High Mobility Group Box 1 Release by Cholangiocytes Governs Biliary Atresia Pathogenesis and Correlates With Increases in Afflicted Infants

Background and Aims Biliary atresia (BA) is a devastating cholangiopathy of infancy. Upon diagnosis, surgical reconstruction by Kasai hepatoportoenterostomy (HPE) restores biliary drainage in a subset of patients, but most patients develop fibrosis and progress to end‐stage liver disease requiring l...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2021-08, Vol.74 (2), p.864-878
Hauptverfasser:	Mohanty, Sujit K., Donnelly, Bryan, Temple, Haley, Ortiz‐Perez, Ana, Mowery, Sarah, Lobeck, Inna, Dupree, Phylicia, Poling, Holly M., McNeal, Monica, Mourya, Reena, Jenkins, Todd, Bansal, Ruchi, Bezerra, Jorge, Tiao, Greg
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Animals, Newborn Bile Ducts - metabolism Bile Ducts - pathology Bile Ducts - surgery Biliary atresia Biliary Atresia - blood Biliary Atresia - pathology Biliary Atresia - surgery Biliary Atresia - virology Bilirubin Bilirubin - blood Biomarkers - blood Cell Line Child, Preschool Children Chlorocebus aethiops Disease Models, Animal End Stage Liver Disease - epidemiology End Stage Liver Disease - pathology Epithelial Cells Fibrosis Glycyrrhizin Hepatology HMGB1 protein HMGB1 Protein - blood HMGB1 Protein - metabolism Humans Infant Infant, Newborn Infants Kinases Liver diseases Liver transplantation Mice Mobility Original Pathogenesis Patients Portoenterostomy, Hepatic Protein kinase Pyruvic acid Reconstructive surgery Risk Assessment Risk Factors Rotavirus Rotavirus - metabolism Rotavirus - pathogenicity Rotavirus Infections - pathology Rotavirus Infections - virology Signal transduction Survival Therapeutic applications Treatment Outcome
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