Protective effects of antidepressant citalopram against abnormal APP processing and amyloid beta-induced mitochondrial dynamics, biogenesis, mitophagy and synaptic toxicities in Alzheimer’s disease

Abstract The purpose of this study is to study the neuroprotective role of selective serotonin reuptake inhibitor (SSRI), citalopram, against Alzheimer’s disease (AD). Multiple SSRIs, including citalopram, are reported to treat patients with depression, anxiety and AD. However, their protective cell...

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Veröffentlicht in:	Human molecular genetics 2021-05, Vol.30 (10), p.847-864
Hauptverfasser:	Reddy, Arubala P, Yin, Xiangling, Sawant, Neha, Reddy, P Hemachandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - genetics Alzheimer Disease - pathology Amyloid beta-Peptides - genetics Amyloid beta-Protein Precursor - genetics Animals Autophagy - drug effects Autophagy - genetics Citalopram - pharmacology Disease Models, Animal Hippocampus - drug effects Hippocampus - pathology Humans Mice Mitochondria - drug effects Mitochondria - genetics Mitochondrial Dynamics - drug effects Mitochondrial Dynamics - genetics Mitophagy - drug effects Neurons - drug effects Neurons - pathology Organelle Biogenesis Synapses - drug effects Synapses - genetics
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