Diet quality indices and dietary patterns are associated with plasma metabolites in colorectal cancer patients
Purpose Emerging evidence suggests that diet is linked to survival in colorectal cancer patients, although underlying mechanisms are not fully understood. The aim of this study was to evaluate whether dietary exposures are associated with metabolite concentrations in colorectal cancer patients. Meth...
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| Veröffentlicht in: | European journal of nutrition 2021-09, Vol.60 (6), p.3171-3184 |
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| creator | Geijsen, Anne J. M. R. Kok, Dieuwertje E. van Zutphen, Moniek Keski-Rahkonen, Pekka Achaintre, David Gicquiau, Audrey Gsur, Andrea Kruyt, Flip M. Ulrich, Cornelia M. Weijenberg, Matty P. de Wilt, Johannes H. W . Wesselink, Evertine Scalbert, Augustin Kampman, Ellen van Duijnhoven, Fränzel J. B. |
| description | Purpose
Emerging evidence suggests that diet is linked to survival in colorectal cancer patients, although underlying mechanisms are not fully understood. The aim of this study was to evaluate whether dietary exposures are associated with metabolite concentrations in colorectal cancer patients.
Methods
Concentrations of 134 metabolites of the Biocrates Absolute
IDQ
p180 kit were quantified in plasma samples collected at diagnosis from 195 stage I-IV colorectal cancer patients. Food frequency questionnaires were used to calculate adherence to the World Cancer Research Fund (WCRF) dietary recommendations and the Dutch Healthy Diet (DHD15) index as well as to construct dietary patterns using Principal Component Analysis. Multivariable linear regression models were used to determine associations between dietary exposures and metabolite concentrations. All models were adjusted for age, sex, body mass index, smoking status, analytical batch, cancer stage, and multiple testing using false discovery rate.
Results
Participants had a mean (SD) age of 66 (9) years, were mostly men (60%), and mostly diagnosed with stage II and III cancer. For the dietary pattern analyses, Western, Carnivore, and Prudent patterns were identified. Better adherence to the WCRF dietary recommendations was associated with lower concentrations of ten phosphatidylcholines. Higher intake of the Carnivore pattern was associated with higher concentrations of two phosphatidylcholines. The DHD15-index, Western pattern, or Prudent pattern were not associated with metabolite concentrations.
Conclusion
In the current study, the WCRF dietary score and the Carnivore pattern are associated with phosphatidylcholines. Future research should elucidate the potential relevance of phosphatidylcholine metabolism in the colorectal cancer continuum.
Clinical trial registry
ClinicalTrials.gov Identifier: NCT03191110. |
| doi_str_mv | 10.1007/s00394-021-02488-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8354955</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2559956422</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-222dbe8ec7a3b781d137bfc11ab39a219ca556e3fa268d43da521ab58550f0aa3</originalsourceid><addsrcrecordid>eNp9UctuFTEMHSEQLYUfYIEisWEzkOc8NkioPKVKbGAdeRJPm2omuU0yoP49vtxyeSxYJLF8jo9jn6Z5KvhLwXn_qnCuRt1yKejoYWjFveZUaNW1nRTm_jHm_UnzqJRrzrlUnXjYnChltKb8aRPfBqzsZoMl1FsWog8OC4PomScA8i3bQa2YIyUzMigluQAVPfse6hXbLVBWYCtRp0QSVBsic2lJGV2FhTmIDvNeJGCs5XHzYIal4JO796z5-v7dl_OP7cXnD5_O31y0Tve6tlJKP-GArgc19YPwQvXT7ISASY0gxejAmA7VDLIbvFYejCTMDMbwmQOos-b1QXe3TSt6R70zLHaXw0oz2QTB_o3EcGUv0zc70GZGY0jgxZ1ATjcblmrXUBwuC0RMW7G0714YThdRn_9DvU5bjjSelcaMo-m0lMSSB5bLqZSM8_Ezgtu9nfZgpyU77U877V762Z9jHEt--UcEdSAUguIl5t-9_yP7A8nkrb4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2559956422</pqid></control><display><type>article</type><title>Diet quality indices and dietary patterns are associated with plasma metabolites in colorectal cancer patients</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Geijsen, Anne J. M. R. ; Kok, Dieuwertje E. ; van Zutphen, Moniek ; Keski-Rahkonen, Pekka ; Achaintre, David ; Gicquiau, Audrey ; Gsur, Andrea ; Kruyt, Flip M. ; Ulrich, Cornelia M. ; Weijenberg, Matty P. ; de Wilt, Johannes H. W . ; Wesselink, Evertine ; Scalbert, Augustin ; Kampman, Ellen ; van Duijnhoven, Fränzel J. B.</creator><creatorcontrib>Geijsen, Anne J. M. R. ; Kok, Dieuwertje E. ; van Zutphen, Moniek ; Keski-Rahkonen, Pekka ; Achaintre, David ; Gicquiau, Audrey ; Gsur, Andrea ; Kruyt, Flip M. ; Ulrich, Cornelia M. ; Weijenberg, Matty P. ; de Wilt, Johannes H. W . ; Wesselink, Evertine ; Scalbert, Augustin ; Kampman, Ellen ; van Duijnhoven, Fränzel J. B.</creatorcontrib><description>Purpose
Emerging evidence suggests that diet is linked to survival in colorectal cancer patients, although underlying mechanisms are not fully understood. The aim of this study was to evaluate whether dietary exposures are associated with metabolite concentrations in colorectal cancer patients.
Methods
Concentrations of 134 metabolites of the Biocrates Absolute
IDQ
p180 kit were quantified in plasma samples collected at diagnosis from 195 stage I-IV colorectal cancer patients. Food frequency questionnaires were used to calculate adherence to the World Cancer Research Fund (WCRF) dietary recommendations and the Dutch Healthy Diet (DHD15) index as well as to construct dietary patterns using Principal Component Analysis. Multivariable linear regression models were used to determine associations between dietary exposures and metabolite concentrations. All models were adjusted for age, sex, body mass index, smoking status, analytical batch, cancer stage, and multiple testing using false discovery rate.
Results
Participants had a mean (SD) age of 66 (9) years, were mostly men (60%), and mostly diagnosed with stage II and III cancer. For the dietary pattern analyses, Western, Carnivore, and Prudent patterns were identified. Better adherence to the WCRF dietary recommendations was associated with lower concentrations of ten phosphatidylcholines. Higher intake of the Carnivore pattern was associated with higher concentrations of two phosphatidylcholines. The DHD15-index, Western pattern, or Prudent pattern were not associated with metabolite concentrations.
Conclusion
In the current study, the WCRF dietary score and the Carnivore pattern are associated with phosphatidylcholines. Future research should elucidate the potential relevance of phosphatidylcholine metabolism in the colorectal cancer continuum.
Clinical trial registry
ClinicalTrials.gov Identifier: NCT03191110.</description><identifier>ISSN: 1436-6207</identifier><identifier>EISSN: 1436-6215</identifier><identifier>DOI: 10.1007/s00394-021-02488-1</identifier><identifier>PMID: 33544207</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Body Mass Index ; Cancer ; Cancer research ; Chemistry ; Chemistry and Materials Science ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms ; Diet ; Diet, Healthy ; Humans ; Lecithin ; Male ; Medical research ; Metabolites ; NCT ; NCT03191110 ; Nutrition ; Original Contribution ; Patients ; Phosphatidylcholine ; Principal components analysis ; Regression analysis</subject><ispartof>European journal of nutrition, 2021-09, Vol.60 (6), p.3171-3184</ispartof><rights>The Author(s) 2021</rights><rights>2021. The Author(s).</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-222dbe8ec7a3b781d137bfc11ab39a219ca556e3fa268d43da521ab58550f0aa3</citedby><cites>FETCH-LOGICAL-c474t-222dbe8ec7a3b781d137bfc11ab39a219ca556e3fa268d43da521ab58550f0aa3</cites><orcidid>0000-0001-8367-2352</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00394-021-02488-1$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00394-021-02488-1$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,778,782,883,27907,27908,41471,42540,51302</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33544207$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Geijsen, Anne J. M. R.</creatorcontrib><creatorcontrib>Kok, Dieuwertje E.</creatorcontrib><creatorcontrib>van Zutphen, Moniek</creatorcontrib><creatorcontrib>Keski-Rahkonen, Pekka</creatorcontrib><creatorcontrib>Achaintre, David</creatorcontrib><creatorcontrib>Gicquiau, Audrey</creatorcontrib><creatorcontrib>Gsur, Andrea</creatorcontrib><creatorcontrib>Kruyt, Flip M.</creatorcontrib><creatorcontrib>Ulrich, Cornelia M.</creatorcontrib><creatorcontrib>Weijenberg, Matty P.</creatorcontrib><creatorcontrib>de Wilt, Johannes H. W .</creatorcontrib><creatorcontrib>Wesselink, Evertine</creatorcontrib><creatorcontrib>Scalbert, Augustin</creatorcontrib><creatorcontrib>Kampman, Ellen</creatorcontrib><creatorcontrib>van Duijnhoven, Fränzel J. B.</creatorcontrib><title>Diet quality indices and dietary patterns are associated with plasma metabolites in colorectal cancer patients</title><title>European journal of nutrition</title><addtitle>Eur J Nutr</addtitle><addtitle>Eur J Nutr</addtitle><description>Purpose
Emerging evidence suggests that diet is linked to survival in colorectal cancer patients, although underlying mechanisms are not fully understood. The aim of this study was to evaluate whether dietary exposures are associated with metabolite concentrations in colorectal cancer patients.
Methods
Concentrations of 134 metabolites of the Biocrates Absolute
IDQ
p180 kit were quantified in plasma samples collected at diagnosis from 195 stage I-IV colorectal cancer patients. Food frequency questionnaires were used to calculate adherence to the World Cancer Research Fund (WCRF) dietary recommendations and the Dutch Healthy Diet (DHD15) index as well as to construct dietary patterns using Principal Component Analysis. Multivariable linear regression models were used to determine associations between dietary exposures and metabolite concentrations. All models were adjusted for age, sex, body mass index, smoking status, analytical batch, cancer stage, and multiple testing using false discovery rate.
Results
Participants had a mean (SD) age of 66 (9) years, were mostly men (60%), and mostly diagnosed with stage II and III cancer. For the dietary pattern analyses, Western, Carnivore, and Prudent patterns were identified. Better adherence to the WCRF dietary recommendations was associated with lower concentrations of ten phosphatidylcholines. Higher intake of the Carnivore pattern was associated with higher concentrations of two phosphatidylcholines. The DHD15-index, Western pattern, or Prudent pattern were not associated with metabolite concentrations.
Conclusion
In the current study, the WCRF dietary score and the Carnivore pattern are associated with phosphatidylcholines. Future research should elucidate the potential relevance of phosphatidylcholine metabolism in the colorectal cancer continuum.
Clinical trial registry
ClinicalTrials.gov Identifier: NCT03191110.</description><subject>Aged</subject><subject>Body Mass Index</subject><subject>Cancer</subject><subject>Cancer research</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms</subject><subject>Diet</subject><subject>Diet, Healthy</subject><subject>Humans</subject><subject>Lecithin</subject><subject>Male</subject><subject>Medical research</subject><subject>Metabolites</subject><subject>NCT</subject><subject>NCT03191110</subject><subject>Nutrition</subject><subject>Original Contribution</subject><subject>Patients</subject><subject>Phosphatidylcholine</subject><subject>Principal components analysis</subject><subject>Regression analysis</subject><issn>1436-6207</issn><issn>1436-6215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp9UctuFTEMHSEQLYUfYIEisWEzkOc8NkioPKVKbGAdeRJPm2omuU0yoP49vtxyeSxYJLF8jo9jn6Z5KvhLwXn_qnCuRt1yKejoYWjFveZUaNW1nRTm_jHm_UnzqJRrzrlUnXjYnChltKb8aRPfBqzsZoMl1FsWog8OC4PomScA8i3bQa2YIyUzMigluQAVPfse6hXbLVBWYCtRp0QSVBsic2lJGV2FhTmIDvNeJGCs5XHzYIal4JO796z5-v7dl_OP7cXnD5_O31y0Tve6tlJKP-GArgc19YPwQvXT7ISASY0gxejAmA7VDLIbvFYejCTMDMbwmQOos-b1QXe3TSt6R70zLHaXw0oz2QTB_o3EcGUv0zc70GZGY0jgxZ1ATjcblmrXUBwuC0RMW7G0714YThdRn_9DvU5bjjSelcaMo-m0lMSSB5bLqZSM8_Ezgtu9nfZgpyU77U877V762Z9jHEt--UcEdSAUguIl5t-9_yP7A8nkrb4</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Geijsen, Anne J. 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B.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8367-2352</orcidid></search><sort><creationdate>20210901</creationdate><title>Diet quality indices and dietary patterns are associated with plasma metabolites in colorectal cancer patients</title><author>Geijsen, Anne J. M. R. ; Kok, Dieuwertje E. ; van Zutphen, Moniek ; Keski-Rahkonen, Pekka ; Achaintre, David ; Gicquiau, Audrey ; Gsur, Andrea ; Kruyt, Flip M. ; Ulrich, Cornelia M. ; Weijenberg, Matty P. ; de Wilt, Johannes H. W . ; Wesselink, Evertine ; Scalbert, Augustin ; Kampman, Ellen ; van Duijnhoven, Fränzel J. 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M. R.</au><au>Kok, Dieuwertje E.</au><au>van Zutphen, Moniek</au><au>Keski-Rahkonen, Pekka</au><au>Achaintre, David</au><au>Gicquiau, Audrey</au><au>Gsur, Andrea</au><au>Kruyt, Flip M.</au><au>Ulrich, Cornelia M.</au><au>Weijenberg, Matty P.</au><au>de Wilt, Johannes H. W .</au><au>Wesselink, Evertine</au><au>Scalbert, Augustin</au><au>Kampman, Ellen</au><au>van Duijnhoven, Fränzel J. B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diet quality indices and dietary patterns are associated with plasma metabolites in colorectal cancer patients</atitle><jtitle>European journal of nutrition</jtitle><stitle>Eur J Nutr</stitle><addtitle>Eur J Nutr</addtitle><date>2021-09-01</date><risdate>2021</risdate><volume>60</volume><issue>6</issue><spage>3171</spage><epage>3184</epage><pages>3171-3184</pages><issn>1436-6207</issn><eissn>1436-6215</eissn><abstract>Purpose
Emerging evidence suggests that diet is linked to survival in colorectal cancer patients, although underlying mechanisms are not fully understood. The aim of this study was to evaluate whether dietary exposures are associated with metabolite concentrations in colorectal cancer patients.
Methods
Concentrations of 134 metabolites of the Biocrates Absolute
IDQ
p180 kit were quantified in plasma samples collected at diagnosis from 195 stage I-IV colorectal cancer patients. Food frequency questionnaires were used to calculate adherence to the World Cancer Research Fund (WCRF) dietary recommendations and the Dutch Healthy Diet (DHD15) index as well as to construct dietary patterns using Principal Component Analysis. Multivariable linear regression models were used to determine associations between dietary exposures and metabolite concentrations. All models were adjusted for age, sex, body mass index, smoking status, analytical batch, cancer stage, and multiple testing using false discovery rate.
Results
Participants had a mean (SD) age of 66 (9) years, were mostly men (60%), and mostly diagnosed with stage II and III cancer. For the dietary pattern analyses, Western, Carnivore, and Prudent patterns were identified. Better adherence to the WCRF dietary recommendations was associated with lower concentrations of ten phosphatidylcholines. Higher intake of the Carnivore pattern was associated with higher concentrations of two phosphatidylcholines. The DHD15-index, Western pattern, or Prudent pattern were not associated with metabolite concentrations.
Conclusion
In the current study, the WCRF dietary score and the Carnivore pattern are associated with phosphatidylcholines. Future research should elucidate the potential relevance of phosphatidylcholine metabolism in the colorectal cancer continuum.
Clinical trial registry
ClinicalTrials.gov Identifier: NCT03191110.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33544207</pmid><doi>10.1007/s00394-021-02488-1</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0001-8367-2352</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1436-6207 |
| ispartof | European journal of nutrition, 2021-09, Vol.60 (6), p.3171-3184 |
| issn | 1436-6207 1436-6215 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Aged Body Mass Index Cancer Cancer research Chemistry Chemistry and Materials Science Colorectal cancer Colorectal carcinoma Colorectal Neoplasms Diet Diet, Healthy Humans Lecithin Male Medical research Metabolites NCT NCT03191110 Nutrition Original Contribution Patients Phosphatidylcholine Principal components analysis Regression analysis |
| title | Diet quality indices and dietary patterns are associated with plasma metabolites in colorectal cancer patients |
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