Insulin-like growth factor-1 level is a poor diagnostic indicator of growth hormone deficiency
We evaluated the diagnostic accuracy of insulin-like growth factor-1 (IGF-1) for screening growth hormone deficiency (GHD) to determine the usefulness of IGF-1 as a screening test. Among 298 consecutive children who had short stature or decreased height velocity, we measured IGF-1 levels and perform...
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| Veröffentlicht in: | Scientific reports 2021-08, Vol.11 (1), p.16159-16159, Article 16159 |
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| creator | Iwayama, Hideyuki Kitagawa, Sachiko Sada, Jyun Miyamoto, Ryosuke Hayakawa, Tomohito Kuroyanagi, Yoshiyuki Muto, Taichiro Kurahashi, Hirokazu Ohashi, Wataru Takagi, Junko Okumura, Akihisa |
| description | We evaluated the diagnostic accuracy of insulin-like growth factor-1 (IGF-1) for screening growth hormone deficiency (GHD) to determine the usefulness of IGF-1 as a screening test. Among 298 consecutive children who had short stature or decreased height velocity, we measured IGF-1 levels and performed growth hormone (GH) secretion test using clonidine, arginine, and, in cases with different results of the two tests, L-dopa. Patients with congenital abnormalities were excluded. GHD was defined as peak GH ≤ 6.0 ng/mL in the two tests. We identified 60 and 238 patients with and without GHD, respectively. The mean IGF-1 standard deviation (SD) was not significantly different between the GHD and non-GHD groups (p = 0.23). Receiver operating characteristic curve analysis demonstrated the best diagnostic accuracy at an IGF-1 cutoff of − 1.493 SD, with 0.685 sensitivity, 0.417 specificity, 0.25 positive and 0.823 negative predictive values, and 0.517 area under the curve. Correlation analysis revealed that none of the items of patients’ characteristics increased the diagnostic power of IGF-1. IGF-1 level had poor diagnostic accuracy as a screening test for GHD. Therefore, IGF-1 should not be used alone for GHD screening. A predictive biomarker for GHD should be developed in the future. |
| doi_str_mv | 10.1038/s41598-021-95632-0 |
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Among 298 consecutive children who had short stature or decreased height velocity, we measured IGF-1 levels and performed growth hormone (GH) secretion test using clonidine, arginine, and, in cases with different results of the two tests, L-dopa. Patients with congenital abnormalities were excluded. GHD was defined as peak GH ≤ 6.0 ng/mL in the two tests. We identified 60 and 238 patients with and without GHD, respectively. The mean IGF-1 standard deviation (SD) was not significantly different between the GHD and non-GHD groups (p = 0.23). Receiver operating characteristic curve analysis demonstrated the best diagnostic accuracy at an IGF-1 cutoff of − 1.493 SD, with 0.685 sensitivity, 0.417 specificity, 0.25 positive and 0.823 negative predictive values, and 0.517 area under the curve. Correlation analysis revealed that none of the items of patients’ characteristics increased the diagnostic power of IGF-1. IGF-1 level had poor diagnostic accuracy as a screening test for GHD. Therefore, IGF-1 should not be used alone for GHD screening. A predictive biomarker for GHD should be developed in the future.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-021-95632-0</identifier><identifier>PMID: 34373538</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/163 ; 692/53 ; Accuracy ; Body height ; Clonidine ; Correlation analysis ; Growth hormones ; Humanities and Social Sciences ; Insulin ; Insulin-like growth factor I ; Insulin-like growth factors ; Levodopa ; multidisciplinary ; Physical growth ; Science ; Science (multidisciplinary)</subject><ispartof>Scientific reports, 2021-08, Vol.11 (1), p.16159-16159, Article 16159</ispartof><rights>The Author(s) 2021</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). 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Among 298 consecutive children who had short stature or decreased height velocity, we measured IGF-1 levels and performed growth hormone (GH) secretion test using clonidine, arginine, and, in cases with different results of the two tests, L-dopa. Patients with congenital abnormalities were excluded. GHD was defined as peak GH ≤ 6.0 ng/mL in the two tests. We identified 60 and 238 patients with and without GHD, respectively. The mean IGF-1 standard deviation (SD) was not significantly different between the GHD and non-GHD groups (p = 0.23). Receiver operating characteristic curve analysis demonstrated the best diagnostic accuracy at an IGF-1 cutoff of − 1.493 SD, with 0.685 sensitivity, 0.417 specificity, 0.25 positive and 0.823 negative predictive values, and 0.517 area under the curve. Correlation analysis revealed that none of the items of patients’ characteristics increased the diagnostic power of IGF-1. IGF-1 level had poor diagnostic accuracy as a screening test for GHD. Therefore, IGF-1 should not be used alone for GHD screening. A predictive biomarker for GHD should be developed in the future.</description><subject>692/163</subject><subject>692/53</subject><subject>Accuracy</subject><subject>Body height</subject><subject>Clonidine</subject><subject>Correlation analysis</subject><subject>Growth hormones</subject><subject>Humanities and Social Sciences</subject><subject>Insulin</subject><subject>Insulin-like growth factor I</subject><subject>Insulin-like growth factors</subject><subject>Levodopa</subject><subject>multidisciplinary</subject><subject>Physical growth</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNp9kktv1DAURiMEolXpH2BliQ2bgJ-JvUFCFY-RKrHpGuvGuc54yNiDnSnqv8fTlEdZ4I0t-9yjq-uvaV4y-oZRod8WyZTRLeWsNaoTvKVPmnNOpWq54PzpX-ez5rKUHa1LcSOZed6cCSl6oYQ-b75uYjnOIbZz-IZkyunHsiUe3JJyy8iMtziTUAiQQ0qZjAGmmMoSHAlxDA4qRpL_VbdNeZ8ikhF9cAGju3vRPPMwF7x82C-am48fbq4-t9dfPm2u3l-3TmmxtGbwDI3rtTEoKRqpPaA0PaW6w_HU9qg8Zx1ohoxJLgzltPO97NkADMRFs1m1Y4KdPeSwh3xnEwR7f5HyZCHXrme0I0gluWLSjVRK8FBH5JQcvGSAg-yr693qOhyHPY4O45JhfiR9_BLD1k7p1mqhuNYnwesHQU7fj1gWuw_F4TxDxHQslquufkWnNK3oq3_QXTrmWCdVKWWUpMLISvGVcjmVktH_boZRewqDXcNgaxjsfRjsSS3WolLhOGH-o_5P1U-_c7VZ</recordid><startdate>20210809</startdate><enddate>20210809</enddate><creator>Iwayama, Hideyuki</creator><creator>Kitagawa, Sachiko</creator><creator>Sada, Jyun</creator><creator>Miyamoto, Ryosuke</creator><creator>Hayakawa, Tomohito</creator><creator>Kuroyanagi, Yoshiyuki</creator><creator>Muto, Taichiro</creator><creator>Kurahashi, Hirokazu</creator><creator>Ohashi, Wataru</creator><creator>Takagi, Junko</creator><creator>Okumura, Akihisa</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><general>Nature Portfolio</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20210809</creationdate><title>Insulin-like growth factor-1 level is a poor diagnostic indicator of growth hormone deficiency</title><author>Iwayama, Hideyuki ; 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Among 298 consecutive children who had short stature or decreased height velocity, we measured IGF-1 levels and performed growth hormone (GH) secretion test using clonidine, arginine, and, in cases with different results of the two tests, L-dopa. Patients with congenital abnormalities were excluded. GHD was defined as peak GH ≤ 6.0 ng/mL in the two tests. We identified 60 and 238 patients with and without GHD, respectively. The mean IGF-1 standard deviation (SD) was not significantly different between the GHD and non-GHD groups (p = 0.23). Receiver operating characteristic curve analysis demonstrated the best diagnostic accuracy at an IGF-1 cutoff of − 1.493 SD, with 0.685 sensitivity, 0.417 specificity, 0.25 positive and 0.823 negative predictive values, and 0.517 area under the curve. Correlation analysis revealed that none of the items of patients’ characteristics increased the diagnostic power of IGF-1. IGF-1 level had poor diagnostic accuracy as a screening test for GHD. Therefore, IGF-1 should not be used alone for GHD screening. A predictive biomarker for GHD should be developed in the future.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>34373538</pmid><doi>10.1038/s41598-021-95632-0</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 692/163 692/53 Accuracy Body height Clonidine Correlation analysis Growth hormones Humanities and Social Sciences Insulin Insulin-like growth factor I Insulin-like growth factors Levodopa multidisciplinary Physical growth Science Science (multidisciplinary) |
| title | Insulin-like growth factor-1 level is a poor diagnostic indicator of growth hormone deficiency |
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