SARS-CoV-2 and Acute Cerebrovascular Events: An Overview
Since the coronavirus disease 2019 (COVID-19) pandemic, due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, accumulating evidence indicates that SARS-CoV-2 infection may be associated with various neurological manifestations, including acute cerebrovascular events (i.e., s...
Gespeichert in:
| Veröffentlicht in: | Journal of clinical medicine 2021-07, Vol.10 (15), p.3349 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 15 |
| container_start_page | 3349 |
| container_title | Journal of clinical medicine |
| container_volume | 10 |
| creator | Ghasemi, Mehdi Umeton, Raffaella Pizzolato Keyhanian, Kiandokht Mohit, Babak Rahimian, Nasrin Eshaghhosseiny, Niloofarsadaat Davoudi, Vahid |
| description | Since the coronavirus disease 2019 (COVID-19) pandemic, due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, accumulating evidence indicates that SARS-CoV-2 infection may be associated with various neurological manifestations, including acute cerebrovascular events (i.e., stroke and cerebral venous thrombosis). These events can occur prior to, during and even after the onset of COVID-19's general symptoms. Although the mechanisms underlying the cerebrovascular complications in patients with COVID-19 are yet to be fully elucidated, the hypercoagulability state, inflammation and altered angiotensin-converting enzyme 2 (ACE-2) signaling in association with SARS-CoV-2 may play key roles. ACE-2 plays a critical role in preserving heart and brain homeostasis. In this review, we discuss the current state of knowledge of the possible mechanisms underlying the acute cerebrovascular events in patients with COVID-19, and we review the current epidemiological studies and case reports of neurovascular complications in association with SARS-CoV-2, as well as the relevant therapeutic approaches that have been considered worldwide. As the number of published COVID-19 cases with cerebrovascular events is growing, prospective studies would help gather more valuable insights into the pathophysiology of cerebrovascular events, effective therapies, and the factors predicting poor functional outcomes related to such events in COVID-19 patients. |
| doi_str_mv | 10.3390/jcm10153349 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8348889</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2558836354</sourcerecordid><originalsourceid>FETCH-LOGICAL-c409t-f30540ee8e5820211ebbbe9c44d2f6e660c7f87c11238a789971104de60bee2e3</originalsourceid><addsrcrecordid>eNpdkc1Lw0AQxRdRrNSevEvAiyDR3Z1NsutBCKV-QKFg1euy2U40JU3qbhPxvzeltVTnMgPz4_Eej5AzRq8BFL2Z2wWjLAIQ6oCccJokIQUJh3t3jwy8n9NupBScJcekBwJizgBOiJymz9NwWL-FPDDVLEhts8JgiA4zV7fG26Y0Lhi1WK38bZBWwaRF1xb4dUqOclN6HGx3n7zej16Gj-F48vA0TMehFVStwhxoJCiixEhyyhnDLMtQWSFmPI8xjqlNcplYxjhIk0ilEsaomGFMM0SO0Cd3G91lky1wZjsjzpR66YqFcd-6NoX--6mKD_1et1qCkFKqTuByK-Dqzwb9Si8Kb7EsTYV14zWPIiUg4Qo69OIfOq8bV3Xx1pSUEEMkOupqQ1lXe-8w35lhVK9L0XuldPT5vv8d-1sB_ACG14UM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2558836354</pqid></control><display><type>article</type><title>SARS-CoV-2 and Acute Cerebrovascular Events: An Overview</title><source>PubMed Central Open Access</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Ghasemi, Mehdi ; Umeton, Raffaella Pizzolato ; Keyhanian, Kiandokht ; Mohit, Babak ; Rahimian, Nasrin ; Eshaghhosseiny, Niloofarsadaat ; Davoudi, Vahid</creator><creatorcontrib>Ghasemi, Mehdi ; Umeton, Raffaella Pizzolato ; Keyhanian, Kiandokht ; Mohit, Babak ; Rahimian, Nasrin ; Eshaghhosseiny, Niloofarsadaat ; Davoudi, Vahid</creatorcontrib><description>Since the coronavirus disease 2019 (COVID-19) pandemic, due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, accumulating evidence indicates that SARS-CoV-2 infection may be associated with various neurological manifestations, including acute cerebrovascular events (i.e., stroke and cerebral venous thrombosis). These events can occur prior to, during and even after the onset of COVID-19's general symptoms. Although the mechanisms underlying the cerebrovascular complications in patients with COVID-19 are yet to be fully elucidated, the hypercoagulability state, inflammation and altered angiotensin-converting enzyme 2 (ACE-2) signaling in association with SARS-CoV-2 may play key roles. ACE-2 plays a critical role in preserving heart and brain homeostasis. In this review, we discuss the current state of knowledge of the possible mechanisms underlying the acute cerebrovascular events in patients with COVID-19, and we review the current epidemiological studies and case reports of neurovascular complications in association with SARS-CoV-2, as well as the relevant therapeutic approaches that have been considered worldwide. As the number of published COVID-19 cases with cerebrovascular events is growing, prospective studies would help gather more valuable insights into the pathophysiology of cerebrovascular events, effective therapies, and the factors predicting poor functional outcomes related to such events in COVID-19 patients.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm10153349</identifier><identifier>PMID: 34362133</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Clinical medicine ; Coronaviruses ; COVID-19 ; Pandemics ; Review ; Severe acute respiratory syndrome coronavirus 2 ; Stroke ; Viral infections</subject><ispartof>Journal of clinical medicine, 2021-07, Vol.10 (15), p.3349</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-f30540ee8e5820211ebbbe9c44d2f6e660c7f87c11238a789971104de60bee2e3</citedby><cites>FETCH-LOGICAL-c409t-f30540ee8e5820211ebbbe9c44d2f6e660c7f87c11238a789971104de60bee2e3</cites><orcidid>0000-0002-1384-9826 ; 0000-0002-6839-2456 ; 0000-0002-6059-6681</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348889/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348889/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34362133$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ghasemi, Mehdi</creatorcontrib><creatorcontrib>Umeton, Raffaella Pizzolato</creatorcontrib><creatorcontrib>Keyhanian, Kiandokht</creatorcontrib><creatorcontrib>Mohit, Babak</creatorcontrib><creatorcontrib>Rahimian, Nasrin</creatorcontrib><creatorcontrib>Eshaghhosseiny, Niloofarsadaat</creatorcontrib><creatorcontrib>Davoudi, Vahid</creatorcontrib><title>SARS-CoV-2 and Acute Cerebrovascular Events: An Overview</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>Since the coronavirus disease 2019 (COVID-19) pandemic, due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, accumulating evidence indicates that SARS-CoV-2 infection may be associated with various neurological manifestations, including acute cerebrovascular events (i.e., stroke and cerebral venous thrombosis). These events can occur prior to, during and even after the onset of COVID-19's general symptoms. Although the mechanisms underlying the cerebrovascular complications in patients with COVID-19 are yet to be fully elucidated, the hypercoagulability state, inflammation and altered angiotensin-converting enzyme 2 (ACE-2) signaling in association with SARS-CoV-2 may play key roles. ACE-2 plays a critical role in preserving heart and brain homeostasis. In this review, we discuss the current state of knowledge of the possible mechanisms underlying the acute cerebrovascular events in patients with COVID-19, and we review the current epidemiological studies and case reports of neurovascular complications in association with SARS-CoV-2, as well as the relevant therapeutic approaches that have been considered worldwide. As the number of published COVID-19 cases with cerebrovascular events is growing, prospective studies would help gather more valuable insights into the pathophysiology of cerebrovascular events, effective therapies, and the factors predicting poor functional outcomes related to such events in COVID-19 patients.</description><subject>Clinical medicine</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Pandemics</subject><subject>Review</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Stroke</subject><subject>Viral infections</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkc1Lw0AQxRdRrNSevEvAiyDR3Z1NsutBCKV-QKFg1euy2U40JU3qbhPxvzeltVTnMgPz4_Eej5AzRq8BFL2Z2wWjLAIQ6oCccJokIQUJh3t3jwy8n9NupBScJcekBwJizgBOiJymz9NwWL-FPDDVLEhts8JgiA4zV7fG26Y0Lhi1WK38bZBWwaRF1xb4dUqOclN6HGx3n7zej16Gj-F48vA0TMehFVStwhxoJCiixEhyyhnDLMtQWSFmPI8xjqlNcplYxjhIk0ilEsaomGFMM0SO0Cd3G91lky1wZjsjzpR66YqFcd-6NoX--6mKD_1et1qCkFKqTuByK-Dqzwb9Si8Kb7EsTYV14zWPIiUg4Qo69OIfOq8bV3Xx1pSUEEMkOupqQ1lXe-8w35lhVK9L0XuldPT5vv8d-1sB_ACG14UM</recordid><startdate>20210729</startdate><enddate>20210729</enddate><creator>Ghasemi, Mehdi</creator><creator>Umeton, Raffaella Pizzolato</creator><creator>Keyhanian, Kiandokht</creator><creator>Mohit, Babak</creator><creator>Rahimian, Nasrin</creator><creator>Eshaghhosseiny, Niloofarsadaat</creator><creator>Davoudi, Vahid</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1384-9826</orcidid><orcidid>https://orcid.org/0000-0002-6839-2456</orcidid><orcidid>https://orcid.org/0000-0002-6059-6681</orcidid></search><sort><creationdate>20210729</creationdate><title>SARS-CoV-2 and Acute Cerebrovascular Events: An Overview</title><author>Ghasemi, Mehdi ; Umeton, Raffaella Pizzolato ; Keyhanian, Kiandokht ; Mohit, Babak ; Rahimian, Nasrin ; Eshaghhosseiny, Niloofarsadaat ; Davoudi, Vahid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-f30540ee8e5820211ebbbe9c44d2f6e660c7f87c11238a789971104de60bee2e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Clinical medicine</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Pandemics</topic><topic>Review</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Stroke</topic><topic>Viral infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ghasemi, Mehdi</creatorcontrib><creatorcontrib>Umeton, Raffaella Pizzolato</creatorcontrib><creatorcontrib>Keyhanian, Kiandokht</creatorcontrib><creatorcontrib>Mohit, Babak</creatorcontrib><creatorcontrib>Rahimian, Nasrin</creatorcontrib><creatorcontrib>Eshaghhosseiny, Niloofarsadaat</creatorcontrib><creatorcontrib>Davoudi, Vahid</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ghasemi, Mehdi</au><au>Umeton, Raffaella Pizzolato</au><au>Keyhanian, Kiandokht</au><au>Mohit, Babak</au><au>Rahimian, Nasrin</au><au>Eshaghhosseiny, Niloofarsadaat</au><au>Davoudi, Vahid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SARS-CoV-2 and Acute Cerebrovascular Events: An Overview</atitle><jtitle>Journal of clinical medicine</jtitle><addtitle>J Clin Med</addtitle><date>2021-07-29</date><risdate>2021</risdate><volume>10</volume><issue>15</issue><spage>3349</spage><pages>3349-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>Since the coronavirus disease 2019 (COVID-19) pandemic, due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, accumulating evidence indicates that SARS-CoV-2 infection may be associated with various neurological manifestations, including acute cerebrovascular events (i.e., stroke and cerebral venous thrombosis). These events can occur prior to, during and even after the onset of COVID-19's general symptoms. Although the mechanisms underlying the cerebrovascular complications in patients with COVID-19 are yet to be fully elucidated, the hypercoagulability state, inflammation and altered angiotensin-converting enzyme 2 (ACE-2) signaling in association with SARS-CoV-2 may play key roles. ACE-2 plays a critical role in preserving heart and brain homeostasis. In this review, we discuss the current state of knowledge of the possible mechanisms underlying the acute cerebrovascular events in patients with COVID-19, and we review the current epidemiological studies and case reports of neurovascular complications in association with SARS-CoV-2, as well as the relevant therapeutic approaches that have been considered worldwide. As the number of published COVID-19 cases with cerebrovascular events is growing, prospective studies would help gather more valuable insights into the pathophysiology of cerebrovascular events, effective therapies, and the factors predicting poor functional outcomes related to such events in COVID-19 patients.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>34362133</pmid><doi>10.3390/jcm10153349</doi><orcidid>https://orcid.org/0000-0002-1384-9826</orcidid><orcidid>https://orcid.org/0000-0002-6839-2456</orcidid><orcidid>https://orcid.org/0000-0002-6059-6681</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2077-0383 |
| ispartof | Journal of clinical medicine, 2021-07, Vol.10 (15), p.3349 |
| issn | 2077-0383 2077-0383 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8348889 |
| source | PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Clinical medicine Coronaviruses COVID-19 Pandemics Review Severe acute respiratory syndrome coronavirus 2 Stroke Viral infections |
| title | SARS-CoV-2 and Acute Cerebrovascular Events: An Overview |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T01%3A46%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=SARS-CoV-2%20and%20Acute%20Cerebrovascular%20Events:%20An%20Overview&rft.jtitle=Journal%20of%20clinical%20medicine&rft.au=Ghasemi,%20Mehdi&rft.date=2021-07-29&rft.volume=10&rft.issue=15&rft.spage=3349&rft.pages=3349-&rft.issn=2077-0383&rft.eissn=2077-0383&rft_id=info:doi/10.3390/jcm10153349&rft_dat=%3Cproquest_pubme%3E2558836354%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2558836354&rft_id=info:pmid/34362133&rfr_iscdi=true |