used to collect DR genes. Cytoscape was used to construct and analyze network DR and LDD’s network, and DAVID was used for Gene Ontology (GO) and pathway enrichment analysis. Finally, animal experiments were carried out to verify the results of systematic pharmacology. Results. Five networks were constructed and analyzed: (1) diabetic retinopathy genes’ PPI network; (2) compound-compound target network of LDD; (3) LDD-DR PPI network; (4) compound-known target network of LDD; (5) LDD known target-DR PPI network. Several DR and treatment-related targets, clusters, signaling pathways, and biological processes were found. Animal experiments found that LDD can improve the histopathological changes of the retina. LDD can also increase erythrocyte filtration rate and decrease the platelet adhesion rate (P<0.05) and decrease MDA and TXB2 (P<0.05). Compared with the model group, the retinal VEGF and HIF-1α expression in the LDD group decreased significantly (P<0.05). Conclusion. The therapeutic effect of LDD on DR may be achieved by interfering with the biological processes (such as response to insulin, glucose homeostasis, and regulation of angiogenesis) and signaling pathways (such as insulin, VEGF, HIF-1, and ErbB signaling pathway) related to the development of DR that was found in this research.</description><subject>Angiogenesis</subject><subject>Animal research</subject><subject>Chinese medicine</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetic retinopathy</subject><subject>Drug dosages</subject><subject>Edema</subject><subject>ErbB protein</subject><subject>Glucose</subject><subject>Homeostasis</subject><subject>Hypoxia-inducible factor 1a</subject><subject>Insulin</subject><subject>Retina</subject><subject>Retinopathy</subject><subject>Signal transduction</subject><subject>Vascular endothelial growth factor</subject><subject>Visual impairment</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kU1v1DAQhi0EomXhxhlZ4lIJ0tqxvbY5IPULirQIREHiZjnOZOMqibd2QtkfwX_Gyy4r4MDFtmYev5rRg9BTSo4pFeKkJCU9EYJzQdU9dEglpwUvlbq_f8uvB-hRSjeElFpK-RAdMM40Z4odoh-X31ddiH5Y4rEF_LG1sbcudGHpne3we3CtHXzqcWjwwk934PGFbyeb-QtwwY0-DLgJMVdtBaN3-FM-h7CyY7t-hU_x9TqN0NtN58zvc6_HaEdYroszm6DOfxLY6NrH6EFjuwRPdvcMfXlz-fn8qlh8ePvu_HRROM7VWDhg0mlCKq0VV7KyvALteGM5YTWXpVNOCCrmrCKgWUa0qqUWEqQra5VLM_R6m7uaqh5qB0OepzOr6Hsb1yZYb_7uDL41y_DNKCbmhMgccLQLiOF2gjSa3icHXWcHCFMypZhTXRI5Fxl9_g96E6Y45PV-UaxUGxMz9HJLuRhSitDsh6HEbDybjWez85zxZ38usId_i83Aiy3Q-qG2d_7_cT8Ba8uxzw</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Yuan, Mengxia</creator><creator>He, Qi</creator><creator>Long, Zhiyong</creator><creator>Zhu, Xiaofei</creator><creator>Xiang, Wang</creator><creator>Wu, Yonghe</creator><creator>Lin, Shibin</creator><general>Hindawi</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3243-8002</orcidid><orcidid>https://orcid.org/0000-0002-7307-0566</orcidid></search><sort><creationdate>2021</creationdate><title>Exploring the Pharmacological Mechanism of Liuwei Dihuang Decoction for Diabetic Retinopathy: A Systematic Biological Strategy-Based Research</title><author>Yuan, Mengxia ; He, Qi ; Long, Zhiyong ; Zhu, Xiaofei ; Xiang, Wang ; Wu, Yonghe ; Lin, Shibin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-ce37c900b998487ba4be9c4fa403d472c8c551563b0e9384898d7957e7c2d8e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Angiogenesis</topic><topic>Animal research</topic><topic>Chinese medicine</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetic retinopathy</topic><topic>Drug dosages</topic><topic>Edema</topic><topic>ErbB protein</topic><topic>Glucose</topic><topic>Homeostasis</topic><topic>Hypoxia-inducible factor 1a</topic><topic>Insulin</topic><topic>Retina</topic><topic>Retinopathy</topic><topic>Signal transduction</topic><topic>Vascular endothelial growth factor</topic><topic>Visual impairment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yuan, Mengxia</creatorcontrib><creatorcontrib>He, Qi</creatorcontrib><creatorcontrib>Long, Zhiyong</creatorcontrib><creatorcontrib>Zhu, Xiaofei</creatorcontrib><creatorcontrib>Xiang, Wang</creatorcontrib><creatorcontrib>Wu, Yonghe</creatorcontrib><creatorcontrib>Lin, Shibin</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Evidence-based complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yuan, Mengxia</au><au>He, Qi</au><au>Long, Zhiyong</au><au>Zhu, Xiaofei</au><au>Xiang, Wang</au><au>Wu, Yonghe</au><au>Lin, Shibin</au><au>Kuan, Yu Hsiang</au><au>Yu Hsiang Kuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exploring the Pharmacological Mechanism of Liuwei Dihuang Decoction for Diabetic Retinopathy: A Systematic Biological Strategy-Based Research</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2021</date><risdate>2021</risdate><volume>2021</volume><spage>5544518</spage><epage>20</epage><pages>5544518-20</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Objective. To explore the pharmacological mechanism of Liuwei Dihuang decoction (LDD) for diabetic retinopathy (DR). Methods. The potential targets of LDD were predicted by PharmMapper. GeneCards and other databases were used to collect DR genes. Cytoscape was used to construct and analyze network DR and LDD’s network, and DAVID was used for Gene Ontology (GO) and pathway enrichment analysis. Finally, animal experiments were carried out to verify the results of systematic pharmacology. Results. Five networks were constructed and analyzed: (1) diabetic retinopathy genes’ PPI network; (2) compound-compound target network of LDD; (3) LDD-DR PPI network; (4) compound-known target network of LDD; (5) LDD known target-DR PPI network. Several DR and treatment-related targets, clusters, signaling pathways, and biological processes were found. Animal experiments found that LDD can improve the histopathological changes of the retina. LDD can also increase erythrocyte filtration rate and decrease the platelet adhesion rate (P<0.05) and decrease MDA and TXB2 (P<0.05). Compared with the model group, the retinal VEGF and HIF-1α expression in the LDD group decreased significantly (P<0.05). Conclusion. The therapeutic effect of LDD on DR may be achieved by interfering with the biological processes (such as response to insulin, glucose homeostasis, and regulation of angiogenesis) and signaling pathways (such as insulin, VEGF, HIF-1, and ErbB signaling pathway) related to the development of DR that was found in this research.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>34394383</pmid><doi>10.1155/2021/5544518</doi><tpages>20</tpages><orcidid>https://orcid.org/0000-0002-3243-8002</orcidid><orcidid>https://orcid.org/0000-0002-7307-0566</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Angiogenesis Animal research Chinese medicine Diabetes Diabetes mellitus Diabetic retinopathy Drug dosages Edema ErbB protein Glucose Homeostasis Hypoxia-inducible factor 1a Insulin Retina Retinopathy Signal transduction Vascular endothelial growth factor Visual impairment |
| title | Exploring the Pharmacological Mechanism of Liuwei Dihuang Decoction for Diabetic Retinopathy: A Systematic Biological Strategy-Based Research |
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