Circulating Procollagen Type III N-Terminal Peptide and Physical Function in Adults from the Long Life Family Study

Circulating Procollagen Type III N-Terminal Peptide and Physical Function in Adults from the Long Life Family Study

Abstract Background Circulating levels of procollagen type III N-terminal peptide (P3NP) may reflect increased fibrosis of skeletal muscle and other tissues with aging. Herein, we tested if P3NP was associated with baseline and 7-year change in physical function. Method Participants (n = 400) were f...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2021-06, Vol.76 (7), p.1273-1279
Hauptverfasser: Santanasto, Adam J, Cvejkus, Ryan K, Wojczynski, Mary K, Marron, Megan M, Schupf, Nicole, Christensen, Kaare, Thyagarajan, Bharat, Zmuda, Joseph M
Format: Artikel
Sprache:eng
Schlagworte:
Aging
Balance
Body mass index
Enzyme-linked immunosorbent assay
Fibrosis
Gait
Lung diseases
Muscular system
Peptides
Procollagen
Respiratory function
Skeletal muscle
Studies
THE JOURNAL OF GERONTOLOGY: Medical Sciences
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Abstract Background Circulating levels of procollagen type III N-terminal peptide (P3NP) may reflect increased fibrosis of skeletal muscle and other tissues with aging. Herein, we tested if P3NP was associated with baseline and 7-year change in physical function. Method Participants (n = 400) were from the Long Life Family Study, a study of exceptional familial longevity. Plasma P3NP concentration was measured using a sandwich enzyme-linked immunosorbent assay (inter-assay coefficient of variation
ISSN:1079-5006
1758-535X
DOI:10.1093/gerona/glaa197