Potency and pharmacokinetics of GS-441524 derivatives against SARS-CoV-2

[Display omitted] The nucleoside metabolite of remdesivir, GS-441524 displays potent anti-SARS-CoV-2 efficacy, and is being evaluated in clinical as an oral antiviral therapeutic for COVID-19. However, this nucleoside has a poor oral bioavailability in non-human primates, which may affect its therap...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2021-09, Vol.46, p.116364-116364, Article 116364
Hauptverfasser:	Wei, Daibao, Hu, Tianwen, Zhang, Yumin, Zheng, Wei, Xue, Haitao, Shen, Jingshan, Xie, Yuanchao, Aisa, Haji A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - pharmacokinetics Adenosine - pharmacology Adenosine - toxicity Animals Antiviral Antiviral Agents - chemical synthesis Antiviral Agents - pharmacokinetics Antiviral Agents - pharmacology Antiviral Agents - toxicity Chlorocebus aethiops Covid-19 GS-441524 Isobutyrate Male Mice Mice, Inbred ICR Microbial Sensitivity Tests Nucleoside Prodrug Prodrugs - chemical synthesis Prodrugs - pharmacokinetics Prodrugs - pharmacology Prodrugs - toxicity SARS-CoV-2 SARS-CoV-2 - drug effects Vero Cells
Online-Zugang:	Volltext
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