Longitudinal Analysis of Quality-of-Life Recovery After Gastrectomy for Cancer
Objective The purpose of this study was to identify factors associated with quality-of-life recovery after gastrectomy. Methods Patients anticipated to undergo gastric cancer resection were invited to complete the European Organisation for Research and Treatment of Cancer (EORTC) QLQ C30 and STO22 s...
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| Veröffentlicht in: | Annals of surgical oncology 2021-01, Vol.28 (1), p.48-56 |
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| creator | Hu, Yinin Vos, Elvira L. Baser, Raymond E. Schattner, Mark A. Nishimura, Makoto Coit, Daniel G. Strong, Vivian E. |
| description | Objective
The purpose of this study was to identify factors associated with quality-of-life recovery after gastrectomy.
Methods
Patients anticipated to undergo gastric cancer resection were invited to complete the European Organisation for Research and Treatment of Cancer (EORTC) QLQ C30 and STO22 surveys in the preoperative setting and at 0–1.5 months (early), > 1.5–6 months (intermediate), and > 6–18 months (late) following resection. Quality-of-life recovery was measured as paired differences between pre- and postoperative results. Multivariable linear regression identified factors associated with preoperative quality of life and degree of change following resection.
Results
Across 393 participants, response rates at the intermediate and late postoperative time points were 58% (
n
= 228) and 71% (
n
= 277), respectively. Relative to baseline, median global health scale decreased in the early (− 15.1 pts,
p
|
| doi_str_mv | 10.1245/s10434-020-09274-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8354003</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2456412932</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-75f7f182d6b7a1d020b483f5ce95ab510fa60fc95c78bd67604ae16badd77a633</originalsourceid><addsrcrecordid>eNp9kUtrGzEUhUVJqZ20f6CLMNBNN0r01swmYEzzAJOSkK6FRiO5CuORI80Yxr8-cpy6aRfZSEL3u0c69wDwFaMzTBg_TxgxyiAiCKKKSAa3H8AU83zFRImP8hmJElZE8Ak4TukRISwp4p_AhFJMOBfVFNwuQrf0_dD4TrfFLC9j8qkIrrgbdOv7EQYHF97Z4t6asLFxLGaut7G40qmP1vRhNRYuxGKuO2PjZ_DR6TbZL6_7Cfh1-eNhfg0XP69u5rMFNEyyHkrupMMlaUQtNW6yg5qV1HFjK65rjpHTAjlTcSPLuhFSIKYtFrVuGim1oPQEXOx110O9so2xXR91q9bRr3QcVdBe_Vvp_G-1DBtVUs4Q2gl8fxWI4WmwqVcrn4xtW93ZMCSV5ysYJhUlGf32H_oYhpgntaMkzYPk5U6Q7CkTQ0rRusNnMFK7uNQ-LpXNqpe41DY3nb61cWj5k08G6B5IudQtbfz79juyz4i_oac</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2473255583</pqid></control><display><type>article</type><title>Longitudinal Analysis of Quality-of-Life Recovery After Gastrectomy for Cancer</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Hu, Yinin ; Vos, Elvira L. ; Baser, Raymond E. ; Schattner, Mark A. ; Nishimura, Makoto ; Coit, Daniel G. ; Strong, Vivian E.</creator><creatorcontrib>Hu, Yinin ; Vos, Elvira L. ; Baser, Raymond E. ; Schattner, Mark A. ; Nishimura, Makoto ; Coit, Daniel G. ; Strong, Vivian E.</creatorcontrib><description>Objective
The purpose of this study was to identify factors associated with quality-of-life recovery after gastrectomy.
Methods
Patients anticipated to undergo gastric cancer resection were invited to complete the European Organisation for Research and Treatment of Cancer (EORTC) QLQ C30 and STO22 surveys in the preoperative setting and at 0–1.5 months (early), > 1.5–6 months (intermediate), and > 6–18 months (late) following resection. Quality-of-life recovery was measured as paired differences between pre- and postoperative results. Multivariable linear regression identified factors associated with preoperative quality of life and degree of change following resection.
Results
Across 393 participants, response rates at the intermediate and late postoperative time points were 58% (
n
= 228) and 71% (
n
= 277), respectively. Relative to baseline, median global health scale decreased in the early (− 15.1 pts,
p
< 0.001) and intermediate (− 3.6 pts,
p
= 0.02) time points, but recovered by the late time point (+ 1.2 pts,
p
= 0.411). Relative to distal/subtotal gastrectomy, proximal/total gastrectomy was associated with worse recovery in both the early and late time points. Surgical complications were associated with worse early recovery. Patients who presented with locally advanced tumors (T3–T4) had lower preoperative quality-of-life scores, and more readily recovered to baseline after surgery. A minimally invasive approach was not associated with postoperative recovery.
Conclusions
Most patients recover to baseline within 1 year following major gastrectomy, and recovery is easier with more limited resections. Patients with locally advanced tumors tend to have poorer baseline quality of life, which may improve following resection.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-020-09274-z</identifier><identifier>PMID: 33125569</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Cancer ; Gastrectomy ; Gastric cancer ; Health Services Research and Global Oncology ; Humans ; Medicine ; Medicine & Public Health ; Oncology ; Patients ; Postoperative Period ; Public health ; Quality of Life ; Recovery (Medical) ; Stomach Neoplasms - surgery ; Surgery ; Surgical Oncology ; Surveys and Questionnaires ; Tumors</subject><ispartof>Annals of surgical oncology, 2021-01, Vol.28 (1), p.48-56</ispartof><rights>Society of Surgical Oncology 2020</rights><rights>Society of Surgical Oncology 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-75f7f182d6b7a1d020b483f5ce95ab510fa60fc95c78bd67604ae16badd77a633</citedby><cites>FETCH-LOGICAL-c474t-75f7f182d6b7a1d020b483f5ce95ab510fa60fc95c78bd67604ae16badd77a633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-020-09274-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-020-09274-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33125569$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hu, Yinin</creatorcontrib><creatorcontrib>Vos, Elvira L.</creatorcontrib><creatorcontrib>Baser, Raymond E.</creatorcontrib><creatorcontrib>Schattner, Mark A.</creatorcontrib><creatorcontrib>Nishimura, Makoto</creatorcontrib><creatorcontrib>Coit, Daniel G.</creatorcontrib><creatorcontrib>Strong, Vivian E.</creatorcontrib><title>Longitudinal Analysis of Quality-of-Life Recovery After Gastrectomy for Cancer</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Objective
The purpose of this study was to identify factors associated with quality-of-life recovery after gastrectomy.
Methods
Patients anticipated to undergo gastric cancer resection were invited to complete the European Organisation for Research and Treatment of Cancer (EORTC) QLQ C30 and STO22 surveys in the preoperative setting and at 0–1.5 months (early), > 1.5–6 months (intermediate), and > 6–18 months (late) following resection. Quality-of-life recovery was measured as paired differences between pre- and postoperative results. Multivariable linear regression identified factors associated with preoperative quality of life and degree of change following resection.
Results
Across 393 participants, response rates at the intermediate and late postoperative time points were 58% (
n
= 228) and 71% (
n
= 277), respectively. Relative to baseline, median global health scale decreased in the early (− 15.1 pts,
p
< 0.001) and intermediate (− 3.6 pts,
p
= 0.02) time points, but recovered by the late time point (+ 1.2 pts,
p
= 0.411). Relative to distal/subtotal gastrectomy, proximal/total gastrectomy was associated with worse recovery in both the early and late time points. Surgical complications were associated with worse early recovery. Patients who presented with locally advanced tumors (T3–T4) had lower preoperative quality-of-life scores, and more readily recovered to baseline after surgery. A minimally invasive approach was not associated with postoperative recovery.
Conclusions
Most patients recover to baseline within 1 year following major gastrectomy, and recovery is easier with more limited resections. Patients with locally advanced tumors tend to have poorer baseline quality of life, which may improve following resection.</description><subject>Cancer</subject><subject>Gastrectomy</subject><subject>Gastric cancer</subject><subject>Health Services Research and Global Oncology</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Patients</subject><subject>Postoperative Period</subject><subject>Public health</subject><subject>Quality of Life</subject><subject>Recovery (Medical)</subject><subject>Stomach Neoplasms - surgery</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Surveys and Questionnaires</subject><subject>Tumors</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kUtrGzEUhUVJqZ20f6CLMNBNN0r01swmYEzzAJOSkK6FRiO5CuORI80Yxr8-cpy6aRfZSEL3u0c69wDwFaMzTBg_TxgxyiAiCKKKSAa3H8AU83zFRImP8hmJElZE8Ak4TukRISwp4p_AhFJMOBfVFNwuQrf0_dD4TrfFLC9j8qkIrrgbdOv7EQYHF97Z4t6asLFxLGaut7G40qmP1vRhNRYuxGKuO2PjZ_DR6TbZL6_7Cfh1-eNhfg0XP69u5rMFNEyyHkrupMMlaUQtNW6yg5qV1HFjK65rjpHTAjlTcSPLuhFSIKYtFrVuGim1oPQEXOx110O9so2xXR91q9bRr3QcVdBe_Vvp_G-1DBtVUs4Q2gl8fxWI4WmwqVcrn4xtW93ZMCSV5ysYJhUlGf32H_oYhpgntaMkzYPk5U6Q7CkTQ0rRusNnMFK7uNQ-LpXNqpe41DY3nb61cWj5k08G6B5IudQtbfz79juyz4i_oac</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Hu, Yinin</creator><creator>Vos, Elvira L.</creator><creator>Baser, Raymond E.</creator><creator>Schattner, Mark A.</creator><creator>Nishimura, Makoto</creator><creator>Coit, Daniel G.</creator><creator>Strong, Vivian E.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210101</creationdate><title>Longitudinal Analysis of Quality-of-Life Recovery After Gastrectomy for Cancer</title><author>Hu, Yinin ; Vos, Elvira L. ; Baser, Raymond E. ; Schattner, Mark A. ; Nishimura, Makoto ; Coit, Daniel G. ; Strong, Vivian E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-75f7f182d6b7a1d020b483f5ce95ab510fa60fc95c78bd67604ae16badd77a633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cancer</topic><topic>Gastrectomy</topic><topic>Gastric cancer</topic><topic>Health Services Research and Global Oncology</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Patients</topic><topic>Postoperative Period</topic><topic>Public health</topic><topic>Quality of Life</topic><topic>Recovery (Medical)</topic><topic>Stomach Neoplasms - surgery</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Surveys and Questionnaires</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hu, Yinin</creatorcontrib><creatorcontrib>Vos, Elvira L.</creatorcontrib><creatorcontrib>Baser, Raymond E.</creatorcontrib><creatorcontrib>Schattner, Mark A.</creatorcontrib><creatorcontrib>Nishimura, Makoto</creatorcontrib><creatorcontrib>Coit, Daniel G.</creatorcontrib><creatorcontrib>Strong, Vivian E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, Yinin</au><au>Vos, Elvira L.</au><au>Baser, Raymond E.</au><au>Schattner, Mark A.</au><au>Nishimura, Makoto</au><au>Coit, Daniel G.</au><au>Strong, Vivian E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal Analysis of Quality-of-Life Recovery After Gastrectomy for Cancer</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>28</volume><issue>1</issue><spage>48</spage><epage>56</epage><pages>48-56</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Objective
The purpose of this study was to identify factors associated with quality-of-life recovery after gastrectomy.
Methods
Patients anticipated to undergo gastric cancer resection were invited to complete the European Organisation for Research and Treatment of Cancer (EORTC) QLQ C30 and STO22 surveys in the preoperative setting and at 0–1.5 months (early), > 1.5–6 months (intermediate), and > 6–18 months (late) following resection. Quality-of-life recovery was measured as paired differences between pre- and postoperative results. Multivariable linear regression identified factors associated with preoperative quality of life and degree of change following resection.
Results
Across 393 participants, response rates at the intermediate and late postoperative time points were 58% (
n
= 228) and 71% (
n
= 277), respectively. Relative to baseline, median global health scale decreased in the early (− 15.1 pts,
p
< 0.001) and intermediate (− 3.6 pts,
p
= 0.02) time points, but recovered by the late time point (+ 1.2 pts,
p
= 0.411). Relative to distal/subtotal gastrectomy, proximal/total gastrectomy was associated with worse recovery in both the early and late time points. Surgical complications were associated with worse early recovery. Patients who presented with locally advanced tumors (T3–T4) had lower preoperative quality-of-life scores, and more readily recovered to baseline after surgery. A minimally invasive approach was not associated with postoperative recovery.
Conclusions
Most patients recover to baseline within 1 year following major gastrectomy, and recovery is easier with more limited resections. Patients with locally advanced tumors tend to have poorer baseline quality of life, which may improve following resection.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>33125569</pmid><doi>10.1245/s10434-020-09274-z</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2021-01, Vol.28 (1), p.48-56 |
| issn | 1068-9265 1534-4681 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8354003 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Cancer Gastrectomy Gastric cancer Health Services Research and Global Oncology Humans Medicine Medicine & Public Health Oncology Patients Postoperative Period Public health Quality of Life Recovery (Medical) Stomach Neoplasms - surgery Surgery Surgical Oncology Surveys and Questionnaires Tumors |
| title | Longitudinal Analysis of Quality-of-Life Recovery After Gastrectomy for Cancer |
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