Acute Myocarditis and Eculizumab Caused Severe Cholestasis in a 17-Month-Old Child Who Has Hemolytic Uremic Syndrome Associated with Shiga Toxin-Producing Escherichia coli

Acute Myocarditis and Eculizumab Caused Severe Cholestasis in a 17-Month-Old Child Who Has Hemolytic Uremic Syndrome Associated with Shiga Toxin-Producing Escherichia coli

Abstract Cardiovascular involvement is uncommon in pediatric patients with hemolytic uremic syndrome associated with Shiga toxin-producing Escherichia coli (STEC-HUS). In this case report we presented a case of 17-month-old toddler who had a sporadic type of STEC-HUS complicated by acute myocarditis...

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Veröffentlicht in:Journal of pediatric intensive care 2021-09, Vol.10 (3), p.216-220
Hauptverfasser: Yesilbas, Osman, Yozgat, Can Yilmaz, Akinci, Nurver, Sonmez, Sirin, Tekin, Eser, Talebazadeh, Faraz, Jafarov, Uzeyir, Temur, Hafize Otcu, Yozgat, Yilmaz
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container_title Journal of pediatric intensive care
container_volume 10
creator Yesilbas, Osman
Yozgat, Can Yilmaz
Akinci, Nurver
Sonmez, Sirin
Tekin, Eser
Talebazadeh, Faraz
Jafarov, Uzeyir
Temur, Hafize Otcu
Yozgat, Yilmaz
description Abstract Cardiovascular involvement is uncommon in pediatric patients with hemolytic uremic syndrome associated with Shiga toxin-producing Escherichia coli (STEC-HUS). In this case report we presented a case of 17-month-old toddler who had a sporadic type of STEC-HUS complicated by acute myocarditis. The patient was successfully treated by a single dose of eculizumab after six doses of therapeutic plasma exchange (TPE) were inefficient to prevent the cardiac complication. Hepatotoxicity was observed after a single dose of eculizumab. Hepatic and cholestatic enzyme levels slowly returned to normal within 6 months. To the best of our knowledge, this is the first case of myocarditis/cardiomyopathy treated with eculizumab in STEC-HUS. This case illustrates the need for vigilance regarding myocardial involvement and eculizumab-induced hepatotoxicity in STEC-HUS.
doi_str_mv 10.1055/s-0040-1713111
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title Acute Myocarditis and Eculizumab Caused Severe Cholestasis in a 17-Month-Old Child Who Has Hemolytic Uremic Syndrome Associated with Shiga Toxin-Producing Escherichia coli
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